{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:47:55Z","timestamp":1790380075416,"version":"4.1.0"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background To evaluate the macular and optic disc vascular changes in vitamin B12 deficiency anemia.<\/jats:p>\n                  <jats:p>Methods A total of 24 patients with vitamin B12 deficiency anemia and 24 healthy controls were involved in this study. All participants were evaluated for central macular thickness\n\t\t\t\t\t(CMT), peripapillary retina nerve fiber layer (RNFL) thickness, foveal avascular zone (FAZ) area, macular vessel density (VD) in superficial capillary plexus (SCP) and deep capillary plexus\n\t\t\t\t\t(DCP), choriocapillaris flow area, and optic disc radial peripapillary capillary (RPC) VD using optic coherence tomography (OCT) and optic coherence tomography angiography (OCTA). Metabolic\n\t\t\t\t\tparameters were also noted.<\/jats:p>\n                  <jats:p>Results Temporal RNFL thickness significantly decreased in the B12 deficiency anemia group (p\u2009=\u20090.04). Choriocapillaris flow area (p\u2009=\u20090.045) and macular vessel density in both SCP\n\t\t\t\t\t(p\u2009=\u20090.022) and DCP (p\u2009=\u20090.018) markedly declined in the study group. Optic disc RPC VD in the B12 deficiency anemia group was lower in all regions compared to that of the control group, but\n\t\t\t\t\tthe difference was not statistically significant (p\u2009&gt;\u20090.05). There were significant positive correlations between choriocapillaris flow area, macular VD, vitamin B12, and hemoglobin.<\/jats:p>\n                  <jats:p>Conclusion Retinal vascular alterations were observed in B12 deficiency anemia, and OCTA may be beneficial in the diagnosis and follow-up of ocular complications in these cases.<\/jats:p>","DOI":"10.1055\/a-1738-9941","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T19:56:03Z","timestamp":1648065363000},"page":"92-98","source":"Crossref","is-referenced-by-count":5,"title":["Effects of B12 Deficiency Anemia on Radial Peripapillary and Macular Vessel Density: An Optical Coherence Tomography Angiography (OCTA) Study"],"prefix":"10.1055","volume":"240","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8275-1507","authenticated-orcid":false,"given":"Semra","family":"Koca","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Kayseri City Education and Research Hospital, Kocasinan\/Kayseri, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhan","family":"Bozkurt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"Dogan","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filiz","family":"Yavasoglu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcr","family":"Erogul","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayten Kocaman","family":"Bulut","sequence":"additional","affiliation":[{"name":"Department Augenheilkunde, Medizentrum Eckert MVZ GmbH, Bruchsal, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1146\/annurev.nutr.24.012003.132440","article-title":"Vitamin B12 deficiency as a worldwide problem","volume":"24","author":"S P Stabler","year":"2004","journal-title":"Annu Rev Nutr"},{"key":"ref2","first-page":"979","article-title":"Vitamin B12 deficiency","volume":"67","author":"R Oh","year":"2003","journal-title":"Am Fam Physician"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1111\/j.1753-4887.2004.tb00070.x","article-title":"Physiology of folate and vitamin B12 in health and disease","volume":"62","author":"P J 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