{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,3,30]],"date-time":"2022-03-30T13:19:15Z","timestamp":1648646355455},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund Darstellung der klinischen Befunde der ableitenden Tr\u00e4nenwege\n\t\t\t\t\tbei Patienten mit kongenitalem klinischen Anophthalmus und funktionslosem\n\t\t\t\t\tMikrophthalmus (MAC-Komplex).<\/jats:p><jats:p>\n          Methoden Retrospektive Studie von 207 konsekutiven Patienten, die zwischen\n\t\t\t\t\t1998 und 2021 mindestens einmal mit hochhydrophilen selbstquellenden Expandern\n\t\t\t\t\tbei MAC operiert wurden. Das Tr\u00e4nenwegssystem wurde in Vollnarkose immer vor\n\t\t\t\t\tallen anderen operativen Ma\u00dfnahmen sondiert und gesp\u00fclt.<\/jats:p><jats:p>\n          Ergebnisse 64 Patienten wurden wegen m\u00f6glicher Fehldiagnosen aufgrund\n\t\t\t\t\tvorheriger Lid- oder Orbitachirurgie an anderer Stelle oder wegen fehlender\n\t\t\t\t\tDaten ausgeschlossen. Die Analyse umfasste daher 67 M\u00e4dchen und 76 Jungen im\n\t\t\t\t\tAlter zwischen 1 und 126 Monaten (medianes Alter: 5 Monate). 72\u00a0Patienten wiesen\n\t\t\t\t\teinen unilateralen und 42 einen bilateralen Anophthalmus auf, 24 einen\n\t\t\t\t\tunilateralen und 5 einen bilateralen Mikrophthalmus; somit standen 286\n\t\t\t\t\tAugenh\u00f6hlen (davon 190 mit Pathologie) zur Beurteilung zur Verf\u00fcgung. Bei\n\t\t\t\t\teinseitigen F\u00e4llen war das Tr\u00e4nenwegssystem auf der normalen Seite nie\n\t\t\t\t\tbetroffen. Auf der anophthalmischen oder mikrophthalmischen Seite war das\n\t\t\t\t\tTr\u00e4nenwegssystem nur in 68 Augenh\u00f6hlen (35,8%) unauff\u00e4llig. Der h\u00e4ufigste Befund\n\t\t\t\t\twar eine Kanalikulusstenose (91 Augenh\u00f6hlen; 48%). Eine Stenose des Canaliculus\n\t\t\t\t\tcommunis wurde in 12 Augenh\u00f6hlen (6,3%) und eine Obstruktion des Ductus\n\t\t\t\t\tnasolacrimalis in 9\u00a0Augenh\u00f6hlen (4,7%) festgestellt. Es gab 4 F\u00e4lle von Aplasie\n\t\t\t\t\tbeider Tr\u00e4nenp\u00fcnktchen, andere Anomalien waren nicht auff\u00e4llig. Beim einseitigen\n\t\t\t\t\tAnophthalmus lie\u00df sich bei pathologischen Befunden der Tr\u00e4nenwegssondierung ein\n\t\t\t\t\tsignifikanter Zusammenhang mit einer Lippen-Kiefer-Gaumen-Spalte feststellen,\n\t\t\t\t\twas in den 3 anderen Gruppen nicht der Fall war.<\/jats:p><jats:p>\n          Schlussfolgerungen Beim kongenitalen klinischen Anophthalmus ist das\n\t\t\t\t\tTr\u00e4nensystem in bis zu 66,5% der F\u00e4lle betroffen, meist aufgrund einer\n\t\t\t\t\tKanalikulusstenose. Auch wenn es keine eindeutigen Hinweise auf einen\n\t\t\t\t\tembryologischen Zusammenhang gibt, ist diese Assoziation sicher kein\n\t\t\t\t\tZufallsbefund.<\/jats:p>","DOI":"10.1055\/a-1721-2375","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T23:46:24Z","timestamp":1644018384000},"page":"57-63","source":"Crossref","is-referenced-by-count":0,"title":["Tr\u00e4nenwegsbefunde von 143 Kindern mit\n\t\t\t\t\tMikrophthalmus-Anophthalmus-Komplex"],"prefix":"10.1055","volume":"239","author":[{"given":"Michael P.","family":"Schittkowski","sequence":"additional","affiliation":[{"name":"Abteilung Augenheilkunde, Bereich Strabologie, Neuroophthalmologie und\n\t\t\t\t\tokuloplastische Chirurgie, Universit\u00e4tsmedizin G\u00f6ttingen,\n\t\t\t\t\tDeutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Leha","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Medizinische Statistik, Georg-August-Universit\u00e4t\n\t\t\t\t\tG\u00f6ttingen, Universit\u00e4tsmedizin G\u00f6ttingen, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maren","family":"Horn","sequence":"additional","affiliation":[{"name":"Abteilung Augenheilkunde, Bereich Strabologie, Neuroophthalmologie und\n\t\t\t\t\tokuloplastische Chirurgie, Universit\u00e4tsmedizin G\u00f6ttingen,\n\t\t\t\t\tDeutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Naxer","sequence":"additional","affiliation":[{"name":"Abteilung Augenheilkunde, Bereich Strabologie, Neuroophthalmologie und\n\t\t\t\t\tokuloplastische Chirurgie, Universit\u00e4tsmedizin G\u00f6ttingen,\n\t\t\t\t\tDeutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1478","DOI":"10.1002\/bdr2.1413","article-title":"Population-based birth defects 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