{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T17:18:39Z","timestamp":1788023919567,"version":"build-2784847793"},"reference-count":41,"publisher":"Georg Thieme Verlag KG","issue":"14","funder":[{"name":"Establishment project of Jiangxi science and technology\n\t\t\t\t\t\tinnovation platform","award":["20212BCD42009"],"award-info":[{"award-number":["20212BCD42009"]}]},{"name":"Science and technology project of Jiangxi Administration of\n\t\t\t\t\t\ttraditional Chinese Medicine","award":["2020Z003"],"award-info":[{"award-number":["2020Z003"]}]},{"name":"Science and technology project of Jiangxi Administration of traditional Chinese Medicine","award":["2021Z011"],"award-info":[{"award-number":["2021Z011"]}]},{"name":"Jiangxi Provincial Natural Science Foundation","award":["20202BABL206142"],"award-info":[{"award-number":["20202BABL206142"]}]},{"name":"Jiangxi Provincial Natural Science Foundation","award":["20212BAB206012"],"award-info":[{"award-number":["20212BAB206012"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81860702"],"award-info":[{"award-number":["81860702"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82060808"],"award-info":[{"award-number":["82060808"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["82074014"],"award-info":[{"award-number":["82074014"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jiangxi University of Chinese Medicine Graduate Innovation Fund","award":["S202110412001"],"award-info":[{"award-number":["S202110412001"]}]},{"name":"Jiangxi University of Chinese Medicine Graduate Innovation Fund","award":["JZYC21S32"],"award-info":[{"award-number":["JZYC21S32"]}]},{"name":"Science and Technology Key Project of Jiangxi Provincial Department of Education","award":["GJJ201206"],"award-info":[{"award-number":["GJJ201206"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Planta Med"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Clinical studies have shown that insomnia and anxiety are usually accompanied by\n\t\t\t\t\tcardiovascular dysfunction. In traditional Chinese medicine, Schisandra\n\t\t\t\t\t\tchinensis (SC) and wine processed Schisandra chinensis (WSC) are\n\t\t\t\t\tmainly used for the treatment of dysphoria, palpitation and insomnia. However,\n\t\t\t\t\tlittle attention was paid to its mechanism. In this study, we monitored the\n\t\t\t\t\teffect of SC and WSC on the nervous system and cardiovascular system of\n\t\t\t\t\tfree-moving rats in the real-time. Our results show that SC and WSC can\n\t\t\t\t\talleviate cardiovascular dysfunction while promoting sleep, and we further\n\t\t\t\t\texplored their potential mechanisms. HPLC-QTOF-MS was used for the quality\n\t\t\t\t\tcontrol of chemical components in SC and WSC. Data sciences international (DSI)\n\t\t\t\t\tphysiological telemetry system was applied to collect the electroencephalogram\n\t\t\t\t\t(EEG), electrocardiogram (ECG) and other parameters of free-moving rats to\n\t\t\t\t\tunderstand the effects of long-term intake of SC and WSC on rats. The content of\n\t\t\t\t\tCortisol (CORT), neurotransmitters and amino acids in rat pituitary and\n\t\t\t\t\thypothalamus were analyzed by UPLC-MS to determine the activity of HPA axis. The\n\t\t\t\t\texpression of melatonin receptor MT1 was analyzed by immunofluorescence\n\t\t\t\t\ttechnique. Our results suggested that SC and WSC may play the role of promoting\n\t\t\t\t\tsleep by increasing the expression level of melatonin receptor MT1 in\n\t\t\t\t\thypothalamus, and modulate the activity of HPA axis by regulating the levels of\n\t\t\t\t\tthe related neurotransmitters and amino acid, so as to improve the abnormal\n\t\t\t\t\tcardiovascular system of rats. This study may provide theoretical support for\n\t\t\t\t\texplicating the advantages of SC and other phytomedicines in the treatment of\n\t\t\t\t\tinsomnia.<\/jats:p>","DOI":"10.1055\/a-1721-4971","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:41:16Z","timestamp":1639615276000},"page":"1311-1324","source":"Crossref","is-referenced-by-count":13,"title":["Raw and Wine Processed Schisandra chinensis Regulate\n\t\t\t\t\tNREM-Sleep and Alleviate Cardiovascular Dysfunction Associated with Insomnia by\n\t\t\t\t\tModulating HPA Axis"],"prefix":"10.1055","volume":"88","author":[{"given":"Dan","family":"Su","sequence":"first","affiliation":[{"name":"Key Laboratory of depression animal model based on TCM syndrome,\n\t\t\t\t\tJiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM\n\t\t\t\t\tfor prevention and treatment of brain diseases with cognitive impairment,\n\t\t\t\t\tJiangxi Province, Jiangxi University of Chinese Medicine, Nanchang,\n\t\t\t\t\tChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Luo","sequence":"first","affiliation":[{"name":"Key Laboratory of depression animal model based on TCM syndrome,\n\t\t\t\t\tJiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM\n\t\t\t\t\tfor prevention and treatment of brain diseases with cognitive impairment,\n\t\t\t\t\tJiangxi Province, Jiangxi University of Chinese Medicine, Nanchang,\n\t\t\t\t\tChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqi","family":"Ge","sequence":"first","affiliation":[{"name":"Key