{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T09:47:12Z","timestamp":1788515232093,"version":"build-2803163510"},"reference-count":35,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective Exercise-induced bronchoconstriction (EIB) occurs frequently in\n                    children and adolescents and may be a sign of insufficient asthma control. EIB\n                    is often evaluated by respiratory symptoms, spirometry, eNO measurement and\n                    methacholine testing (MCT) instead of time consuming exercise test. Aim of this\n                    study was to analyse the amount of patients for which an exercise challenge in a\n                    cold chamber (ECC) was needed for a clear EIB diagnosis, to characterize EIB\n                    phenotypes and the incidence of exercise induced laryngeal obstruction (EILO) in\n                    a large cohort of patients with EIB.<\/jats:p>\n                  <jats:p>Methods A retrospective analysis was performed in 595 children and\n                    adolescents (mean age 12.1 years) with suspected EIB from January 2014 to\n                    December 2018. Complete data sets of skin prick test, spirometry, eNO and MCT\n                    were available from 336 patients.<\/jats:p>\n                  <jats:p>Results An ECC to confirm the EIB diagnosis was performed in 125\n                    (37.2%) of patients. Three EIB phenotypes were detected: group 1: EIB\n                    without allergic sensitization (n=159); group 2: EIB with other than\n                    house dust mite (HDM) sensitization (n=87) and group 3: EIB with HDM\n                    sensitization (n=90). MCT and eNO showed significant differences between\n                    the subgroups: An eNO&gt;46 ppb and\/or a MCT&lt;0.1\u2009mg\n                    was found in 23.9% vs. 50.6% vs. 57.8% in group\n                    1\u20133, respectively. Significantly more patients suffered from EILO in\n                    group 1 compared to group 2 and 3 (n=13 vs. n=1).<\/jats:p>\n                  <jats:p>Conclusion EIB without sensitization is as often as EIB with\n                    sensitization. In patients without sensitization, EILO has to be considered as a\n                    possible cause of symptoms during exercise.<\/jats:p>","DOI":"10.1055\/a-1717-2178","type":"journal-article","created":{"date-parts":[[2022,2,3]],"date-time":"2022-02-03T18:51:45Z","timestamp":1643914305000},"page":"267-276","source":"Crossref","is-referenced-by-count":1,"title":["Evaluating Children and Adolescents with Suspected Exercise Induced\n                    Asthma: Real Life Data"],"prefix":"10.1055","volume":"234","author":[{"given":"Melanie","family":"Dre\u00dfler","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonology and Cystic fibrosis, Department for\n                    Children and Adolescents, University Hospital Frankfurt, Goethe-University,\n                    Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena","family":"Donath","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonology and Cystic fibrosis, Department for\n                    Children and Adolescents, University Hospital Frankfurt, Goethe-University,\n                    Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thao Uyen","family":"Quang","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonology and Cystic fibrosis, Department for\n                    Children and Adolescents, University Hospital Frankfurt, Goethe-University,\n                    Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hutter","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonology and Cystic fibrosis, Department for\n                    Children and Adolescents, University Hospital Frankfurt, Goethe-University,\n                    Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordis","family":"Trischler","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonology and Cystic fibrosis, Department for\n                    Children and Adolescents, University Hospital Frankfurt, Goethe-University,\n                    Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Zielen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonology and Cystic fibrosis, Department for\n                    Children and Adolescents, University Hospital Frankfurt, Goethe-University,\n                    Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schulze","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonology and Cystic fibrosis, Department for\n                    Children and Adolescents, University Hospital Frankfurt, Goethe-University,\n                    Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Bl\u00fcmchen","sequence":"additional","affiliation":[{"name":"Division of Allergy, Pulmonology and Cystic fibrosis, Department for\n                    Children and Adolescents, University Hospital Frankfurt, Goethe-University,\n                    Frankfurt, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,2,3]]},"reference":[{"key":"ref1","first-page":"120","article-title":"Reproducibility of the airway response to an exercise protocol standardized for\n                    intensity, duration, and