{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T19:53:29Z","timestamp":1789588409973,"version":"build-2803163510"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"03","funder":[{"name":"JSPS KAKENHI Grant Number","award":["21K07508"],"award-info":[{"award-number":["21K07508"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacopsychiatry"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Introduction This study investigated combined prescriptions of drugs for\n                    mood disorders and physical comorbidities that need special attention in the\n                    light of frequent physical comorbidities in patients with mood disorders.<\/jats:p>\n                  <jats:p>Methods We used the claims sampling data of 581,990 outpatients in January\n                    2015 from the National Database of Health Insurance Claims and Specific Health\n                    Checkups of Japan. Fisher\u2019s exact test was performed to compare the\n                    prescription rates of non-steroidal anti-inflammatory drugs (NSAIDs),\n                    loop\/thiazide diuretics, angiotensin-converting enzyme inhibitors,\n                    and\/or angiotensin II receptor blockers between lithium users and age-\n                    and sex-matched non-lithium users; NSAIDs, antiplatelet drugs, and\/or\n                    anticoagulants between selective serotonin reuptake inhibitor\n                    (SSRI)\/serotonin-noradrenaline reuptake inhibitor (SNRI) users and\n                    non-users; warfarin between mirtazapine users and non-users; and the proportions\n                    of patients in the two groups with a diagnosis of somatic conditions for which\n                    these medications were indicated and actually received them. A Bonferroni\n                    corrected p-value of&lt;0.05\/3 was considered statistically\n                    significant.<\/jats:p>\n                  <jats:p>Results Prescriptions of the above-mentioned medications were less\n                    frequent in lithium and mirtazapine users and comparable in SSRI\/SNRI\n                    users, compared to non-users (18.3 vs. 31.9%,\n                        p=7.6\u00d710\u221210; 0.78 vs. 1.65%,\n                    p=0.01; 23.1 vs. 24.1%, p=0.044). In a subgroup of\n                    patients with somatic diseases for which these medications were indicated, the\n                    prescription rates were comparable in lithium and mirtazapine users and higher\n                    in SSRI\/SNRI users compared to non-users (28.0 vs. 29.4%,\n                    p=0.73; 4.7 vs. 7.4%, p=0.28; 35.6 vs. 33.4%,\n                    p=0.0026).<\/jats:p>\n                  <jats:p>Discussion Pharmacotherapy with drugs for mood disorders and physical\n                    comorbidities that require attention was commonly observed in clinical\n                    practice.<\/jats:p>","DOI":"10.1055\/a-1744-6582","type":"journal-article","created":{"date-parts":[[2022,2,4]],"date-time":"2022-02-04T19:52:09Z","timestamp":1644004329000},"page":"157-162","source":"Crossref","is-referenced-by-count":2,"title":["Drug Combinations for Mood Disorders and Physical Comorbidities That\n                    Need Attention: A Cross-Sectional National Database Survey"],"prefix":"10.1055","volume":"55","author":[{"given":"Shin","family":"Kuramochi","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Keio University School of Medicine,\n                    Tokyo, Japan"},{"name":"Department of Neuropsychiatry, Kawasaki Municipal Hospital, Kanagawa,\n                    Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taisuke","family":"Yatomi","sequence":"first","affiliation":[{"name":"Department of Neuropsychiatry, Keio University School of Medicine,\n                    Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahito","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Keio University School of Medicine,\n                    Tokyo, Japan"},{"name":"Melbourne Neuropsychiatry Centre, Department of Psychiatry, The\n                    University of Melbourne, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyoshi","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Keio University School of Medicine,\n                    Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Mimura","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Keio University School of Medicine,\n                    Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Keio University School of Medicine,\n                    Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,2,4]]},"reference":[{"key":"ref1","first-page":"165","article-title":"70 Years of Research and 50 Years of Lithium Clinics: From Serendipity to Gold\n                    Standard in Mood Disorders","volume":"51(5)","author":"M Bauer","journal-title":"Pharmacopsychiatry 2018 Sep"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1111\/bdi.12959","article-title":"Pharmacological management of bipolar disorder: Japanese expert consensus","volume":"22","author":"H Sakurai","year":"2020","journal-title":"Bipolar Disord"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.jad.2020.01.149","article-title":"Pharmacological management of depression: Japanese expert consensus","volume":"266","author":"H Sakurai","year":"2020","journal-title":"J Affect Disord"},{"key":"ref5","first-page":"9","article-title":"Comorbidity Patterns of Mood Disorders in Adult Inpatients: Applying Association\n                    Rule Mining","author":"S Cha","journal-title":"Healthcare (Basel) 2021 Sep 3"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1038\/s41380-019-0486-1","article-title":"Association between major depressive disorder and multiple disease outcomes: A\n                    phenome-wide Mendelian randomisation study in the UK Biobank","volume":"25","author":"A Mulugeta","year":"2020","journal-title":"Mol