{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T19:47:23Z","timestamp":1770493643256,"version":"3.49.0"},"reference-count":10,"publisher":"Georg Thieme Verlag KG","issue":"14","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:p>\n            Objective\u2003The study aimed to report a novel coronavirus disease 2019 (COVID-19)-associated multisystem inflammatory syndrome in children (MIS-C) in a neonate found to have an atypical diffuse thickening in coronary artery walls whose diagnosis required a multi-imaging approach.<\/jats:p><jats:p>\n            Study Design\u2003A neonate presented at birth with multiple organ involvement and coronary artery anomalies. A diagnosis of MIS-C associated with COVID-19 was supported by maternal severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) infection during pregnancy, and by the presence of both immunoglobulin (Ig)-G against SARS-CoV-2 and spike-specific memory B-cells response in the neonatal blood. Other plausible causes of the multiple organ involvement were excluded.<\/jats:p><jats:p>\n            Result\u2003At admission, a severe coronary artery dilatation was identified on echocardiography, supporting the diagnosis of the MIS-C Kawasaki-like disease; however, coronary artery internal diameters were found to be normal using cardiac computed tomography angiography. At discharge, comparing the two imaging techniques each other, the correct diagnosis resulted to be an abnormal thickening in coronary arterial walls. These findings suggest that the inflammatory process affecting the coronary arterial wall in MIS-C could result not only in typical coronary artery lesions such as dilatation of the lumen or aneurysms development but also in abnormal thickening of the coronary artery wall.<\/jats:p><jats:p>\n            Conclusion\u2003Our case provides an alert for pediatric cardiologists about the complexity to assess coronary artery involvement in MIS-C and raises the question that whether an abnormal vascular remodeling, with normal inner diameters, is to be considered like coronary artery dilatation for risk stratification.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1733-4163","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T23:39:21Z","timestamp":1641598761000},"page":"1514-1518","source":"Crossref","is-referenced-by-count":7,"title":["COVID-19-Associated Multisystem Inflammatory Syndrome in a Neonate with Atypical Coronary Artery Involvement"],"prefix":"10.1055","volume":"29","author":[{"given":"Simonetta","family":"Costa","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica, Fondazione Policlinico Universitario A. Gemelli Istituto Di Ricovero E Cura A Carattere Scientifico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelica B.","family":"Delogu","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica, Fondazione Policlinico Universitario A. Gemelli Istituto Di Ricovero E Cura A Carattere Scientifico, Rome, Italy"},{"name":"Dipartimento di Scienze della Vita e Sanit\u00e0 Pubblica, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthea","family":"Bottoni","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica, Fondazione Policlinico Universitario A. Gemelli Istituto Di Ricovero E Cura A Carattere Scientifico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Velia","family":"Purcaro","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica, Fondazione Policlinico Universitario A. Gemelli Istituto Di Ricovero E Cura A Carattere Scientifico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"D'Andrea","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica, Fondazione Policlinico Universitario A. Gemelli Istituto Di Ricovero E Cura A Carattere Scientifico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Paladini","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica, Fondazione Policlinico Universitario A. Gemelli Istituto Di Ricovero E Cura A Carattere Scientifico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Muto","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Vita e Sanit\u00e0 Pubblica, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Marano","sequence":"additional","affiliation":[{"name":"Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli Istituto Di Ricovero E Cura A Carattere Scientifico, Rome, Italy"},{"name":"Dipartimento di Scienze radiologiche ed ematologiche, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Savino","sequence":"additional","affiliation":[{"name":"Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Fondazione Policlinico Universitario A. Gemelli Istituto Di Ricovero E Cura A Carattere Scientifico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurelio","family":"Secinaro","sequence":"additional","affiliation":[{"name":"Department of Imaging, Ospedale Pediatrico Bambino Ges\u00f9, Istituto Di Ricovero E Cura A Carattere Scientifico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"De Benedetti","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Laboratory of Immuno-Rheumatology, Ospedale Pediatrico Bambino Ges\u00f9, Istituto Di Ricovero E Cura A Carattere Scientifico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita","family":"Carsetti","sequence":"additional","affiliation":[{"name":"Diagnostic