{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:32:41Z","timestamp":1791689561386,"version":"4.3.4"},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background Osteogenesis imperfecta (OI) is a genetic disease characterized\n                    by fragile bones and variable short stature.<\/jats:p><jats:p>\n          Method We performed a retrospective cohort study to evaluate demographic\n                    data, clinical findings, growth and pubertal characteristics, and medical\n                    treatment of 83 OI patients.<\/jats:p><jats:p>\n          Results 83 (31 female\/52 male) patients were enrolled in the\n                    study. The median follow-up duration was 4.7 (0.6\u201317.7) years. 51 out of\n                    83 patients (61.4%) received bisphosphonate therapy. The median Z-score\n                    of the bone mineral density improved in patients with OI-I and OI-III with the\n                    treatment. During follow-up, height-SDS significantly increased in both OI-I and\n                    OI-III on treatment; however, final adult height SDS of patients did not\n                    improve. The frequency of overweight and obesity was found to be increased at\n                    the last evaluation compared to the admission. The rate of precocious puberty\n                    (PP) and early puberty (EP) were 20 and 10% in girls, and they were 15.7\n                    and 47.3% in boys, respectively.<\/jats:p><jats:p>\n          Conclusion Reduced growth, significant weight gain over time due to\n                    impaired mobility, and high frequency of PP\/EP require effective\n                    interventions to improve mobility and functional parameters as early as possible\n                    in children with OI.<\/jats:p>","DOI":"10.1055\/a-1730-5412","type":"journal-article","created":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T23:48:36Z","timestamp":1644450516000},"page":"199-205","source":"Crossref","is-referenced-by-count":7,"title":["Growth and Pubertal Features in a Cohort of 83 Patients with\n                    Osteogenesis Imperfecta"],"prefix":"10.1055","volume":"234","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3466-2857","authenticated-orcid":false,"given":"Ay\u015fe P\u0131nar","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Istanbul University Istanbul Faculty of\n                    Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asl\u0131","family":"Dudakl\u0131","sequence":"additional","affiliation":[{"name":"Pediatrics, Istanbul University Istanbul Faculty of Medicine, Istanbul,\n                    Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esin Karak\u0131l\u0131\u00e7","family":"\u00d6zturan","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Istanbul University Istanbul Faculty of\n                    Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015e\u00fckran","family":"Poyrazo\u011flu","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Istanbul University Istanbul Faculty of\n                    Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Firdevs","family":"Ba\u015f","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Istanbul University Istanbul Faculty of\n                    Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feyza","family":"Darendeliler","sequence":"additional","affiliation":[{"name":"Pediatric Endocrinology, Istanbul University Istanbul Faculty of\n                    Medicine, Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,2,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"D789","DOI":"10.1093\/nar\/gku1205","article-title":"OMIM.org: Online Mendelian Inheritance in Man (OMIM(R)), an online catalog of\n                    human genes and genetic disorders","volume":"43","author":"J S Amberger","year":"2015","journal-title":"Nucleic Acids 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