{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:56:29Z","timestamp":1789419389466,"version":"build-2803163510"},"reference-count":19,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endoscopy"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:p>\n            Background\u2002Endoscopic clip placement is technically challenging using a duodenoscope, limiting their application for treatment of bleeding after endoscopic papillectomy. This study evaluated the efficacy of newly designed clips to prevent bleeding after endoscopic papillectomy.<\/jats:p><jats:p>\n            Methods\u2002Patients (n\u200a=\u200a80) with suspected benign adenomas on the major papilla who were scheduled for endoscopic papillectomy with or without clipping were randomized. A new duodenoscope-compatible clip capable of being rotated, reopened, and repeatedly repositioned was used. The primary end point was incidence of delayed bleeding.<\/jats:p><jats:p>\n            Results\u2002The clipping procedure was successful in all patients. The incidence of delayed bleeding was nonsignificantly higher in the no-clipping group than in the clipping group (31.6\u200a% [95\u200a% confidence interval (CI) 19.1\u201347.5] vs. 15.0\u200a% [95\u200a%CI 7.1\u201329.1]). The incidence of post-endoscopic retrograde cholangiopancreatography pancreatitis did not differ significantly between the groups (clipping vs. no-clipping: 17.5\u200a% [95\u200a%CI 8.7\u201331.9] vs. 5.3\u200a% [95\u200a%CI 1.5\u201317.3]), and all cases were mild.<\/jats:p><jats:p>\n            Conclusions\u2002Placement of the newly designed rotatable clip was technically feasible and tended to have a protective effect by preventing delayed bleeding after endoscopic papillectomy, although statistical significance was not reached.<\/jats:p>","DOI":"10.1055\/a-1737-3843","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T23:53:32Z","timestamp":1644623612000},"page":"787-794","source":"Crossref","is-referenced-by-count":26,"title":["Effect of prophylactic endoscopic clipping for prevention of delayed bleeding after endoscopic papillectomy for ampullary neoplasm: a multicenter randomized trial"],"prefix":"10.1055","volume":"54","clinical-trial-number":[{"clinical-trial-number":"kct0003245","registry":"10.18810\/cris"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1603-7468","authenticated-orcid":false,"given":"Se Woo","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hallym University College of Medicine, Hwaseong-si, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Jun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Seok","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inha University Hospital, Inha University School of Medicine, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae Hyuk","family":"Jun","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Eulji University College of Medicine, Daejeon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Young","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Inje University Seoul Paik Hospital, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Wook","family":"Oh","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Soo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung-Hwan","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0016-5107(03)02366-6","article-title":"Endoscopic management of adenoma of the major duodenal papilla","volume":"59","author":"M F Catalano","year":"2004","journal-title":"Gastrointest Endosc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.gie.2009.04.015","article-title":"Papillectomy for ampullary neoplasm: results of a single referral center over a 10-year period","volume":"70","author":"S Irani","year":"2009","journal-title":"Gastrointest 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Kagawa","year":"2020","journal-title":"J Gastroenterol Hepatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1055\/s-0030-1256229","article-title":"The arterial supply of the major duodenal papilla and its relevance to endoscopic sphincterotomy","volume":"43","author":"S A Mirjalili","year":"2011","journal-title":"Endoscopy"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1055\/a-0587-5228","article-title":"Outcomes after endoscopic resection of large laterally spreading lesions of the papilla and conventional ampullary adenomas are equivalent","volume":"50","author":"A Klein","year":"2018","journal-title":"Endoscopy"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.gie.2005.04.053","article-title":"Endoscopic resection of benign tumors of the duodenal papilla without and with intraductal growth","volume":"62","author":"S Bohnacker","year":"2005","journal-title":"Gastrointest 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