Immunology Research Unit, Multimodal Medicine Research Area, Ospedale Pediatrico Bambino Ges\u00f9, Istituto Di Ricovero E Cura A Carattere Scientifico, Rome, Italy"},{"name":"Microbiology and Diagnostic Immunology Unit, Ospedale Pediatrico Bambino Ges\u00f9, Istituto Di Ricovero E Cura A Carattere Scientifico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva Piano","family":"Mortari","sequence":"additional","affiliation":[{"name":"Diagnostic Immunology Research Unit, Multimodal Medicine Research Area, Ospedale Pediatrico Bambino Ges\u00f9, Istituto Di Ricovero E Cura A Carattere Scientifico, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Spanu","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze di Laboratorio e Infettivologiche, Fondazione Policlinico Universitario A. Gemelli Istituto Di Ricovero E Cura A Carattere Scientifico, Rome, Italy"},{"name":"Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Vento","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze della Salute della Donna, del Bambino e di Sanit\u00e0 Pubblica, Fondazione Policlinico Universitario A. Gemelli Istituto Di Ricovero E Cura A Carattere Scientifico, Rome, Italy"},{"name":"Dipartimento di Scienze della Vita e Sanit\u00e0 Pubblica, Universit\u00e0 Cattolica del Sacro Cuore, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"issue":"04","key":"ref4","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1002\/art.41616","article-title":"American College of Rheumatology Clinical Guidance for multisystem inflammatory syndrome in children associated with SARS-CoV-2 and hyperinflammation in pediatric COVID-19: version 2","volume":"73","author":"L A Henderson","year":"2021","journal-title":"Arthritis Rheumatol"},{"issue":"06","key":"ref5","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1055\/s-0041-1726318","article-title":"Presumptive neonatal multisystem inflammatory syndrome in children associated with coronavirus disease 2019","volume":"38","author":"A A Divekar","year":"2021","journal-title":"Am J Perinatol"},{"issue":"04","key":"ref6","doi-asserted-by":"crossref","first-page":"e162","DOI":"10.1097\/INF.0000000000003054","article-title":"COVID-19-related potential multisystem inflammatory syndrome in childhood in a neonate presenting as persistent pulmonary hypertension of the newborn","volume":"40","author":"R Khaund Borkotoky","year":"2021","journal-title":"Pediatr Infect Dis J"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S2352-4642(21)00055-9","article-title":"Multisystem inflammatory syndrome in a neonate, temporally associated with prenatal exposure to SARS-CoV-2: a case report","volume":"5","author":"M Kappanayil","year":"2021","journal-title":"Lancet Child Adolesc Health"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1093\/jpids\/piaa133","article-title":"Maternal SARS-CoV-2 infection associated to systemic inflammatory response and pericardial effusion in the newborn: a case report","volume":"10","author":"A RO Lima","year":"2021","journal-title":"J Pediatric Infect Dis Soc"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"652857","DOI":"10.3389\/fped.2021.652857","article-title":"Case report: neonatal multi-system inflammatory syndrome associated with SARS-CoV-2 exposure in two cases from Saudi Arabia","volume":"9","author":"L A Shaiba","year":"2021","journal-title":"Front Pediatr"},{"issue":"07","key":"ref10","first-page":"572","article-title":"Neonatal multisystem inflammatory syndrome (MIS-N) associated with prenatal maternal SARS-CoV-2: a case series","volume":"8","author":"R Pawar","year":"2021","journal-title":"Children (Basel)"},{"key":"ref11","first-page":"x","article-title":"Neonatal multisystem inflammatory syndrome secondary to SARS-CoV-2 infection","volume":"13","author":"S Diggikar","year":"2021","journal-title":"J Paediatr Child Health"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3233\/NPM-210839","article-title":"Multisystem inflammatory syndrome with persistent neutropenia in neonate exposed to SARS-CoV-2 virus: a case report and review of literature","author":"K Diwakar","year":"2021","journal-title":"J Neonatal Perinatal Med"},{"issue":"01","key":"ref13","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s12872-021-02090-7","article-title":"Intimal thickening and disruption of the media occur in the arterial walls of coronary arteries not associated with coronary arterial aneurysms in patients with Kawasaki disease","volume":"21","author":"T Tsuchihashi","year":"2021","journal-title":"BMC Cardiovasc Disord"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1733-4163.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T23:28:38Z","timestamp":1664494118000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1733-4163"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,7]]},"references-count":10,"journal-issue":{"issue":"14","published-online":{"date-parts":[[2022,9,29]]},"published-print":{"date-parts":[[2022,10]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1733-4163","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,7]]},"published":{"date-parts":[[2022,1,7]]}}}