{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:59:11Z","timestamp":1777273151727,"version":"3.51.4"},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neurol Surg B Skull Base"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objectives\u2003The frequency of endoscopic skull base surgery in pediatric patients is increasing. This study aims to systematically review the literature for endoscopic skull base surgery outcomes in children\/adolescents aged 0 to 18 years.<\/jats:p><jats:p>\n          Design\u2003A systematic review of the literature was performed in PubMed and SCOPUS databases querying studies from 2000 to 2020 using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Final inclusion criteria included: case series with more than 10 patients with pediatric patients aged \u226418 years, endoscopic or endoscopic-assisted skull base surgery, and outcomes reported.<\/jats:p><jats:p>\n          Setting\u2003This study was conducted at a tertiary care medical center.<\/jats:p><jats:p>\n          Participants\u2003Children\/adolescents aged 0 to 18 years who underwent endoscopic skull base surgery were participated in this study.<\/jats:p><jats:p>\n          Main Outcome Measures\u2003Patient demographics, pathology, reconstructive technique, intraoperative findings, intraoperative, and postoperative surgical complications were measured through this study.<\/jats:p><jats:p>\n          Results\u2003Systematic literature search yielded 287 publications. Of these, 12 studies discussing a total of 399 patients aged 0 to 18 years met inclusion criteria for final analysis. Seven of the 12 studies discussed a single pathology. The most common pathology was a skull base defect causing cerebrospinal fluid (CSF) leak. The majority of skull base repairs were made with free tissue grafts. The most common postoperative complication was CSF leak (n\u2009=\u200940). Twelve cases of meningitis occurred postoperatively with two of these episodes resulting in death.<\/jats:p><jats:p>\n          Conclusion\u2003Endoscopic skull base surgery has been performed recently in the pediatric population in a variety of disease states. Inconsistent individual-level data and reporting standards are present in existing studies posing challenges for comparative analysis. Standardized reporting will aid future reviews and meta-analysis for rare skull base pathology.<\/jats:p>","DOI":"10.1055\/a-1725-9151","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:16:09Z","timestamp":1640132169000},"page":"024-037","source":"Crossref","is-referenced-by-count":5,"title":["Outcomes in Pediatric Endoscopic Skull Base Surgery: A Systematic Review"],"prefix":"10.1055","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4636-055X","authenticated-orcid":false,"given":"Erin M.","family":"Lopez","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of North Carolina Memorial Hospitals, Chapel Hill, North Carolina, United States"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zainab","family":"Farzal","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of North Carolina Memorial 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