{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T07:43:54Z","timestamp":1773474234206,"version":"3.50.1"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several studies have supported the usefulness of the triglycerides and glucose\n                    (TyG) index as a surrogate measure of insulin resistance; however, it has not\n                    been evaluated in insulin secretion. The aim of this study was to assess the\n                    association between the TyG index and insulin secretion in young adults with\n                    normal weight. Apparently healthy non-pregnant women and men, aged 18 to 23\n                    years, were enrolled in a cross-sectional study. Overweight, obesity, pregnancy,\n                    smoking, alcohol consumption, diabetes, liver disease, renal disease,\n                    cardiovascular disease, and neoplasia were the exclusion criteria. Normal weight\n                    was defined by a body mass index\n                        (BMI)\u226518.5&lt;25.0\u2009kg\/m2 and the TyG\n                    index was calculated as the Ln [fasting triglycerides (mg\/dl) x\n                    fasting glucose (mg\/dl)]\/2. A total of 1676 young adults with\n                    normal-weight, 1141 (68%) women, and 535 (32%) men were\n                    enrolled. Of them, 269 (16%) individuals exhibited insulin resistance;\n                    213 (12.7%) women and 56 (3.3%) men. The linear regression\n                    analysis adjusted by gender, BMI, and waist circumference showed a significant\n                    association between the TyG index and HOMA-B (B=\u221235.90;\n                    95% CI:\u221268.25 to\u22123.54, p=0.03) in the overall\n                    population. An additional analysis adjusted by BMI and waist circumference\n                    revealed that the TyG index is significantly associated with HOMA-B in subjects\n                    with and without insulin resistance (B=\u2212104.73; 95%\n                    CI:\u2212204.28 to\u22125.18, p=0.03 and B=\u221274.72;\n                    95% CI:\u2212108.04 to\u221241.40, p&lt;0.001). The results\n                    of this study showed that the TyG index is negatively associated with insulin\n                    secretion in young adults with normal weight.<\/jats:p>","DOI":"10.1055\/a-1713-7821","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T23:30:26Z","timestamp":1641425426000},"page":"33-36","source":"Crossref","is-referenced-by-count":3,"title":["The Triglycerides and Glucose Index is Negatively Associated with\n                    Insulin Secretion in Young Adults with Normal Weight"],"prefix":"10.1055","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3617-4921","authenticated-orcid":false,"given":"Luis E.","family":"Simental-Mend\u00eda","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica, Instituto Mexicano\n                    del Seguro Social, Durango, Dgo., M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"G\u00f3mez-D\u00edaz","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiolog\u00eda\n                    Cl\u00ednica, Centro M\u00e9dico Nacional \"Siglo XXI\",\n                    Instituto Mexicano del Seguro Social, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels H.","family":"Wacher","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n M\u00e9dica en Epidemiolog\u00eda\n                    Cl\u00ednica, Centro M\u00e9dico Nacional \"Siglo XXI\",\n                    Instituto Mexicano del Seguro Social, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9636-9870","authenticated-orcid":false,"given":"Fernando","family":"Guerrero-Romero","sequence":"additional","affiliation":[{"name":"Unidad de Investigaci\u00f3n Biom\u00e9dica, Instituto Mexicano\n                    del Seguro Social, Durango, Dgo., M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,1,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/0140-6736(92)92814-V","article-title":"Role of glucose and insulin resistance in development of type 2 diabetes\n                    mellitus: results of a 25-year follow-up study","volume":"340","author":"B C Martin","year":"1992","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1007\/s00125-017-4275-6","article-title":"Trajectories of glycaemia, insulin sensitivity and insulin secretion in South\n                    Asian and white individuals before diagnosis of type 2 diabetes: a longitudinal\n                    analysis from the Whitehall II cohort study","volume":"60","author":"A Hulman","year":"2017","journal-title":"Diabetologia"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s12272-019-01138-9","article-title":"Hypothalamic inflammation and obesity: a mechanistic review","volume":"42","author":"J Seong","year":"2019","journal-title":"Arch Pharm Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"117863881983171","DOI":"10.1177\/1178638819831712","article-title":"The value of anthropometric measures in nutrition and metabolism: comment on\n                    anthropometrically predicted visceral adipose tissue and blood-based biomarkers:\n                    a cross-sectional analysis","volume":"12","author":"J C Brown","year":"2019","journal-title":"Nutr Metab Insights"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.2337\/diab.42.11.1663","article-title":"Quantification of the relationship between insulin sensitivity and beta-cell\n                    function in human subjects. Evidence for a hyperbolic function","volume":"42","author":"S E Kahn","year":"1993","journal-title":"Diabetes"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"3611","DOI":"10.2147\/DMSO.S275898","article-title":"Obesity, insulin resistance, and type 2 diabetes: Associations and therapeutic\n                    implications","volume":"13","author":"Y T Wondmkun","year":"2020","journal-title":"Diabetes Metab Syndr Obes Targets Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.dsx.2019.02.023","article-title":"Insulin