{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:40Z","timestamp":1740126820248,"version":"3.37.3"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"01","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Padiatr"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background While children are considered at low risk for COVID-19, little\n                    is known about the impact of SARS-CoV-2 on paediatric risk patients like\n                    children with Trisomy 21 (T21). As these children often need regular therapy and\n                    various medical appointments, this study aimed to investigate the possible\n                    impact of the COVID-19 pandemic on children with T21.<\/jats:p><jats:p>\n          Patients and Methods Parents of children with T21 in the age of\n                    0\u201312 years in Saxony-Anhalt were interviewed via phone in June 2021\n                    regarding the health status and medical care of their children during the past\n                    15 months of pandemic.<\/jats:p><jats:p>\n          Results 37 children with mean age of 6.1 years (min 0; max 12) were\n                    included in the study. The majority did not have any additional congenital\n                    anomalies. Surveyed parents hardly reported adverse changes of health status\n                    during the pandemic, but rather improvements, such as decreased number of\n                    respiratory infections and more time spend with their children. Outpatient\n                    appointments and therapy were cancelled or postponed at the onset of the\n                    pandemic, but parents reported low impact on their child\u2019s health and\n                    development. The main concern seemed to be lack of childcare during school and\n                    day-care closures and uncertainty concerning possible health impacts of an\n                    infection on their children.<\/jats:p><jats:p>\n          Conclusion There was low impact of the COVID-19 pandemic on health and\n                    medical care of children with T21 in our study population. Further research is\n                    needed to help weigh the child\u2019s individual risk of infection against\n                    the need for medical treatment and therapy when dealing with paediatric risk\n                    patients.<\/jats:p>","DOI":"10.1055\/a-1757-9948","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T22:44:03Z","timestamp":1663281843000},"page":"31-37","source":"Crossref","is-referenced-by-count":0,"title":["Impact of the COVID-19 Pandemic Regulations on the Health Status and\n                    Medical Care of Children with Trisomy 21"],"prefix":"10.1055","volume":"235","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4404-1053","authenticated-orcid":false,"given":"Annika","family":"Niemann","sequence":"additional","affiliation":[{"name":"Malformation Monitoring Centre Saxony-Anhalt, Otto von Guericke\n                    University Medical Faculty, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anett","family":"Boudriot","sequence":"additional","affiliation":[{"name":"Social Paediatric Centre, Children\u2019s Centre Magdeburg gGmbH,\n                    Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Brett","sequence":"additional","affiliation":[{"name":"Social Paediatric Centre, Children\u2019s Centre Magdeburg gGmbH,\n                    Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christiane","family":"Fritzsch","sequence":"additional","affiliation":[{"name":"Social Paediatric Centre, St. Elisabeth and St. Barbara Hospital Halle\n                    (Saale), Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorit","family":"G\u00f6tz","sequence":"additional","affiliation":[{"name":"Malformation Monitoring Centre Saxony-Anhalt, Otto von Guericke\n                    University Medical Faculty, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Haase","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinder- und Jugendmedizin,\n                    Martin-Luther-Universit\u00e4t Halle Wittenberg, Halle\/Saale,\n                    Germany"},{"name":"Department of Neonatology and Paediatric Intensive Care, St. Elisabeth\n                    and St. Barbara Hospital Halle (Saale), Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sibylle","family":"H\u00f6hne","sequence":"additional","affiliation":[{"name":"Social Paediatric Centre, St. Elisabeth and St. Barbara Hospital Halle\n                    (Saale), Halle (Saale), Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerhard","family":"Jorch","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Magdeburg,\n                    Universit\u00e4tskinderklinik, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"K\u00f6hn","sequence":"additional","affiliation":[{"name":"Malformation Monitoring Centre