{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:39Z","timestamp":1740126819225,"version":"3.37.3"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background We aimed at evaluating acute neurologic complications (ANC) and\n                    clinical outcome at a 2-year follow-up in children after extracorporeal membrane\n                    oxygenation (ECMO).<\/jats:p><jats:p>\n          Methods We conducted a single-center, retrospective review of our patient\n                    cohort aged between 1 month and 18 years at the time of ECMO support (between\n                    June 2014 to January 2017). Outcome analysis included ANC and their clinical\n                    consequences.The Pediatric Overall Performance Category (POPC) and Pediatric\n                    Cerebral Performance Category (PCPC) were used for neurologic assessment\n                    performed at discharge from the hospital and at 2nd year follow-up.<\/jats:p><jats:p>\n          Results There were 35 children who required ECMO. The median ECMO time was\n                    9 days (range 2\u201332 days). Decannulation from ECMO was achieved in\n                    68.6% of patients, and overall, 42.8% survived (15 patients),\n                    The incidence of ANC in the surviving patients was 40% (6 children). ANC\n                    were intracranial hemorrhage, seizures, cerebral infarction, which occurred in\n                    one, two and three of the 15 surviving patients respectively (6.6, 13.3 and\n                    20%). A higher rate of organ failure was related to death\n                    (p=0.043), whereas duration on ECMO was a risk factor for the\n                    development of ANC (p&lt;0.05). At hospital discharge, the 14 patients\n                    evaluated had normal development or -mild disability in 73.2%, and at\n                    the 2-year follow-up, 93.4% had these scores.<\/jats:p><jats:p>\n          Conclusion Children who receive ECMO have a risk to develop ANC, which was\n                    related to the length of ECMO treatment, while survival was related to less\n                    organ failure, Long-term neurological outcome was good in our patient\n                    cohort.<\/jats:p>","DOI":"10.1055\/a-1749-6096","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:04:08Z","timestamp":1645488248000},"page":"96-104","source":"Crossref","is-referenced-by-count":1,"title":["Early Neurologic Complications and Long-term Neurologic Outcomes of\n                    Extracorporeal Membrane Oxygenation Performed in Children"],"prefix":"10.1055","volume":"234","author":[{"given":"Ebru","family":"Azapagasi","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care, Dr Sami Ulus Gynecology Obstetrics and Child\n                    Health and Diseases Training and Research Hospital, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tan\u0131l","family":"Kendirli","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care, Ankara University Faculty of Medicine,\n                    Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4027-6330","authenticated-orcid":false,"given":"Gokcen Oz","family":"Tun\u00e7er","sequence":"additional","affiliation":[{"name":"Pediatric Neurology , Ankara University Faculty of Medicine, Ankara,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oktay","family":"Perk","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care, Ankara University Faculty of Medicine,\n                    Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selen Yilmaz","family":"Isikhan","sequence":"additional","affiliation":[{"name":"Biostatistics, Hacettepe University Faculty of Medicine, Ankara,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serap Teber","family":"T\u0131ras","sequence":"additional","affiliation":[{"name":"Pediatric Neurology , Ankara University Faculty of Medicine, Ankara,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeynep","family":"Eyileten","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Surgery, Ankara University Faculty of Medicine,\n                    Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdal","family":"Ince","sequence":"additional","affiliation":[{"name":"Pediatric Intensive Care, Ankara University Faculty of Medicine,\n                    Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Uysalel","sequence":"additional","affiliation":[{"name":"Pediatric Cardiac Surgery, Ankara University Faculty of Medicine,\n                    Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmet R\u00fc\u00e7han","family":"Akar","sequence":"additional","affiliation":[{"name":"Cardiovascular Surgery, Ankara University Faculty of Medicine, Ankara,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"ref2","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1097\/MAT.0000000000000603","article-title":"Pediatric Extracorporeal Life Support Organization Registry International Report\n                    2016","volume":"63","author":"R P Barbaro","year":"2017","journal-title":"ASAIO journal (American Society for Artificial Internal Organs:\n                    1992)"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1097\/PCC.0b013e318198bd85","article-title":"Neurological injury after extracorporeal membrane oxygenation use to aid\n                    pediatric cardiopulmonary resuscitation","volume":"10","author":"C S Barrett","year":"2009","journal-title":"Pediatric critical care medicine: A journal of the Society of\n                    Critical Care Medicine and the World Federation of Pediatric Intensive and\n                    Critical Care Societies"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1016\/j.athoracsur.2018.12.027","article-title":"Acute Neurologic injury in children admitted to the cardiac intensive care\n                    unit","volume":"107","author":"J L Bell","year":"2019","journal-title":"The Annals of thoracic surgery"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1097\/PCC.0000000000000415","article-title":"Neuromonitoring during extracorporeal membrane oxygenation: A systematic review\n                    of the literature","volume":"16","author":"M M Bembea","year":"2015","journal-title":"Pediatric critical care medicine: Journal of the Society of Critical\n                    Care Medicine and the World Federation of Pediatric Intensive and Critical Care\n                    Societies"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/MAT.0000000000000933","article-title":"Neurologic outcomes in a two-center cohort of neonatal and pediatric patients\n                    supported on extracorporeal membrane oxygenation","volume":"66","author":"M M Bembea","year":"2020","journal-title":"ASAIO journal (American Society for Artificial Internal Organs:\n                    1992)"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1097\/CCM.0000000000001145","article-title":"Plasma