{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:06:39Z","timestamp":1754107599342,"version":"3.37.3"},"reference-count":83,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Exp Clin Endocrinol Diabetes"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Non-mesenchymal pancreatic cells are a potential source for cell replacement.\n                    Their transdifferentiation can be achieved by triggering epigenetic remodeling\n                    through e.\u2009g. post-translational modification of histones. Valproic\n                    acid, a branched-chain saturated fatty acid with histone deacetylase inhibitor\n                    activity, was linked to the expression of key transcription factors of\n                    pancreatic lineage in epithelial cells and insulin transcription. However, the\n                    potential of valproic acid to cause cellular reprogramming is not fully\n                    understood. To shed further light on it we employed next-generation RNA\n                    sequencing, real-time PCR, and protein analyses by ELISA and western blot, to\n                    assess the impact of valproic acid on transcriptome and function of\n                    Panc-1-cells. Our results indicate that valproic acid has a significant impact\n                    on the cell cycle, cell adhesion, histone H3 acetylation, and metabolic pathways\n                    as well as the initiation of epithelial-mesenchymal transition through\n                    acetylation of histone H3 resulting in \u03b1-cell-like characteristics. We\n                    conclude that human epithelial pancreatic cells can be transdifferentiated into\n                    cells with endocrine properties through epigenetic regulation by valproic acid\n                    favoring an \u03b1-cell-like phenotype.<\/jats:p>","DOI":"10.1055\/a-1750-9190","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T00:48:27Z","timestamp":1650588507000},"page":"638-651","source":"Crossref","is-referenced-by-count":1,"title":["Valproic Acid Initiates Transdifferentiation of the Human Ductal\n                    Adenocarcinoma Cell-line Panc-1 Into \u03b1-Like Cells"],"prefix":"10.1055","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3496-9894","authenticated-orcid":false,"given":"Sebastian Friedrich","family":"Petry","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Center of Internal Medicine, Medical Clinic and\n                    Polyclinic III, Justus Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naga Deepa","family":"Kandula","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Center of Internal Medicine, Medical Clinic and\n                    Polyclinic III, Justus Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"G\u00fcnther","sequence":"additional","affiliation":[{"name":"Bioinformatics and deep sequencing platform, Max Planck Institute for\n                    Heart and Lung Research, Bad Nauheim, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Helker","sequence":"additional","affiliation":[{"name":"Cell Signaling and Dynamics, Department of Biology, Philipps\n                    University, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Undraga","family":"Schagdarsurengin","sequence":"additional","affiliation":[{"name":"Epigenetics of Urogenital System, Clinic and Polyclinic of Urology,\n                    Pediatric Urology and Andrology, Justus Liebig University, Giessen,\n                    Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Linn","sequence":"additional","affiliation":[{"name":"Clinical Research Unit, Center of Internal Medicine, Medical Clinic and\n                    Polyclinic III, Justus Liebig University, Giessen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,4,21]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1038\/nbt.3033","article-title":"Reversal of diabetes with insulin-producing cells derived in vitro from human\n                    pluripotent stem 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