Saxony-Anhalt, Otto von Guericke\n                    University Medical Faculty, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Lux","sequence":"additional","affiliation":[{"name":"Institute of Biometry and Medical Informatics, Otto von Guericke\n                    University Medical Faculty, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Zenker","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Humangenetik, Otto von Guericke Universitat\n                    Magdeburg, Magdeburg, Germany"},{"name":"Department of Paediatrics, Otto von Guericke University Medical\n                    Faculty, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Rissmann","sequence":"additional","affiliation":[{"name":"Malformation Monitoring Centre Saxony-Anhalt, Otto von Guericke\n                    University Medical Faculty, Magdeburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,9,15]]},"reference":[{"key":"ref1","first-page":"407","article-title":"Down\u2019s syndrome and COVID-19: risk or protection factor against\n                    infection?","volume":"42","author":"M Altable","year":"2021","journal-title":"A molecular and genetic approach. Neurol Sci"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1055\/a-1247-5119","article-title":"Auswirkungen der SARS-CoV-2 Pandemie auf die\n                    Fr\u00fcherkennungs-Untersuchungen bei Kindern","volume":"233","author":"O Blankenstein","year":"2021","journal-title":"Klin Padiatr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1111\/apa.15409","article-title":"COVID-19 and Down syndrome","volume":"109","author":"M Callea","year":"2020","journal-title":"Acta Paediatr"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"572","DOI":"10.7326\/M20-4986","article-title":"COVID-19 Mortality Risk in Down Syndrome: Results From a Cohort Study of 8\n                    Million Adults","volume":"174","author":"A K Clift","year":"2021","journal-title":"Ann Intern Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e1008559","DOI":"10.1371\/journal.pcbi.1008559","article-title":"The role of children in the spread of COVID-19: Using household data from Bnei\n                    Brak, Israel, to estimate the relative susceptibility and infectivity of\n                    children","volume":"17","author":"I Dattner","year":"2021","journal-title":"PLoS Comput Biol"},{"key":"ref6","first-page":"18","article-title":"Impact of the COVID-19 Italian Lockdown on the Physiological and Psychological\n                    Well-Being of Children with Fragile X Syndrome and Their Families","author":"E Di Giorgio","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"ref7","first-page":"31","article-title":"Auswirkung des SARS-CoV2-Lockdowns auf die p\u00e4diatrische Versorgung im\n                    Rhein-Main-Gebiet","volume":"233","author":"H Donath","year":"2021","journal-title":"Klin Padiatr"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1080\/07853890.2021.1922743","article-title":"The reported effects of the COVID-19 pandemic on people with intellectual\n                    disability and their carers: a scoping review","volume":"53","author":"O Doody","year":"2021","journal-title":"Ann Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S2352-4642(20)30177-2","article-title":"COVID-19 in children and adolescents in Europe: a multinational, multicentre\n                    cohort study","volume":"4","author":"F G\u00f6tzinger","year":"2020","journal-title":"The Lancet Child & Adolescent Health"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jnn.2020.10.005","article-title":"The implications of face masks for babies and families during the COVID-19\n                    pandemic: A discussion paper","volume":"27","author":"J Green","year":"2021","journal-title":"J Neonatal Nurs"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1186\/s12887-020-02471-5","article-title":"COVID-19 and children with Down syndrome: is there any real reason to worry? Two\n                    case reports with severe course","volume":"20","author":"A Kantar","year":"2020","journal-title":"BMC Pediatr"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/jpids\/piaa148","article-title":"SARS-CoV-2 Triggering Severe Acute Respiratory Distress Syndrome and Secondary\n                    Hemophagocytic Lymphohistiocytosis in a 3-Year-Old Child With Down Syndrome","volume":"10","author":"S Kim-Hellmuth","year":"2021","journal-title":"J Pediatric Infect Dis Soc"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e049876","DOI":"10.1136\/bmjopen-2021-049876","article-title":"SARS-CoV-2 seroprevalence in students and teachers: a longitudinal study from\n                    May to October 2020 in German secondary schools","volume":"11","author":"C Kirsten","year":"2021","journal-title":"BMJ Open"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1055\/a-1341-9530","article-title":"Prevalence