Psychiatry"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1017\/cjn.2020.17","article-title":"Common comorbidities of stroke in the Canadian population","volume":"47","author":"A H Elamy","year":"2020","journal-title":"Can J Neurol Sci"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/HRP.0000000000000198","article-title":"Pain and depression: A systematic review","volume":"26","author":"W W IsHak","year":"2018","journal-title":"Harv Rev Psychiatry"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1055\/a-1157-9433","article-title":"Drug-drug interactions between lithium and cardiovascular as well as\n                    anti-inflammatory drugs","volume":"53","author":"M Scherf-Clavel","year":"2020","journal-title":"Pharmacopsychiatry"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.4088\/JCP.09r05786blu","article-title":"Serotonin reuptake inhibitor antidepressants and abnormal bleeding: A review for\n                    clinicians and a reconsideration of mechanisms","volume":"71","author":"C Andrade","year":"2010","journal-title":"J Clin Psychiatry"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.cgh.2014.06.021","article-title":"Use of selective serotonin reuptake inhibitors and risk of upper\n                    gastrointestinal bleeding: A systematic review and meta-analysis","volume":"13","author":"H Y Jiang","year":"2015","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1248\/bpb.b20-00698","article-title":"Antiplatelet effect of mirtazapine via co-blocking of the 5-HT(2A) and\n                    \u03b1(2)-adrenergic receptors on platelets","volume":"44","author":"Y Kawano","year":"2021","journal-title":"Biol Pharm Bull"},{"key":"ref17","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2018"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2147\/IJGM.S146830","article-title":"First-visit patients without a referral to the Department of Internal Medicine\n                    at a medium-sized acute care hospital in Japan: An observational study","volume":"10","author":"N Kajiwara","year":"2017","journal-title":"Int J Gen Med"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1097\/JCP.0000000000000932","article-title":"Psychopharmacology in Japan: An overview and recent topics","volume":"38","author":"K Yoshida","year":"2018","journal-title":"J Clin Psychopharmacol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1001\/archpsyc.60.1.39","article-title":"Using chronic pain to predict depressive morbidity in the general\n                    population","volume":"60","author":"M M Ohayon","year":"2003","journal-title":"Arch Gen Psychiatry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/ijs.12357","article-title":"Part I: Frequency of depression after stroke: An updated systematic review and\n                    meta-analysis of observational studies","volume":"9","author":"M L Hackett","year":"2014","journal-title":"Int J Stroke"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1111\/j.1525-1497.2005.00269.x","article-title":"Prevalence of depression in survivors of acute myocardial infarction","volume":"21","author":"B D Thombs","year":"2006","journal-title":"J Gen Intern Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.psychres.2019.03.041","article-title":"A comparison of potential psychiatric drug interactions from six drug\n                    interaction database programs","volume":"275","author":"S Monteith","year":"2019","journal-title":"Psychiatry Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1177\/2042098618784809","article-title":"Using EMR-enabled computerized decision support systems to reduce prescribing of\n                    potentially inappropriate medications: A narrative review","volume":"9","author":"I A Scott","year":"2018","journal-title":"Ther Adv Drug Saf"},{"key":"ref25","first-page":"573","article-title":"Reasons provided by prescribers when overriding drug-drug interaction\n                    alerts","volume":"13","author":"A J Grizzle","year":"2007","journal-title":"Am J Manag Care"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.schres.2012.10.015","article-title":"Interventions to reduce antipsychotic polypharmacy: A systematic review","volume":"143","author":"H Tani","year":"2013","journal-title":"Schizophr Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/JGP.0b013e318172b42d","article-title":"Effects of age and age of onset on prescribed antipsychotic dose in\n                    schizophrenia spectrum disorders: A survey of 1,418 patients in Japan","volume":"16","author":"H Uchida","year":"2008","journal-title":"Am J Geriatr Psychiatry"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1055\/a-1156-4193","article-title":"Potential drug interactions with drugs used for bipolar disorder: A comparison\n                    of 6 drug interaction database programs","volume":"53","author":"S Monteith","year":"2020","journal-title":"Pharmacopsychiatry"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/j.2051-5545.2011.tb00014.x","article-title":"Physical illness in patients with severe mental disorders. I. Prevalence, impact\n                    of medications and disparities in health care","volume":"10","author":"M De Hert","year":"2011","journal-title":"World Psychiatry"}],"container-title":["Pharmacopsychiatry"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1744-6582.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T11:23:44Z","timestamp":1764069824000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1744-6582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,4]]},"references-count":24,"journal-issue":{"issue":"03","published-online":{"date-parts":[[2022,5,16]]},"published-print":{"date-parts":[[2022,5]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1744-6582","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0176-3679","1439-0795"],"issn-type":[{"value":"0176-3679","type":"print"},{"value":"1439-0795","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,2,4]]}}}