resistance is a cardiovascular risk factor in humans","volume":"13","author":"M M Adeva-Andany","year":"2019","journal-title":"Diabetes Metab Syndr Clin Res Rev"},{"key":"ref8","first-page":"106","article-title":"Diagnosis and treatment of polycystic ovary syndrome","volume":"94","author":"T Williams","year":"2016","journal-title":"Am Fam Physician"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.beem.2016.06.006","article-title":"Non-alcoholic fatty liver disease and risk of type 2 diabetes","volume":"30","author":"S Lallukka","year":"2016","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"ref10","first-page":"E214","article-title":"Glucose clamp technique: A method for quantifying insulin secretion and\n                    resistance","volume":"6","author":"R A DeFronzo","year":"1979","journal-title":"Am J Physiol Endocrinol Metab Gastrointest Physiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1210\/jc.2010-0288","article-title":"The product of triglycerides and glucose, a simple measure of insulin\n                    sensitivity. Comparison with the euglycemic-hyperinsulinemic clamp","volume":"95","author":"F Guerrero-Romero","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1089\/met.2008.0034","article-title":"The product of fasting glucose and triglycerides as surrogate for identifying\n                    insulin resistance in apparently healthy subjects","volume":"6","author":"L E Simental-Mend\u00eda","year":"2008","journal-title":"Metab Syndr Relat Disord"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.arcmed.2016.08.012","article-title":"Fasting triglycerides and glucose index as a diagnostic test for insulin\n                    resistance in young adults","volume":"47","author":"F Guerrero-Romero","year":"2016","journal-title":"Arch Med Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/pedi.12303","article-title":"Triglyceride glucose index as a surrogate measure of insulin sensitivity in\n                    obese adolescents with normoglycemia, prediabetes, and type 2 diabetes mellitus:\n                    comparison with the hyperinsulinemic\u2013euglycemic clamp","volume":"17","author":"N S Mohd Nor","year":"2016","journal-title":"Pediatr Diabetes"},{"key":"ref15","first-page":"32","article-title":"Triglyceride\/glucose index is a reliable alternative marker for insulin\n                    resistance in South American overweight and obese children and adolescents","author":"J C Locateli","year":"2019","journal-title":"J Pediatr Endocrinol Metab"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.galenos.2019.2019.0024","article-title":"Triglyceride glucose index as a surrogate measure of insulin sensitivity in a\n                    Caucasian pediatric population","author":"V Calcaterra","year":"2020","journal-title":"J Clin Res Pediatr Endocrinol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/ijo.2017.14","article-title":"Triglycerides\/glucose index is a useful surrogate marker of insulin\n                    resistance among adolescents","volume":"41","author":"B Kang","year":"2017","journal-title":"Int J Obes"},{"key":"ref18","first-page":"894","article-title":"Report of a WHO consultation","author":"Anon: Obesity: preventing and managing the global\n                    epidemic","year":"2000","journal-title":"WHO Tech Rep Ser"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and \u03b2-cell function\n                    from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"D R Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.2337\/diabetes.48.9.1779","article-title":"Comparison of tests of b-cell function across a range of glucose tolerance from\n                    normal to diabetes","volume":"48","author":"M P Hermans","year":"1999","journal-title":"Diabetes"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s40519-018-0481-6","article-title":"Insulin resistance in obesity: an overview of fundamental alterations","volume":"23","author":"R Barazzoni","year":"2018","journal-title":"Eat Weight Disord"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.metabol.2003.10.032","article-title":"Prevalence of insulin resistance and associated cardiovascular disease risk\n                    factors among normal weight, overweight, and obese individuals","volume":"53","author":"T McLaughlin","year":"2004","journal-title":"Metabolism"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2337\/dc08-1195","article-title":"Natural history of insulin sensitivity and insulin secretion in the progression\n                    from normal glucose tolerance to impaired fasting glycemia and impaired glucose\n                    tolerance: the inter99 study","volume":"32","author":"K K\u00e6rch","year":"2009","journal-title":"Diabetes Care"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0188-0128(98)00008-6","article-title":"Changes in insulin sensitivity, secretion and glucose effectiveness during\n                    menstrual cycle","volume":"30","author":"JM E Pulido","year":"1999","journal-title":"Arch Med Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1046\/j.1464-5491.2003.01059.x","article-title":"Gender differences in the prevalence of impaired fasting glycaemia and impaired\n                    glucose tolerance in Mauritius. Does sex matter?","volume":"20","author":"J W Williams","year":"2003","journal-title":"Diabet Med"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1713-7821.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T23:31:42Z","timestamp":1641425502000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1713-7821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":25,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2022,1,5]]},"published-print":{"date-parts":[[2022,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1713-7821","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"value":"0018-5043","type":"print"},{"value":"1439-4286","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]}}}