{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T18:07:05Z","timestamp":1776276425102,"version":"3.50.1"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose To report the efficacy of postoperative diclofenac eye drops for pain reduction in patients undergoing topography-guided transepithelial surface ablation.<\/jats:p><jats:p>\n          Methods Retrospective consecutive case series of patients undergoing topography-guided transepithelial surface ablation for refractive myopia treatment using a 1 KHz excimer laser.\n\t\t\t\t\tPatients were divided into three groups. Group 1 did not receive any diclofenac drops, group 2 received one diclofenac drop postoperatively (day 1), and group 3 received one drop of\n\t\t\t\t\tdiclofenac postoperatively (day 1) and on the day after treatment (day 2). Postoperative pain was self-assessed by patients per eye daily for the first 4 consecutive days (days 1 to 4) after\n\t\t\t\t\tthe treatment using the visual analogue scale (VAS). We compared VAS with respect to the use of additional oral or topical treatment as well as VAS with regards to the total amount of\n\t\t\t\t\tablated tissue (&lt;\u200950\u2009\u00b5m, 50\u200a\u2013\u200a100\u2009\u00b5m, \u2265\u2009100\u2009\u00b5m) among the groups.<\/jats:p><jats:p>\n          Results We enrolled 163 eyes of 163 patients (55.0% female), with a mean age of 31.3 years (SD \u00b1\u20096.6; range 21\u200a\u2013\u200a68). We excluded 16 patients who applied other additional analgesics.\n\t\t\t\t\tGroup 1 comprised 35 eyes (21%), group 2 had 21 eyes (13%), and group 3 consisted of 107 eyes (66%). Median pain score (VAS) was 5 (range 0, 10) in group 1, which was higher than in groups 2\n\t\t\t\t\t(median 1, range 0 to 7) and 3 (median 1.5, range 0 to 7) on the day of surgery (p\u2009&lt;\u20090.0001). Percentage of patients using an additional oral NSAID on days 1 and 2 was significantly\n\t\t\t\t\thigher in group 1 (69\/83%) when compared to groups 2 (24\/43%) or 3 (31\/49%) (p\u2009&lt;\u20090.001 day 1, p\u2009=\u20090.001 day 2). No correlation was found between pain sensation and maximum ablation depth\n\t\t\t\t\t(Spearman correlation p\u2009&gt;\u20090.05).<\/jats:p><jats:p>\n          Conclusion The instillation of one drop of diclofenac after topography-guided transepithelial surface ablation reduced subjective pain sensation according to VAS and decreased the\n\t\t\t\t\tneed for additional topical anesthetic drops or oral NSAID.<\/jats:p>","DOI":"10.1055\/a-1739-0410","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T23:56:03Z","timestamp":1648079763000},"page":"386-389","source":"Crossref","is-referenced-by-count":1,"title":["Efficacy of Diclofenac in Pain Reduction after Topography-Guided Transepithelial Surface Ablation"],"prefix":"10.1055","volume":"239","author":[{"given":"Moritz","family":"Jost","sequence":"additional","affiliation":[{"name":"Augenklinik, Luzerner Kantonsspital, Luzern, Switzerland"},{"name":"Ophthalmology, Faculty of Medicine, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Pfaeffli","sequence":"additional","affiliation":[{"name":"Augenklinik, Luzerner Kantonsspital, Luzern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Kaufmann","sequence":"additional","affiliation":[{"name":"Augenklinik, Luzerner Kantonsspital, Luzern, Switzerland"},{"name":"Ophthalmology, Faculty of Medicine, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Reichmuth","sequence":"additional","affiliation":[{"name":"Augenklinik, Luzerner Kantonsspital, Luzern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Thiel","sequence":"additional","affiliation":[{"name":"Augenklinik, Luzerner Kantonsspital, Luzern, Switzerland"},{"name":"Ophthalmology, Faculty of Medicine, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Baenninger","sequence":"additional","affiliation":[{"name":"Augenklinik, Luzerner Kantonsspital, Luzern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/s41433-020-1096-5","article-title":"Refractive surgery beyond 2020","volume":"35","author":"M Ang","year":"2021","journal-title":"Eye (Lond)"},{"issue":"12","key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012687.pub2","article-title":"Wavefront excimer laser refractive surgery for adults with refractive errors","author":"S M Li","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1007\/s004179900111","article-title":"Manifest diabetes and keratoconus: 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Klimek","year":"2017","journal-title":"Allergo J Int"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr 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