Laboratory of depression animal model based on TCM syndrome,\n\t\t\t\t\tJiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM\n\t\t\t\t\tfor prevention and treatment of brain diseases with cognitive impairment,\n\t\t\t\t\tJiangxi Province, Jiangxi University of Chinese Medicine, Nanchang,\n\t\t\t\t\tChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of depression animal model based on TCM syndrome,\n\t\t\t\t\tJiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM\n\t\t\t\t\tfor prevention and treatment of brain diseases with cognitive impairment,\n\t\t\t\t\tJiangxi Province, Jiangxi University of Chinese Medicine, Nanchang,\n\t\t\t\t\tChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Jin","sequence":"additional","affiliation":[{"name":"Key Laboratory of depression animal model based on TCM syndrome,\n\t\t\t\t\tJiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM\n\t\t\t\t\tfor prevention and treatment of brain diseases with cognitive impairment,\n\t\t\t\t\tJiangxi Province, Jiangxi University of Chinese Medicine, Nanchang,\n\t\t\t\t\tChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of depression animal model based on TCM syndrome,\n\t\t\t\t\tJiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM\n\t\t\t\t\tfor prevention and treatment of brain diseases with cognitive impairment,\n\t\t\t\t\tJiangxi Province, Jiangxi University of Chinese Medicine, Nanchang,\n\t\t\t\t\tChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruowen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Shenzhen Honsan Health Industry Group, Shenzhen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genhua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of depression animal model based on TCM syndrome,\n\t\t\t\t\tJiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM\n\t\t\t\t\tfor prevention and treatment of brain diseases with cognitive impairment,\n\t\t\t\t\tJiangxi Province, Jiangxi University of Chinese Medicine, Nanchang,\n\t\t\t\t\tChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of depression animal model based on TCM syndrome,\n\t\t\t\t\tJiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM\n\t\t\t\t\tfor prevention and treatment of brain diseases with cognitive impairment,\n\t\t\t\t\tJiangxi Province, Jiangxi University of Chinese Medicine, Nanchang,\n\t\t\t\t\tChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifu","family":"Ai","sequence":"additional","affiliation":[{"name":"Key Laboratory of depression animal model based on TCM syndrome,\n\t\t\t\t\tJiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM\n\t\t\t\t\tfor prevention and treatment of brain diseases with cognitive impairment,\n\t\t\t\t\tJiangxi Province, Jiangxi University of Chinese Medicine, Nanchang,\n\t\t\t\t\tChina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggui","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of depression animal model based on TCM syndrome,\n\t\t\t\t\tJiangxi Administration of traditional Chinese Medicine, Key Laboratory of TCM\n\t\t\t\t\tfor prevention and treatment of brain diseases with cognitive impairment,\n\t\t\t\t\tJiangxi Province, Jiangxi University of Chinese Medicine, Nanchang,\n\t\t\t\t\tChina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/S1474-4422(15)00021-6","article-title":"The\u00a0neurobiology, investigation, and treatment of chronic insomnia","volume":"14","author":"D Riemann","year":"2015","journal-title":"Lancet Neurol"},{"key":"ref2","first-page":"695","article-title":"Nonpharmacologic approaches to the management of insomnia","volume":"110","author":"R G Lande","year":"2010","journal-title":"J Am Osteopath Assoc"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/sleep\/30.2.213","article-title":"Comorbidity of chronic insomnia with medical problems","volume":"30","author":"D J Taylor","year":"2007","journal-title":"Sleep"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"103","DOI":"10.7326\/M15-1781","article-title":"Pharmacologic treatment of insomnia disorder: An evidence report for a clinical\n\t\t\t\t\tpractice guideline by the American college of physicians","volume":"165","author":"T J Wilt","year":"2016","journal-title":"Ann Intern Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.2174\/156802612801319034","article-title":"Strategies and techniques for multi-component drug design from medicinal herbs\n\t\t\t\t\tand traditional Chinese medicine","volume":"12","author":"Y Wang","year":"2012","journal-title":"Curr Top Med Chem"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4103\/imna.imna_28_21","article-title":"Traditional Chinese medicine in ameliorating diabetic kidney disease via\n\t\t\t\t\tmodulating gut microbiota","volume":"8","author":"Y Yang","year":"2021","journal-title":"Integr Med Nephrol Androl"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1177\/0269881105053309","article-title":"Medicinal plants for insomnia: A review of their pharmacology, efficacy and\n\t\t\t\t\ttolerability","volume":"19","author":"D Wheatley","year":"2005","journal-title":"J Psychopharmacol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.smrv.2007.07.007","article-title":"Restricted and disrupted