biomarkers of brain injury as diagnostic tools and outcome predictors\n                    after extracorporeal membrane oxygenation","volume":"43","author":"M M Bembea","year":"2015","journal-title":"Critical care medicine"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1097\/PCC.0000000000001612","article-title":"Neurologic Outcomes After Extracorporeal Membrane Oxygenation: A Systematic\n                    Review","volume":"19","author":"K Boyle","year":"2018","journal-title":"Pediatric critical care medicine: A journal of the Society of\n                    Critical Care Medicine and the World Federation of Pediatric Intensive and\n                    Critical Care Societies"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s00383-018-4225-5","article-title":"Use of venovenous ECMO for neonatal and pediatric ECMO: a decade of experience\n                    at a tertiary children\u2019s hospital","volume":"34","author":"J L Carpenter","year":"2018","journal-title":"Pediatric surgery international"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1097\/01.CCM.0000189940.70617.C3","article-title":"Central nervous system complications during pediatric extracorporeal life\n                    support: incidence and risk factors","volume":"33","author":"P Cengiz","year":"2005","journal-title":"Critical care medicine"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3389\/fped.2013.00047","article-title":"Neurodevelopmental outcomes after pediatric cardiac ECMO Support","volume":"1","author":"C Chrysostomou","year":"2013","journal-title":"Frontiers in pediatrics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jtcvs.2012.11.014","article-title":"Short- and intermediate-term survival after extracorporeal membrane oxygenation\n                    in children with cardiac disease","volume":"146","author":"C Chrysostomou","year":"2013","journal-title":"The Journal of thoracic and cardiovascular surgery"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S0022-3476(05)82544-2","article-title":"Assessing the outcome of pediatric intensive care","volume":"121","author":"D H Fiser","year":"1992","journal-title":"The Journal of pediatrics"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"338","DOI":"10.3171\/2011.1.PEDS10443","article-title":"Neurological complications of extracorporeal membrane oxygenation in\n                    children","volume":"7","author":"S L Hervey-Jumper","year":"2011","journal-title":"Journal of neurosurgery Pediatrics"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.pediatrneurol.2017.05.006","article-title":"Patterns of head computed tomography abnormalities during pediatric\n                    extracorporeal membrane oxygenation and association with outcomes","volume":"73","author":"K L LaRovere","year":"2017","journal-title":"Pediatric neurology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1503\/cmaj.081715","article-title":"Daily estimation of the severity of multiple organ dysfunction syndrome in\n                    critically ill children","volume":"182","author":"S Leteurtre","year":"2010","journal-title":"CMAJ: Canadian Medical Association journal=journal de\n                    l\u2019Association medicale canadienne"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/S0140-6736(03)13908-6","article-title":"Validation of the paediatric logistic organ dysfunction (PELOD) score:\n                    prospective, observational, multicentre study","volume":"362","author":"S Leteurtre","year":"2003","journal-title":"Lancet (London, England)"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.acra.2006.10.004","article-title":"Cranial CT for diagnosis of intracranial complications in adult and pediatric\n                    patients during ECMO: Clinical benefits in diagnosis and treatment","volume":"14","author":"M K Lidegran","year":"2007","journal-title":"Academic radiology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/ams2.76","article-title":"Effects of the elective introduction of extracorporeal membrane oxygenation on\n                    outcomes in pediatric myocarditis cases","volume":"2","author":"N Nosaka","year":"2015","journal-title":"Acute medicine & surgery"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1097\/PCC.0000000000001730","article-title":"Prevalence of seizures in pediatric extracorporeal membrane oxygenation patients\n                    as measured by continuous electroencephalography","volume":"19","author":"S Okochi","year":"2018","journal-title":"Pediatric critical care medicine: Journal of the Society of Critical\n                    Care Medicine and the World Federation of Pediatric Intensive and Critical Care\n                    Societies"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/PCC.0b013e318291755a","article-title":"Nonconvulsive seizures are common in children treated with extracorporeal\n                    cardiac life support","volume":"14","author":"J A Piantino","year":"2013","journal-title":"Pediatric critical care medicine: Journal of the Society of Critical\n                    Care Medicine and the World Federation of Pediatric Intensive and Critical Care\n                    Societies"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1097\/00003246-199605000-00004","article-title":"PRISM III: an updated Pediatric Risk of Mortality score","volume":"24","author":"M M Pollack","year":"1996","journal-title":"Critical care medicine"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1097\/00003246-198811000-00006","article-title":"Pediatric risk of mortality (PRISM) score","volume":"16","author":"M M Pollack","year":"1988","journal-title":"Critical care medicine"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jpedsurg.2011.10.017","article-title":"Extracorporeal membrane oxygenation cannulation trends for pediatric respiratory\n                    failure and central nervous system injury","volume":"47","author":"M D Rollins","year":"2012","journal-title":"Journal of pediatric surgery"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2020.03.014","article-title":"Neurological Monitoring and Complications of Pediatric Extracorporeal Membrane\n                    Oxygenation Support","author":"A S Said","year":"2020","journal-title":"Pediatric neurology"}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1749-6096.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:46:22Z","timestamp":1646700382000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1749-6096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,21]]},"references-count":24,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2022,3,7]]},"published-print":{"date-parts":[[2022,3]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1749-6096","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"type":"print","value":"0300-8630"},{"type":"electronic","value":"1439-3824"}],"subject":[],"published":{"date-parts":[[2022,2,21]]}}}