{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T18:58:59Z","timestamp":1772305139434,"version":"3.50.1"},"reference-count":37,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hydrogen sulfide (H2S) is a toxic compound known as a member of the\n                    gasotransmitter family. H2S has the ability to inhibit the cytochrome\n                    c oxidase enzyme in the mitochondrial respiratory chain. Mitochondria play an\n                    important role in energy production and the brain needs energy for normal\n                    function. Mitochondrial dysfunction is associated with neurodegenerative\n                    diseases. This study investigated the mechanisms of cytotoxicity induced by\n                        H2S in brain neurons. thioacetamide has been used to produce\n                        H2S in water solutions. The results of the study showed that\n                    thioacetamide at concentrations of 116, 232 and\n                    464\u2009\u00b5g\/ml was able to increase the level of reactive\n                    oxygen species (ROS), collapse in mitochondrial membrane potential (MMP), damage\n                    to the lysosomal membrane, increase in the level of oxidized glutathione (GSSG)\n                    and decrease in the level of reduced glutathione (GSH) in brain neurons. The\n                    results of the study suggested that H2S causes damage to mitochondria\n                    and lysosomes in brain neurons that could be associated with neurodegenerative\n                    diseases.<\/jats:p>","DOI":"10.1055\/a-1750-8870","type":"journal-article","created":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T23:57:47Z","timestamp":1645142267000},"page":"197-202","source":"Crossref","is-referenced-by-count":14,"title":["Toxicity of Hydrogen Sulfide on Rat Brain Neurons"],"prefix":"10.1055","volume":"72","author":[{"given":"Enayatollah","family":"Seydi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Irandoost","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Pharmacology, School of Pharmacy, Shahid\n                    Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmoud Ghazi","family":"Khansari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Medicine, Tehran University of\n                    Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parvaneh","family":"Naserzadeh","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Pharmacology, School of Pharmacy, Shahid\n                    Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farahnaz","family":"Tanbakosazan","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Pharmacology, School of Pharmacy, Shahid\n                    Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jalal","family":"Pourahmad","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Pharmacology, School of Pharmacy, Shahid\n           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