{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:34:10Z","timestamp":1740126850811,"version":"3.37.3"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Objective This study aimed to investigate the ability of the immune system\n                    assessment questionnaire (ISAQ) to predict adrenal crisis (AC) and infectious\n                    events in patients with primary adrenal insufficiency (PAI).<\/jats:p><jats:p>\n          Design This was a prospective single-centre study over three years.<\/jats:p><jats:p>\n          Methods Patients answered the ISAQ at baseline and were seen every\n                    4\u20136 months in the endocrine outpatient clinic. At each visit previous\n                    infectious periods which required an increase in daily glucocorticoid dosage and\n                    AC were reported and documented. Seventy-five patients with PAI (53 women; 43\n                    patients with autoimmune PAI, 20 patients with salt-wasting congenital adrenal\n                    hyperplasia and 12 patients who underwent bilateral adrenalectomy) were\n                    analysed. Due to the COVID-19 pandemic and consecutive lockdown measures, the\n                    data were analysed separately for March 2018 to March 2020 (period 1), and March\n                    2020 to March 2021 (period 2).<\/jats:p><jats:p>\n          Results During period 1 the ISAQ score significantly correlated with the\n                    number of reported infectious events (r=0.351; p&lt;0.01), but not\n                    during period 2 (r=0.059, p=0.613), in which the number of\n                    infectious events per patient-year significantly decreased (1.1\u00b10.1 vs\n                    0.4\u00b10.1; p&lt;0.001). The frequency of AC decreased from 8.8 to 2.4\n                    per 100 patient-years between the two study periods. The ISAQ score was not\n                    different between patients with or without AC.<\/jats:p><jats:p>\n          Conclusions The ISAQ score does not identify patients prone to ACs. The\n                    COVID-19 pandemic and consecutive lockdown measures significantly diminished the\n                    frequency of infectious events and ACs.<\/jats:p>","DOI":"10.1055\/a-1734-2466","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T23:50:02Z","timestamp":1646351402000},"page":"554-560","source":"Crossref","is-referenced-by-count":3,"title":["The ISAQ Score Does Not Predict Adrenal Crisis in Patients with\n                    Primary Adrenal Insufficiency"],"prefix":"10.1055","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4028-1671","authenticated-orcid":false,"given":"Marcus","family":"Quinkler","sequence":"additional","affiliation":[{"name":"Endocrinology in Charlottenburg, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Kienitz","sequence":"additional","affiliation":[{"name":"Endocrinology in Charlottenburg, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3912","DOI":"10.1210\/jc.2007-0685","article-title":"Impaired subjective health status in 256 patients with adrenal insufficiency on\n                    standard therapy based on cross-sectional analysis","volume":"92","author":"S Hahner","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.1210\/jc.2006-0076","article-title":"Premature mortality in patients with Addison\u2019s disease: A\n                    population-based study","volume":"91","author":"R Bergthorsdottir","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.1210\/jc.2009-1368","article-title":"Wolff ABet al. 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Diabetes"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1734-2466.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T22:59:49Z","timestamp":1660258789000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1734-2466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,3]]},"references-count":36,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2022,8,11]]},"published-print":{"date-parts":[[2022,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1734-2466","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0947-7349","1439-3646"],"issn-type":[{"type":"print","value":"0947-7349"},{"type":"electronic","value":"1439-3646"}],"subject":[],"published":{"date-parts":[[2022,3,3]]}}}