sleep: Effects on autonomic function, neuroendocrine\n\t\t\t\t\tstress systems and stress responsivity","volume":"12","author":"P Meerlo","year":"2008","journal-title":"Sleep Med Rev"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.3390\/ijms18102150","article-title":"Hypothalamic-pituitary-adrenal axis modulation of glucocorticoids in the\n\t\t\t\t\tcardiovascular system","volume":"18","author":"N G Burford","year":"2017","journal-title":"Int J Mol Sci"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1161\/HYPERTENSIONAHA.116.08212","article-title":"Arousal from sleep and sympathetic excitation during wakefulness","volume":"68","author":"K S Taylor","year":"2016","journal-title":"Hypertension"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"3149","DOI":"10.1210\/jc.2015-1198","article-title":"Association of sleep duration and quality with alterations in the\n\t\t\t\t\thypothalamic-pituitary adrenocortical axis: The Multi-Ethnic Study of\n\t\t\t\t\tAtherosclerosis (MESA)","volume":"100","author":"C Castro-Diehl","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/PSY.0000000000000199","article-title":"The association between insomnia and increased future cardiovascular events: A\n\t\t\t\t\tnationwide population-based study","volume":"77","author":"C Y Hsu","year":"2015","journal-title":"Psychosom Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"374","DOI":"10.5527\/wjn.v4.i3.374","article-title":"Early renal failure as a cardiovascular disease: Focus on lipoprotein(a) and\n\t\t\t\t\tprothrombotic state","volume":"4","author":"C Catena","year":"2015","journal-title":"World J Nephrol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"149","DOI":"10.37349\/emed.2020.00011","article-title":"Nonalcoholic fatty liver disease and portal hypertension","volume":"1","author":"M Ryou","year":"2020","journal-title":"Explor Med"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.chest.2017.01.026","article-title":"Insomnia and risk of cardiovascular disease","volume":"152","author":"S Javaheri","year":"2017","journal-title":"Chest"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11101-016-9470-4","article-title":"Current knowledge of Schisandra chinensis (Turcz.) Baill. (Chinese magnolia\n\t\t\t\t\tvine) as a medicinal plant species: A review on the bioactive components,\n\t\t\t\t\tpharmacological properties, analytical and biotechnological studies","volume":"16","author":"A Szopa","year":"2017","journal-title":"Phytochem Rev"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1016\/j.biopha.2017.10.145","article-title":"An overview of neuroprotective and cognitive enhancement properties of lignans\n\t\t\t\t\tfrom Schisandra chinensis","volume":"97","author":"K Sowndhararajan","year":"2018","journal-title":"Biomed Pharmacother"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jep.2008.04.020","article-title":"Pharmacology of Schisandra chinensis Bail.: An\u00a0overview of Russian research and\n\t\t\t\t\tuses in medicine","volume":"118","author":"A Panossian","year":"2008","journal-title":"J Ethnopharmacol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"113426","DOI":"10.1016\/j.jep.2020.113426","article-title":"Raw and wine processed Schisandra chinensis attenuate anxiety like behavior via\n\t\t\t\t\tmodulating gut microbiota and lipid metabolism pathway","volume":"266","author":"Y Song","year":"2021","journal-title":"J Ethnopharmacol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jpba.2013.09.022","article-title":"Determination of monoamine and amino acid neurotransmitters and their\n\t\t\t\t\tmetabolites in rat brain samples by UFLC-MS\/MS for the study of the\n\t\t\t\t\tsedative-hypnotic effects observed during treatment with S. chinensis","volume":"88","author":"B Wei","year":"2014","journal-title":"J Pharm Biomed Anal"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/10253890.2017.1301426","article-title":"Activation of 5-HT1A receptors in the rat dorsomedial hypothalamus inhibits\n\t\t\t\t\tstress-induced activation of the hypothalamic-pituitary-adrenal axis","volume":"20","author":"C E Stamper","year":"2017","journal-title":"Stress"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s10571-008-9263-4","article-title":"GABA(B) receptors in neuroendocrine regulation","volume":"28","author":"V A Lux-Lantos","year":"2008","journal-title":"Cell Mol Neurobiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2174\/1570159X15666170720092442","article-title":"Nicotinic cholinergic system in the hypothalamus modulates the activity of the\n\t\t\t\t\thypothalamic neuropeptides during the stress response","volume":"16","author":"B Balkan","year":"2018","journal-title":"Curr Neuropharmacol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1210\/endo.134.2.7905409","article-title":"Glutamate receptors in the rat hypothalamus and pituitary","volume":"134","author":"R B Meeker","year":"1994","journal-title":"Endocrinology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1677\/JME-08-0162","article-title":"The clinical-molecular interface of somatostatin, dopamine and their receptors\n\t\t\t\t\tin pituitary pathophysiology","volume":"42","author":"D