{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:35:54Z","timestamp":1791822954115,"version":"4.3.4"},"reference-count":30,"publisher":"Georg Thieme Verlag KG","issue":"02","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Philips Healthcare"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ultraschall Med"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Since nonalcoholic fatty liver disease (NAFLD) has become the leading cause of liver disease in the Western world, clinicians need reliable noninvasive tools for the identification of NAFLD-associated fibrosis. Limited evidence on the performance of the novel shear wave elastography technique Elast-PQ (EPQ) in NAFLD is available. Method In this prospective, European multinational study we assessed the diagnostic accuracy of EPQ using vibration-controlled transient elastography (VCTE) as a reference standard. Results Among 353 NAFLD patients, 332 (94.1%) fulfilled reliability criteria of VCTE and EPQ (defined by IQR\/median \u22640.3; 41.3% female, mean age: 59 [IQR: 16.5], mean BMI: 29.0 (7.1)). 4\/353 (1.1%) and 17\/353 (4.8%) had unreliable VCTE and EPQ measurements, respectively. VCTE-based NAFLD fibrosis stages were F0\/F1: 222(66.9%), F2: 41 (12.3%), F3: 30 (9.1%), F4: 39 (11.7%). We found a strong correlation (Pearson R=0.87; p&lt;0.0001) and concordance (Lin\u2019s concordance correlation coefficient =0.792) of EPQ with VCTE. EPQ was able to identify NAFLD-fibrosis risk with the following EPQ cutoffs: \u22656.5 kPa for significant fibrosis (\u2265F2) (\u22651.47 m\/s; sensitivity: 78%; specificity: 95%; AUROC: 0.94), \u22656.9 kPa for advanced fibrosis (\u2265F3) (\u22651.52 m\/s; sens.: 88%, spec.: 89%; AUROC: 0.949), and \u226510.4 kPa for cirrhosis (F4) (\u22651.86 m\/s; sens.: 87%; spec.: 94%; AUROC: 0.949). Conclusion The point shear wave elastography technique EPQ shows excellent correlation to and concordance with VCTE. EPQ can reliably exclude NAFLD fibrosis &lt;6.0 kPa (&lt;1.41 m\/s) and indicate a high risk of advanced fibrosis \u226510.4 kPa (\u22651.86 m\/s).<\/jats:p>","DOI":"10.1055\/a-1724-7289","type":"journal-article","created":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:15:40Z","timestamp":1646093740000},"page":"169-178","source":"Crossref","is-referenced-by-count":21,"title":["Point Shear Wave Elastography by ElastPQ for Fibrosis Screening in Patients with NAFLD: A Prospective, Multicenter Comparison to Vibration-Controlled Elastography"],"prefix":"10.1055","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-8518","authenticated-orcid":false,"given":"David JM","family":"Bauer","sequence":"additional","affiliation":[{"name":"Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria"},{"name":"Division of Gastroenterology and Hepatology, Medical University of Vienna, Wien, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Matic","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6777-5949","authenticated-orcid":false,"given":"Ruxandra","family":"Mare","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology & Hepatology, Center for Advanced Research in Gastroenterology and Hepatology, University of Medicine and Pharmacy Victor Babes Timisoara, Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5075-5626","authenticated-orcid":false,"given":"Laura","family":"Maiocchi","sequence":"additional","affiliation":[{"name":"Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1807-8258","authenticated-orcid":false,"given":"David","family":"Chromy","sequence":"additional","affiliation":[{"name":"Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria"},{"name":"Division of Gastroenterology and Hepatology, Medical University of Vienna, Wien, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3901-4111","authenticated-orcid":false,"given":"Theresa","family":"M\u00fcllner-Bucsics","sequence":"additional","affiliation":[{"name":"Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria"},{"name":"Division of Gastroenterology and Hepatology, Medical University of Vienna, Wien, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2330-0017","authenticated-orcid":false,"given":"Mattias","family":"Mandorfer","sequence":"additional","affiliation":[{"name":"Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria"},{"name":"Division of Gastroenterology and Hepatology, Medical University of Vienna, Wien, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Mustapic","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1510-9223","authenticated-orcid":false,"given":"Ioan","family":"Sporea","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine II,Division of Gastroenterology & Hepatology, Center for Advanced Research in Gastroenterology and Hepatology, University of Medicine and Pharmacy Victor Babes Timisoara, Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6344-697X","authenticated-orcid":false,"given":"Giovanna","family":"Ferraioli","sequence":"additional","affiliation":[{"name":"Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivica","family":"Grgurevic","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Zagreb, Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4590-3583","authenticated-orcid":false,"given":"Thomas","family":"Reiberger","sequence":"additional","affiliation":[{"name":"Vienna Hepatic Hemodynamic Lab, Medical University of Vienna, Vienna, Austria"},{"name":"Division of Gastroenterology and Hepatology, Medical University of Vienna, Wien, Austria"},{"name":"Christian-Doppler Laboratory for Portal Hypertension and Liver Fibrosis, Medical University of Vienna, Wien, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02482.x","article-title":"Histopathological stages of non-alcoholic fatty liver disease in type 2 diabetes: Prevalences and correlated factors","author":"NC Leite","year":"2011","journal-title":"Liver Int"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28431","article-title":"Global epidemiology of nonalcoholic fatty liver disease \u2013 Meta-analytic assessment of prevalence, incidence, and outcomes","author":"ZM Younossi","year":"2016","journal-title":"Hepatology"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.05.011","article-title":"Burden of liver disease in Europe: Epidemiology and analysis of risk 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