{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:13:34Z","timestamp":1779185614742,"version":"3.51.4"},"reference-count":84,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Laryngorhinootologie"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund\u2002Die chronische Rhinosinusitis mit Nasenpolypen (CRSwNP) ist eine multifaktorielle entz\u00fcndliche Erkrankung der paranasalen Schleimh\u00e4ute, der als h\u00e4ufigstem Endotyp eine eosinophile Inflammation zugrunde liegt. Der Anti-IL-5-Antik\u00f6rper Mepolizumab wurde im November 2021 f\u00fcr die Therapie der schweren CRSwNP zugelassen.<\/jats:p><jats:p>\n          Methoden\u2002In einer Literatursuche wurde die Immunologie der CRSwNP analysiert und die vorhandene Evidenz ermittelt durch Recherchen in Medline, PubMed sowie den nationalen und internationalen Studien- und Leitlinien-Registern und der Cochrane Library. Es wurden Humanstudien ber\u00fccksichtigt, die bis einschlie\u00dflich 12\/2021 publiziert wurden und in denen die Wirkung von Mepolizumab bei CRSwNP untersucht wurde.<\/jats:p><jats:p>\n          Ergebnis\u2002Basierend auf der internationalen Literatur und bisherigen Erfahrungen werden von einem Expertengremium Empfehlungen f\u00fcr die Anwendung von Mepolizumab bei CRSwNP im deutschen Gesundheitssystem auf der Grundlage eines Dokumentationsbogens gegeben.<\/jats:p><jats:p>\n          Schlussfolgerungen\u2002Das Verst\u00e4ndnis \u00fcber die immunologischen Grundlagen der CRSwNP er\u00f6ffnet neue nichtoperative Therapieans\u00e4tze mit Biologika f\u00fcr Patienten mit schweren Verlaufsformen. Mepolizumab ist seit November 2021 zugelassen zur Zusatztherapie mit intranasalen Kortikosteroiden zur Behandlung von erwachsenen Patienten mit schwerer CRSwNP, die mit systemischen Kortikosteroiden und\/oder chirurgischem Eingriff nicht ausreichend kontrolliert werden k\u00f6nnen.<\/jats:p>","DOI":"10.1055\/a-1752-8462","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T00:35:37Z","timestamp":1644971737000},"page":"284-294","source":"Crossref","is-referenced-by-count":12,"title":["Positionspapier: Empfehlungen zur Anwendung von Mepolizumab bei chronischer Rhinosinusitis mit Polyposis nasi (CRSwNP) im deutschen Gesundheitssystem \u2013 Empfehlungen des \u00c4rzteverbandes Deutscher Allergologen (AeDA) und der AGs Klinische Immunologie, Allergologie und Umweltmedizin und Rhinologie und Rhinochirurgie der Deutschen Gesellschaft f\u00fcr HNO-Heilkunde, Kopf- und Hals-Chirurgie (DGHNO-KHC)"],"prefix":"10.1055","volume":"101","author":[{"given":"L.","family":"Klimek","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Rhinologie und Allergologie, Wiesbaden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Olze","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"F\u00f6rster-Ruhrmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-Nasen-Ohrenheilkunde, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Berlin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. 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K.","family":"Hoffmann","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Universit\u00e4tsklinikum Ulm"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Dazert","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Universit\u00e4tsklinikum Bochum"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Deitmer","sequence":"additional","affiliation":[{"name":"Deutsche Gesellschaft f\u00fcr Hals-, Nasen- und Ohrenheilkunde, Kopf- und Halschirurgie, Bonn"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Strieth","sequence":"additional","affiliation":[{"name":"Klinik u. 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