{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T20:28:57Z","timestamp":1791232137619,"version":"4.1.0"},"reference-count":90,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Sports Med"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Exercise-based cardiac rehabilitation may be an effective non-pharmacological\n                    intervention for improving endothelial function in coronary artery disease\n                    patients. Therefore, this systematic review with meta-analysis aimed to (a)\n                    estimate the training-induced effect on endothelial and vascular smooth muscle\n                    function, assessed by flow-mediated dilation and nitroglycerin-mediated\n                    dilation, respectively, in coronary artery disease patients; and to (b) study\n                    the influence of potential trial-level variables (i.\u2009e. study and\n                    intervention characteristics) on the training-induced effect on endothelial and\n                    vascular smooth muscle function. Electronic searches were performed in Pubmed,\n                    Scopus, and Embase up to February 2021. Random-effects models of standardised\n                    mean change were estimated. Heterogeneity analyses were performed by using the\n                        Chi\n          \n            2\n           test and I\n          \n            2\n           index.\n                    Our results showed that exercise-based cardiac rehabilitation significantly\n                    enhanced flow-mediated dilation (1.04 [95% confidence\n                    interval=0.76 to 1.31]) but did not significantly change\n                    nitroglycerin-mediated dilation (0.05 [95% confidence\n                    interval=\u20130.03 to 0.13]). Heterogeneity testing reached\n                    statistical significance (p&lt;.001) with high inconsistency for\n                    flow-mediated dilation (I\n          \n            2\n          \n          =92%).\n                    Nevertheless, none of the analysed variables influenced the training-induced\n                    effect on flow-mediated dilation. Exercise-based cardiac rehabilitation seems to\n                    be an effective therapeutic strategy for improving endothelial-dependent\n                    dilation in coronary artery disease patients, which may aid in the prevention of\n                    cardiovascular events.<\/jats:p>","DOI":"10.1055\/a-1717-1798","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T23:23:25Z","timestamp":1650929005000},"page":"905-920","source":"Crossref","is-referenced-by-count":17,"title":["Cardiac Rehabilitation Improves Endothelial Function in Coronary\n                    Artery Disease Patients"],"prefix":"10.1055","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1399-2411","authenticated-orcid":false,"given":"Agust\u00edn","family":"Manresa-Rocamora","sequence":"additional","affiliation":[{"name":"Sports Research Centre, Department of Sport Sciences, Miguel\n                    Hern\u00e1ndez University of Elche, 03202 Elche, Spain"},{"name":"Institute for Health and Biomedical Research (ISABIAL Foundation),\n                    Miguel Hernandez University, 03550 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9094-1493","authenticated-orcid":false,"given":"Fernando","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"School of Health Sciences and Institute of Biomedicine- iBiMED,\n                    Universidade de Aveiro, Aveiro, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Casanova-Liz\u00f3n","sequence":"additional","affiliation":[{"name":"Sports Research Centre, Department of Sport Sciences, Miguel\n                    Hern\u00e1ndez University of Elche, 03202 Elche, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2998-8537","authenticated-orcid":false,"given":"Andrew A.","family":"Flatt","sequence":"additional","affiliation":[{"name":"Health Sciences and Kinesiology, Georgia Southern University \u2013\n                    Armstrong Campus, Savannah, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1917-6634","authenticated-orcid":false,"given":"Jos\u00e9 Manuel","family":"Sarabia","sequence":"additional","affiliation":[{"name":"Sports Research Centre, Department of Sport Sciences, Miguel\n                    Hern\u00e1ndez University of Elche, 03202 Elche, Spain"},{"name":"Institute for Health and Biomedical Research (ISABIAL Foundation),\n                    Miguel Hernandez University, 03550 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2291-5899","authenticated-orcid":false,"given":"Manuel","family":"Moya-Ram\u00f3n","sequence":"additional","affiliation":[{"name":"Sports Research Centre, Department of Sport Sciences, Miguel\n                    Hern\u00e1ndez University of Elche, 03202 Elche, Spain"},{"name":"Institute for Health and Biomedical Research (ISABIAL Foundation),\n                    Miguel Hernandez University, 03550 Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1016\/0735-1097(94)90627-0","article-title":"Evidence that selective endothelial dysfunction may occur in the absence of\n                    angiographic or ultrasound atherosclerosis in patients with risk factors for\n                    atherosclerosis","volume":"23","author":"K G Reddy","year":"1994","journal-title":"J Am Coll Cardiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1161\/01.CIR.0000153349.77489.CF","article-title":"Vascular endothelial dysfunction and mortality risk in patients with chronic\n                    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