inspired air conditions, in subjects with symptoms\n                    suggestive of asthma","volume":"11(1)","author":"S D Anderson","journal-title":"Respir Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1056\/NEJMra1407552","article-title":"Asthma and exercise-induced bronchoconstriction in athletes","volume":"372","author":"L Boulet","year":"2015","journal-title":"N Engl J Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.jaci.2010.02.002","article-title":"Physical activity in young children is reduced with increasing bronchial\n                    responsiveness","volume":"125","author":"M Brasholt","year":"2010","journal-title":"J Allergy Clin Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1964","DOI":"10.1378\/chest.128.4.1964","article-title":"Exhaled nitric oxide predicts exercise-induced bronchoconstriction in asthmatic\n                    school children","volume":"128","author":"F Buchvald","year":"2005","journal-title":"Chest"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/ppul.23530","article-title":"Exercise-induced inspiratory symptoms in school children","volume":"51","author":"F Buchvald","year":"2016","journal-title":"Pediatr Pulmonol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/S0954-6111(98)90114-7","article-title":"Cold air inhalation and exercise-induced bronchoconstriction in relationship to\n                    metacholine bronchial responsiveness: different patterns in asthmatic children\n                    and children with other chronic lung diseases","volume":"92","author":"K H Carlsen","year":"1998","journal-title":"Respir Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1007\/s00405-011-1612-0","article-title":"Exercise-induced laryngeal obstructions: prevalence and symptoms in the general\n                    public","volume":"268","author":"P M Christensen","year":"2011","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1601526","DOI":"10.1183\/13993003.01526-2016","article-title":"ERS technical standard on bronchial challenge testing: general considerations\n                    and performance of methacholine challenge tests","volume":"49","author":"A L Coates","year":"2017","journal-title":"Eur Respir J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1186\/s12944-020-01343-2","article-title":"Oil supplementation with a special combination of n-3 and n-6 long-chain\n                    polyunsaturated fatty acids does not protect for exercise induced asthma: a\n                    double-blind placebo-controlled trial","volume":"19(1)","author":"M Dre\u00dfler","year":"2020","journal-title":"Lipids Health Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.niox.2018.03.004","article-title":"Exhaled NO as a predictor of exercise-induced asthma in cold air","volume":"76","author":"M Dre\u00dfler","year":"2018","journal-title":"Nitric Oxide"},{"key":"ref11","first-page":"94","article-title":"Predictors and reproducibility of exercise-induced bronchoconstriction in cold\n                    air","volume":"19(1)","author":"M Dre\u00dfler","journal-title":"BMC Pulm Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1378\/chest.124.2.639","article-title":"Exhaled nitric oxide as a predictor of exercise-induced bronchoconstriction","volume":"124","author":"S M ElHalawani","year":"2003","journal-title":"Chest"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.niox.2012.05.002","article-title":"Fractional exhaled nitric oxide (FeNO) may predict exercise-induced\n                    bronchoconstriction (EIB) in schoolchildren with atopic asthma","volume":"27","author":"T Grzelewski","year":"2012","journal-title":"Nitric Oxide"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1801033","DOI":"10.1183\/13993003.01033-2018","article-title":"ERS technical standard on bronchial challenge testing: pathophysiology and\n                    methodology of indirect airway challenge testing","volume":"52","author":"T S Hallstrand","year":"2018","journal-title":"Eur Respir J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/01.mlg.0000184528.16229.ba","article-title":"Halvorsen Tet al. Continuous laryngoscopy exercise test: A method for\n                    visualizing laryngeal dysfunction during exercise","volume":"116","author":"J-H Heimdal","year":"2006","journal-title":"Laryngoscope"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1016\/j.jaip.2020.01.057","article-title":"Exercise-associated dyspnea and stridor: Thinking beyond asthma","volume":"8","author":"J H Hull","year":"2020","journal-title":"J Allergy Clin Immunol Pract"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/thoraxjnl-2014-205738","article-title":"Prevalence of exercise-induced bronchoconstriction and exercise-induced\n                    laryngeal obstruction in a general adolescent population","volume":"70","author":"H Johansson","year":"2015","journal-title":"Thorax"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1398-9995.2005.00938.x","article-title":"Asthma in every fifth child in Oslo, Norway: a 10-year follow up of a birth\n                    cohort study","volume":"61","author":"K C L\u00f8drup Carlsen","year":"2006","journal-title":"Allergy"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/s00405-011-1656-1","article-title":"Exercise-induced