of COVID-19 Among Children and Adolescents While Easing Lockdown\n                    Restrictions in Cologne, North Rhine-Westphalia, Germany","volume":"233","author":"R W K\u00f6rner","year":"2021","journal-title":"Klin Padiatr"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.jpeds.2020.06.076","article-title":"SARS-CoV-2 Infection in Patients with Down Syndrome, Congenital Heart Disease,\n                    and Pulmonary Hypertension: Is Down Syndrome a Risk Factor?","volume":"225","author":"U S Krishnan","year":"2020","journal-title":"J Pediatr"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/ejhg.2012.94","article-title":"Twenty-year trends in the prevalence of Down syndrome and other trisomies in\n                    Europe: impact of maternal age and prenatal screening","volume":"21","author":"M Loane","year":"2013","journal-title":"Eur J Hum Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/apa.15270","article-title":"Systematic review of COVID-19 in children shows milder cases and a better\n                    prognosis than adults","volume":"109","author":"J F Ludvigsson","year":"2020","journal-title":"Acta Paediatr"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41436-020-01004-w","article-title":"Individuals with Down syndrome hospitalized with COVID-19 have more severe\n                    disease","volume":"23","author":"L Malle","year":"2021","journal-title":"Genet Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e13314","DOI":"10.1111\/jsr.13314","article-title":"Severe effects of the COVID-19 confinement on young children\u2019s sleep: A\n                    longitudinal study identifying risk and protective factors","volume":"30","author":"A Markovic","year":"2021","journal-title":"J Sleep Res"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1093\/cid\/ciaa556","article-title":"SARS-CoV-2 (COVID-19): What Do We Know About Children? A Systematic Review","volume":"71","author":"N S Mehta","year":"2020","journal-title":"Clin Infect Dis"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1002\/ajmg.a.36780","article-title":"Major congenital anomalies in babies born with Down syndrome: a EUROCAT\n                    population-based registry study","author":"J K Morris","year":"2014","journal-title":"Am J Med Genet A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.jpeds.2020.08.067","article-title":"Trisomy 21 and Coronavirus Disease 2019 in Pediatric Patients","volume":"228","author":"A M Newman","year":"2021","journal-title":"J Pediatr"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1186\/s12889-021-10257-2","article-title":"How did governmental interventions affect the spread of COVID-19 in European\n                    countries?","volume":"21","author":"RA J Post","year":"2021","journal-title":"BMC Public Health"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/ajmg.c.31876","article-title":"Transition to virtual clinic: Experience in a multidisciplinary clinic for Down\n                    syndrome","volume":"187","author":"S L Santoro","year":"2021","journal-title":"Am J Med Genet C Semin Med Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2964","DOI":"10.1002\/ajmg.a.61867","article-title":"Clinical characteristics of individuals with Down syndrome deceased with\n                    CoVID-19 in Italy \u2013 A case series","volume":"182","author":"E R Villani","year":"2020","journal-title":"Am J Med Genet A"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"578686","DOI":"10.3389\/fpsyt.2020.578686","article-title":"Impact of COVID-19-Related Lockdown on Psychosocial, Cognitive, and Functional\n                    Well-Being in Adults With Down Syndrome","volume":"11","author":"E R Villani","year":"2020","journal-title":"Front Psychiatry"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S2352-4642(20)30095-X","article-title":"School closure and management practices during coronavirus outbreaks including\n                    COVID-19: a rapid systematic review","volume":"4","author":"R M Viner","year":"2020","journal-title":"The Lancet Child & Adolescent Health"}],"container-title":["Klinische P\u00e4diatrie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1757-9948.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T12:46:37Z","timestamp":1734439597000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1757-9948"}},"subtitle":["A Parent Survey in Central Germany"],"short-title":[],"issued":{"date-parts":[[2022,9,15]]},"references-count":27,"journal-issue":{"issue":"01","published-online":{"date-parts":[[2023,1,5]]},"published-print":{"date-parts":[[2023,1]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1757-9948","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0300-8630","1439-3824"],"issn-type":[{"type":"print","value":"0300-8630"},{"type":"electronic","value":"1439-3824"}],"subject":[],"published":{"date-parts":[[2022,9,15]]}}}