{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:28:41Z","timestamp":1787318921078,"version":"build-2736575974"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"01","license":[{"start":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T00:00:00Z","timestamp":1639353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Nihon Kohden"},{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000801","name":"Bayer HealthCare","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000801","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004948","name":"Astellas Pharma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100004948","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005612","name":"Shionogi","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005612","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100010793","name":"Pfizer Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100010793","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100009015","name":"Abbott Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009015","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100010486","name":"Teijin Pharma","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100010486","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["TH Open"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective\u2003Although blood thrombogenicity seems to be one of the determinant factors for the development of acute myocardial infarction (MI), it has not been dealt with in-depth. This study aimed to investigate blood thrombogenicity and its change in acute MI patients.<\/jats:p>\n                  <jats:p>Methods and Results\u2003We designed a prospective, observational study that included 51 acute MI patients and 83 stable coronary artery disease (CAD) patients who underwent cardiac catheterization, comparing thrombogenicity of the whole blood between: (1) acute MI patients and stable CAD patients; and (2) acute and chronic phase in MI patients. Blood thrombogenicity was evaluated by the Total Thrombus-Formation Analysis System (T-TAS) using the area under the flow pressure curve (AUC30) for the AR-chip. Acute MI patients had significantly higher AUC30 than stable CAD patients (median [interquartile range], 1,771 [1,585\u20131,884] vs. 1,677 [1,527\u20131,756], p\u2009=\u20090.010). Multivariate regression analysis identified acute MI with initial TIMI flow grade 0\/1 as an independent determinant of high AUC30 (\u03b2\u2009=\u20090.211, p\u2009=\u20090.013). In acute MI patients, AUC30 decreased significantly from acute to chronic phase (1,859 [1,550\u20132,008] to 1,521 [1,328\u20131,745], p\u2009=\u20090.001).<\/jats:p>\n                  <jats:p>Conclusion\u2003Blood thrombogenicity was significantly higher in acute MI patients than in stable CAD patients. Acute MI with initial TIMI flow grade 0\/1 was significantly associated with high blood thrombogenicity by multivariate analysis. In acute MI patients, blood thrombogenicity was temporarily higher in acute phase than in chronic phase.<\/jats:p>","DOI":"10.1055\/a-1719-6178","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T19:31:17Z","timestamp":1639423877000},"page":"e26-e32","source":"Crossref","is-referenced-by-count":2,"title":["Temporary Rise in Blood Thrombogenicity in Patients with Acute Myocardial Infarction"],"prefix":"10.1055","volume":"06","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0274-5052","authenticated-orcid":false,"given":"Shumpei","family":"Kosugi","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0514-106X","authenticated-orcid":false,"given":"Yasunori","family":"Ueda","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Abe","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuniyasu","family":"Ikeoka","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Mishima","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuhisa","family":"Ozaki","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohtaro","family":"Takayasu","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Ohashi","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruya","family":"Yamane","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Horiuchi","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Iehara","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Osaki","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuki","family":"Ozato","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Inoue","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Koretsune","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, National Hospital Organization Osaka National Hospital, Osaka, 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Open"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1719-6178.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T04:16:57Z","timestamp":1676002617000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1719-6178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,13]]},"references-count":30,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2022,1,17]]},"published-print":{"date-parts":[[2022,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1719-6178","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["2512-9465"],"issn-type":[{"value":"2512-9465","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12,13]]},"published":{"date-parts":[[2021,12,13]]}}}