laryngeal obstruction: natural history and effect of surgical\n                    treatment","volume":"268","author":"R C Maat","year":"2011","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1007\/s00405-009-1030-8","article-title":"Audiovisual assessment of exercise-induced laryngeal obstruction: Reliability\n                    and validity of observations","volume":"266","author":"R C Maat","year":"2009","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.1249\/MSS.0b013e318298b19a","article-title":"High Prevalence of Exercise-Induced Laryngeal Obstruction in Athletes","volume":"45","author":"E W Nielsen","year":"2013","journal-title":"Med Sci Sports Exerc"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1164\/rccm.201303-0437ST","article-title":"An official American Thoracic Society clinical practice guideline:\n                    exercise-induced bronchoconstriction","volume":"187","author":"J P Parsons","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1249\/mss.0b013e3180986e45","article-title":"Prevalence of exercise-induced bronchospasm in a cohort of varsity college\n                    athletes","volume":"39","author":"J P Parsons","year":"2007","journal-title":"Medicine & Science in Sports &\n                    Exercise"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1164\/rccm.200811-1756PR","article-title":"Pro: The evidence for a causal role of dust mites in asthma","volume":"180","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1183\/09031936.00080312","article-title":"Multi-ethnic reference values for spirometry for the 3\u201395-yr age range:\n                    the global lung function 2012 equations","volume":"40","author":"P H Quanjer","year":"2012","journal-title":"Eur Respir J"},{"key":"ref26","first-page":"86","article-title":"Exercise inducible laryngeal obstruction: Diagnostics and management","volume":"21","author":"O D R\u00f8ksund","year":"2017","journal-title":"Paediatr Respir Rev"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1111\/j.1398-9995.2005.00901.x","article-title":"Exhaled nitric oxide and exercise-induced bronchoconstriction in young male\n                    conscripts: association only in atopics","volume":"60","author":"A Rouhos","year":"2005","journal-title":"Allergy"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jaci.2008.06.014","article-title":"Exercise and other indirect challenges to demonstrate asthma or exercise-induced\n                    bronchoconstriction in athletes","volume":"122","author":"K W Rundell","year":"2008","journal-title":"J Allergy Clin Immunol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1016\/j.rmed.2009.06.007","article-title":"Methacholine challenge-comparison of an ATS protocol to a new rapid single\n                    concentration technique","volume":"103","author":"J Schulze","year":"2009","journal-title":"Respir Med"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.rmed.2019.01.011","article-title":"Correlation of spirometry and body plethysmography during exercise-induced\n                    bronchial obstruction","volume":"148","author":"J Schulze","year":"2019","journal-title":"Respir Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1056\/NEJMoa022363","article-title":"A longitudinal, population-based, cohort study of childhood asthma followed to\n                    adulthood","volume":"349","author":"M R Sears","year":"2003","journal-title":"N Engl J Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1136\/adc.2004.063974","article-title":"How accurate is the diagnosis of exercise induced asthma among Vancouver\n                    schoolchildren?","volume":"90","author":"M Seear","year":"2005","journal-title":"Arch Dis Child"},{"key":"ref33","first-page":"E400","article-title":"Exercise-induced laryngeal obstruction (EILO) in children and young adults: From\n                    referral to diagnosis","volume":"130","author":"E O Shay","year":"2020","journal-title":"Laryngoscope."},{"key":"ref34","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.jaip.2013.11.001","article-title":"Improving screening and diagnosis of exercise-induced bronchoconstriction: a\n                    call to action","volume":"2","author":"J M Weiler","year":"2014","journal-title":"J Allergy Clin Immunol Pract"},{"key":"ref35","first-page":"879","article-title":"Severity of exercise-induced bronchoconstriction is related to airway\n                    eosinophilic inflammation in patients with asthma","volume":"12","author":"T Yoshikawa","year":"1998","journal-title":"ERS"}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1717-2178.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T20:30:54Z","timestamp":1764102654000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1717-2178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,3]]},"references-count":35,"journal-issue":{"issue":"05","published-online":{"date-parts":[[2022,9,21]]},"published-print":{"date-parts":[[2022,9]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1717-2178","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"value":"0300-8630","type":"print"},{"value":"1439-3824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,3]]}}}