{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:03:41Z","timestamp":1778717021094,"version":"3.51.4"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"08","funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"crossref","award":["CIHR # PJT 148716"],"award-info":[{"award-number":["CIHR # PJT 148716"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006095","name":"Southern and Eastern Norway Regional Health Authority","doi-asserted-by":"crossref","award":["2015112"],"award-info":[{"award-number":["2015112"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction\u2003The Villalta scale is the endorsed tool to diagnose and grade the severity of postthrombotic syndrome (PTS); however, assessing presence and severity of PTS is time-consuming and relies on both the clinician and patient's assessments. The patient-reported Villalta scale version 2 (PRV2) is a visually assisted form that enables patients to self-assess presence and severity of PTS. Herein, we report on external validation of this tool.<\/jats:p><jats:p>\n          Methods\u2003We assessed the agreement and kappa values of PRV2 to diagnose and assess severity of PTS compared with the original Villalta score in a cohort of 181 patients (196 limbs) who participated in the SAVER pilot randomized control trial. Presence of PTS was defined as PRV2 \u22655 or a Villalta score \u22655.<\/jats:p><jats:p>\n          Results\u2003PTS prevalence was 42% using PRV2 and 33% using the Villalta scale. The corresponding kappa and percentage agreement were 0.60 (95% confidence interval [CI]: 0.49\u20130.71) and 81% (95% CI: 76\u201387), respectively. Kappa values and percentage agreements between PRV2 and Villalta scale increased with increasing severity of PTS. The sensitivity of PRV2 to detect PTS of any severity was 84% (95% CI: 73\u201392) with a specificity of 79% (95% CI: 71\u201386).<\/jats:p><jats:p>\n          Conclusion\u2003We conclude that the PRV2 is an acceptable tool for diagnosing and grading the severity of PTS.<\/jats:p>","DOI":"10.1055\/a-1738-1313","type":"journal-article","created":{"date-parts":[[2022,1,12]],"date-time":"2022-01-12T23:51:45Z","timestamp":1642031505000},"page":"1379-1383","source":"Crossref","is-referenced-by-count":7,"title":["External Validation of the Patient-Reported Villalta Scale for the Diagnosis of Postthrombotic Syndrome"],"prefix":"10.1055","volume":"122","clinical-trial-number":[{"clinical-trial-number":"nct02679664","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Clive","family":"Kearon","sequence":"first","affiliation":[{"name":"Department of Medicine, McMaster University, Hamilton, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Ng","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada"},{"name":"Department of Haematology, Liverpool Hospital, Liverpool, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc A.","family":"Rodger","sequence":"additional","affiliation":[{"name":"Department of Medicine, Faculty of Medicine, McGill University, Montr\u00e9al, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waleed","family":"Ghanima","sequence":"additional","affiliation":[{"name":"Department of Research, Ostfold Hospital Trust, Norway"},{"name":"Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Kovacs","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, University of Western Ontario, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sudeep","family":"Shivakumar","sequence":"additional","affiliation":[{"name":"Division of Hematology, Nova Scotia Health Authority, Halifax, Nova Scotia, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan R.","family":"Kahn","sequence":"additional","affiliation":[{"name":"Department of Medicine, McGill University, Montreal, Quebec, Canada"},{"name":"Division of Clinical Epidemiology, Lady Davis Institute, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5556-8099","authenticated-orcid":false,"given":"Per Morten","family":"Sandset","sequence":"additional","affiliation":[{"name":"Department of Haematology, University of Oslo and Oslo University Hospital, Oslo, Norway"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ranjeeta","family":"Mallick","sequence":"additional","affiliation":[{"name":"The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0227-1245","authenticated-orcid":false,"given":"Aur\u00e9lien","family":"Delluc","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"issue":"03","key":"ref1","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1365-2141.2009.07601.x","article-title":"Post-thrombotic syndrome: prevalence, prognostication and need for progress","volume":"145","author":"P Prandoni","year":"2009","journal-title":"Br J Haematol"},{"issue":"S 04","key":"ref2","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/S0049-3848(09)70146-X","article-title":"Valvular dysfunction and venous obstruction in the post-thrombotic syndrome","volume":"123","author":"S Vedantham","year":"2009","journal-title":"Thromb Res"},{"issue":"05","key":"ref3","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1111\/j.1538-7836.2009.03294.x","article-title":"Definition of post-thrombotic syndrome of the leg for use in clinical investigations: a recommendation for standardization","volume":"7","author":"S R Kahn","year":"2009","journal-title":"J Thromb Haemost"},{"issue":"05","key":"ref4","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/j.1538-7836.2009.03339.x","article-title":"Measurement properties of the Villalta scale to define and classify the severity of the post-thrombotic syndrome","volume":"7","author":"S R Kahn","year":"2009","journal-title":"J Thromb Haemost"},{"issue":"02","key":"ref5","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1160\/th15-04-0318","article-title":"Development and validation of a tool for patient reporting of symptoms and signs of the post-thrombotic syndrome","volume":"115","author":"K K Utne","year":"2016","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref6","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/jth.15537","article-title":"Statins for venous event reduction in patients with venous thromboembolism: a multicenter randomized controlled pilot trial assessing feasibility","volume":"20","author":"A Delluc","year":"2022","journal-title":"J Thromb Haemost"},{"issue":"01","key":"ref7","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1182\/asheducation-2016.1.413","article-title":"The post-thrombotic syndrome","volume":"2016","author":"S R Kahn","year":"2016","journal-title":"Hematology (Am Soc Hematol Educ Program)"},{"key":"ref8","first-page":"158a","article-title":"Assessment of validity and reproducibility of a clinical scale for the post-thrombotic syndrome","volume":"24","author":"S Villalta","year":"1994","journal-title":"Haemostasis"},{"issue":"05","key":"ref9","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1503\/cmaj.080493","article-title":"Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy","volume":"179","author":"M A Rodger","year":"2008","journal-title":"CMAJ"},{"issue":"01","key":"ref10","first-page":"164","article-title":"Inter-observer reliability of measures to assess the post-thrombotic syndrome","volume":"100","author":"M A Rodger","year":"2008","journal-title":"Thromb Haemost"},{"issue":"01","key":"ref11","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1177\/0963721411429456","article-title":"Patients' perceptions of their illness","volume":"21","author":"K J Petrie","year":"2012","journal-title":"Curr Dir Psychol Sci"}],"container-title":["Thrombosis and Haemostasis"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1738-1313.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T23:21:57Z","timestamp":1661124117000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1738-1313"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,12]]},"references-count":11,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2022,8,21]]},"published-print":{"date-parts":[[2022,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1738-1313","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0340-6245","2567-689X"],"issn-type":[{"value":"0340-6245","type":"print"},{"value":"2567-689X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,1,12]]},"published":{"date-parts":[[2022,1,12]]}}}