{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:31:57Z","timestamp":1767652317274},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction Maternally derived antibodies are a key element of neonatal immunity. So far, limited data has shown transplacental transmission of antibodies after coronavirus disease\n\t\t\t\t\t2019 (COVID-19) vaccination with BNT162b2 in the third trimester. Our aim was to detect vertically transferred immunity after COVID-19 vaccination with BNT162b2 (Comirnaty, BioNTech-Pfizer)\n\t\t\t\t\tor mRNA-1273 (Spikevax, Moderna) in the first, second or third trimester of pregnancy, and investigate the impact of maternal characteristics on umbilical cord antibody titre in newborns\n\t\t\t\t\tafter delivery.<\/jats:p><jats:p>\n          Study Design Women who gave birth in our department and were vaccinated against COVID-19 during pregnancy were enrolled in CRONOS Satellite, a subproject of the German\n\t\t\t\t\tCOVID-19-Related Obstetric and Neonatal Outcome Study. The titre of immunoglobulin G (IgG) antibodies to the receptor-binding domain of the SARS-CoV-2 spike protein was quantified in\n\t\t\t\t\tumbilical cord blood using the SARS-CoV-2 IgG\u00a0II Quant immunoassay. Correlations between antibody titre and variables, including week of pregnancy when vaccinated, interval between\n\t\t\t\t\tvaccination and delivery, age and body mass index (BMI) were assessed with Spearman\u02bcs rank correlation. A follow-up was conducted by phone interview 4\u200a\u2013\u200a6 weeks after delivery.<\/jats:p><jats:p>\n          Results The study cohort consisted of 70 women and their 74\u00a0newborns. Vaccine-generated antibodies were present in all samples, irrespective of the vaccination type or time of\n\t\t\t\t\tvaccination. None of the parameters of interest showed a meaningful correlation with cord blood antibody concentrations (rho values &lt;\u20090.5). No adverse outcomes (including foetal\n\t\t\t\t\tmalformation) were reported, even after vaccination in the first trimester.<\/jats:p><jats:p>\n          Conclusions Transplacental passage of SARS-CoV-2 antibodies from mother to child was demonstrated in all cases in the present study. It can therefore be assumed that the newborns of\n\t\t\t\t\tmothers vaccinated at any time during pregnancy receive antibodies via the placenta which potentially provide them with protection against COVID-19. This is an additional argument when\n\t\t\t\t\tcounselling pregnant women about vaccination in pregnancy.<\/jats:p>","DOI":"10.1055\/a-1721-4908","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T22:48:04Z","timestamp":1651877284000},"page":"510-516","source":"Crossref","is-referenced-by-count":10,"title":["Assessment of Neonatal Cord Blood SARS-CoV-2 Antibodies after COVID-19 Vaccination in Pregnancy: A Prospective Cohort Study"],"prefix":"10.1055","volume":"82","author":[{"given":"Marina","family":"Sourouni","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janina","family":"Braun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Oelmeier","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mareike","family":"M\u00f6llers","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Willy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc T.","family":"Hennies","sequence":"additional","affiliation":[{"name":"Department of clinical Virology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen Ann","family":"K\u00f6ster","sequence":"additional","affiliation":[{"name":"Gynaecological Practice, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Pecks","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital Schleswig-Holstein, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter","family":"Klockenbusch","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ralf","family":"Schmitz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University Hospital M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"ref2","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.3389\/fimmu.2020.01672","article-title":"Pregnancy, viral infection, and COVID-19","volume":"11","author":"R W Alberca","year":"2020","journal-title":"Front Immunol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"769","DOI":"10.15585\/mmwr.mm6925a1","article-title":"Characteristics of symptomatic women of reproductive age with laboratory-confirmed SARS-CoV-2 infection by pregnancy status \u2013 United States, January 22","volume":"69","author":"L D Zambrano","year":"2020","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1055\/a-1684-3156","article-title":"Booster-Impfung mit mRNA-Impfstoffen gegen das SARS-CoV-2-Virus","volume":"82","author":"U Pecks","year":"2022","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"594","DOI":"10.1001\/jamapediatrics.2021.0038","article-title":"Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios","volume":"175","author":"D D Flannery","year":"2021","journal-title":"JAMA Pediatr"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/AOG.0000000000004199","article-title":"Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies at Delivery in Women, Partners, and Newborns","volume":"137","author":"P Egerup","year":"2021","journal-title":"Obstet Gynecol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"2621","DOI":"10.1038\/s41372-021-01216-1","article-title":"Titers of SARS CoV-2 antibodies in cord blood of neonates whose mothers contracted SARS CoV-2 (COVID-19) during pregnancy and in those whose mothers were vaccinated with mRNA to SARS CoV-2\n\t\t\t\t\tduring pregnancy","volume":"41","author":"L Kashani-Ligumsky","year":"2021","journal-title":"J Perinatol"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1055\/a-1768-0415","article-title":"Antibody Response and Maternofetal Antibody Transfer in SARS-CoV-2-Positive Pregnant Women: A Multicenter Observational Study","volume":"82","author":"S Enengl","year":"2022","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1097\/AOG.0000000000004367","article-title":"Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibodies in Neonatal Cord Blood After Vaccination in Pregnancy","volume":"137","author":"L Gill","year":"2021","journal-title":"Obstet Gynecol"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"3484","DOI":"10.1080\/21645515.2021.1947099","article-title":"Cord blood antibody following maternal SARS-CoV-2 inactive vaccine (CoronaVac) administration during the 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