Ferone","year":"2009","journal-title":"J Mol Endocrinol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1159\/000126316","article-title":"Histamine H1 and H2 receptor activation stimulates ACTH and beta-endorphin\n\t\t\t\t\tsecretion by increasing corticotropin-releasing hormone in the hypophyseal\n\t\t\t\t\tportal blood","volume":"56","author":"A Kjaer","year":"1992","journal-title":"Neuroendocrinology"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.smrv.2010.09.001","article-title":"REM-related bradyarrhythmia syndrome","volume":"15","author":"J E Holty","year":"2011","journal-title":"Sleep Med Rev"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.2174\/1381612822666160518125810","article-title":"Gender differences in autonomic control of the cardiovascular system","volume":"22","author":"N V Pothineni","year":"2016","journal-title":"Curr Pharm Des"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1046\/j.1365-2869.2001.00263.x","article-title":"Autonomic activity during human sleep as a function of time and sleep stage","volume":"10","author":"J Trinder","year":"2001","journal-title":"J Sleep Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1093\/sleep\/31.3.311","article-title":"Asymmetry in sympathetic and vagal activities during sleep-wake transitions","volume":"31","author":"T B Kuo","year":"2008","journal-title":"Sleep"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0031-9384(97)00234-5","article-title":"Vegetative background of sleep: spectral analysis of the heart rate\n\t\t\t\t\tvariability","volume":"62","author":"U J Scholz","year":"1997","journal-title":"Physiol Behav"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"zsy047","DOI":"10.1093\/sleep\/zsy047","article-title":"Insomnia with objective short sleep duration and risk of incident cardiovascular\n\t\t\t\t\tdisease and all-cause mortality: Sleep Heart Health Study","volume":"41","author":"S M Bertisch","year":"2018","journal-title":"Sleep"},{"key":"ref33","first-page":"57","article-title":"Neuroendocrine dysregulation in primary insomnia","volume":"157","author":"A Rodenbeck","year":"2001","journal-title":"Rev Neurol (Paris)"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1037\/a0034219","article-title":"Sleep deprivation potentiates HPA axis stress reactivity in healthy adults","volume":"33","author":"J Minkel","year":"2014","journal-title":"Health Psychol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1530\/EJE-07-0455","article-title":"Glucocorticoids and cardiovascular disease","volume":"157","author":"B R Walker","year":"2007","journal-title":"Eur J Endocrinol"},{"issue":"317","key":"ref36","doi-asserted-by":"crossref","first-page":"F1536","DOI":"10.1152\/ajprenal.00372.2019","article-title":"Glucocorticoid receptor activation stimulates the sodium-chloride cotransporter\n\t\t\t\t\tand influences the diurnal rhythm of its phosphorylation","volume":"1","author":"J R Ivy","year":"2019","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1888","DOI":"10.1210\/endo-126-4-1888","article-title":"Mechanisms of serotonin receptor agonist-induced activation of the\n\t\t\t\t\thypothalamic-pituitary-adrenal axis in the rat","volume":"126","author":"A E Calogero","year":"1990","journal-title":"Endocrinology"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1159\/000124929","article-title":"Effect of cholinergic agonists and antagonists on rat hypothalamic\n\t\t\t\t\tcorticotropin-releasing hormone secretion in vitro","volume":"47","author":"A E Calogero","year":"1988","journal-title":"Neuroendocrinology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1196\/annals.1296.004","article-title":"Role of GABA and glutamate circuitry in hypothalamo-pituitary-adrenocortical\n\t\t\t\t\tstress integration","volume":"1018","author":"J P Herman","year":"2004","journal-title":"Ann N Y Acad Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s00213-009-1613-5","article-title":"Dopamine D1 and D2 dopamine receptors regulate immobilization stress-induced\n\t\t\t\t\tactivation of the hypothalamus-pituitary-adrenal axis","volume":"206","author":"X Belda","year":"2009","journal-title":"Psychopharmacology (Berl)"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3389\/fnana.2015.00161","article-title":"Atlas of the postnatal rat brain in stereotaxic coordinates","volume":"9","author":"R Khazipov","year":"2015","journal-title":"Front Neuroanat"}],"container-title":["Planta Medica"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1721-4971.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T00:07:13Z","timestamp":1667866033000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1721-4971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,15]]},"references-count":41,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2022,11,7]]},"published-print":{"date-parts":[[2022,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1721-4971","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0032-0943","1439-0221"],"issn-type":[{"value":"0032-0943","type":"print"},{"value":"1439-0221","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,12,15]]},"published":{"date-parts":[[2021,12,15]]}}}