{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:00:23Z","timestamp":1785344423019,"version":"3.55.0"},"reference-count":32,"publisher":"Georg Thieme Verlag KG","issue":"04","license":[{"start":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:00:00Z","timestamp":1649894400000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002The light blue crest observed in narrow band imaging endoscopy has high diagnostic accuracy for diagnosis of gastric intestinal metaplasia (GIM). The objective of this prospective study was to evaluate the diagnostic accuracy of magnifying i-scan optical enhancement (OE) imaging for diagnosing the LBC sign in patients with different levels of risk for gastric cancer in a Mexican clinical practice.<\/jats:p><jats:p>\n          Patients and methods\u2002Patients with a history of peptic ulcer and symptoms of dyspepsia or gastroesophageal reflux disease were enrolled. Diagnosis of GIM was made at the predetermined anatomical location and white light endoscopy and i-scan OE Mode 1 were captured at the two predetermined biopsy sites (antrum and pyloric regions).<\/jats:p><jats:p>\n          Results\u2002A total of 328 patients were enrolled in this study. Overall GIM prevalence was 33.8\u200a%. The GIM distribution was 95.4\u200a% in the antrum and 40.5\u200a% in the corpus. According to the Operative Link on Gastritis\/Intestinal-Metaplasia Assessment staging system, only two patients (1.9\u200a%) were classified with high-risk stage disease. Sensitivity, specificity, positive\u200b and negative predictive values, positive and negative likelihood ratios, and accuracy of both methods (95\u200a% C.\u200aI.) were 0.50 (0.41\u20130.60), 0.55 (0.48\u20130.62), 0.36 (0.31\u20130.42), 0.68 (0.63\u20130.73), 1.12 (0.9\u20131.4), 0.9 (0.7\u20131.1), and 0.53 (0.43\u20130.60) for WLE, and 0.96 (0.90\u20130.99), 0.91 (0.86\u20130.94), 0.84 (0.78\u20130.89), 0.98 (0.94\u20130.99), 10.4 (6.8\u201316), 0.05 (0.02\u20130.12), and 0.93 (0.89\u20130.95), respectively. The kappa concordance was 0.67 and the reliability coefficient was 0.7407 for interobserver variability.<\/jats:p><jats:p>\n          Conclusions\u2002Our study demonstrated the high performance of magnifying i-scan OE imaging for endoscopic diagnosis of GIM in Mexican patients.<\/jats:p>","DOI":"10.1055\/a-1759-2568","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T22:30:20Z","timestamp":1649975420000},"page":"E441-E447","source":"Crossref","is-referenced-by-count":9,"title":["Usefulness of optical enhancement endoscopy combined with magnification to improve detection of intestinal metaplasia in the stomach"],"prefix":"10.1055","volume":"10","author":[{"given":"Sergio","family":"Sobrino-Coss\u00edo","sequence":"additional","affiliation":[{"name":"Hospital \u00c1ngeles del Pedregal, Ciudad de Mexico, Mexico"},{"name":"G\u00e1strica, Centro Avanzado en Endoscopia y Estudios Funcionales, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Teramoto-Matsubara","sequence":"additional","affiliation":[{"name":"G\u00e1strica, Centro Avanzado en Endoscopia y Estudios Funcionales, Mexico City, Mexico"},{"name":"Hospital ABC Ciudad de Mexico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Emura","sequence":"additional","affiliation":[{"name":"Endoscopia Gastrointestinal Avanzada, EmuraCenter Latinoam\u00e9rica y Departamento de Gastroenterolog\u00eda de la Universidad de la Sabana, Bogot\u00e1, Colombia"},{"name":"Departamento de Gastroenterolog\u00eda de la Universidad de la Sabana, Chia, Cundinamarca, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"Araya","sequence":"additional","affiliation":[{"name":"Servicio de Endoscopia y Gastroenterolog\u00eda de la Cl\u00ednica Universidad de Los Andes y del Hospital Militar de Santiago y Cl\u00ednica Universidad de los Andes, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00edtor","family":"Arantes","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas, Faculdade de Medicina, Universidade Federal de Minas Gerais, Hospital Mater Dei Contorno, Belo Horizonte, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elymir S.","family":"Galvis-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Department of Endoscopy. Hospital General de Mexico \u201cDr. Eduardo Liceaga,\u201d Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisi","family":"Meza-Caballero","sequence":"additional","affiliation":[{"name":"G\u00e1strica, Centro Avanzado en Endoscopia y Estudios Funcionales, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca Sinahi","family":"Garc\u00eda-Aguilar","sequence":"additional","affiliation":[{"name":"G\u00e1strica, Centro Avanzado en Endoscopia y Estudios Funcionales, Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Reding-Bernal","sequence":"additional","affiliation":[{"name":"Research Division, Hospital General de Mexico \u201cDr. Eduardo Liceaga,\u201d Mexico City, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriya","family":"Uedo","sequence":"additional","affiliation":[{"name":"Osaka International Cancer Institute, Department of Gastrointestinal Oncology, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,4,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1751-2980.2011.00550.x","article-title":"The gastric precancerous cascade","volume":"13","author":"P Correa","year":"2012","journal-title":"J Dig Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1046\/j.1365-2036.2002.01300.x","article-title":"Review article: intestinal metaplasia and gastric carcinogenesis","volume":"16","author":"W K Leung","year":"2002","journal-title":"Aliment Pharmacol Ther"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1055\/s-0031-1291491","article-title":"Management of precancerous conditions and lesions in the stomach (MAPS): guideline from the European Society of Gastrointestinal Endoscopy (ESGE), European Helicobacter Study Group (EHSG), European Society of Pathology (ESP), and the Sociedade Portuguesa de Endoscopia Digestiva (SPED)","volume":"44","author":"M Dinis-Ribeiro","year":"2012","journal-title":"Endoscopy"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/nrgastro.2015.128","article-title":"Optimizing early upper gastrointestinal cancer detection at endoscopy","volume":"12","author":"A M Veitch","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1055\/s-2006-944632","article-title":"A new method of diagnosing gastric intestinal metaplasia: narrow\u2212band imaging with magnifying endoscopy","volume":"38","author":"N Uedo","year":"2006","journal-title":"Endoscopy"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1186\/1471-230X-12-169","article-title":"Marginal turbid band and light blue crest, signs observed in magnifying narrow-band imaging endoscopy, are indicative of gastric intestinal metaplasia","volume":"12","author":"J K An","year":"2012","journal-title":"BMC Gastroenterol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1055\/s-0042-108435","article-title":"A multicenter prospective study of the real-time use of narrow-band imaging in the diagnosis of premalignant gastric conditions and lesions","volume":"48","author":"P Pimentel-Nunes","year":"2016","journal-title":"Endoscopy"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e92874","DOI":"10.1371\/journal.pone.0092874","article-title":"Diagnostic yield of the light blue crest sign in gastric intestinal metaplasia: a meta-analysis","volume":"9","author":"L Wang","year":"2014","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/den.12190","article-title":"Present and future perspectives of virtual chromoendoscopy with i-scan and optical enhancement technology","volume":"26","author":"H Neumann","year":"2014","journal-title":"Digest Endosc"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.dld.2013.10.005","article-title":"I-SCAN targeted versus random biopsies in Barrett's oesophagus","volume":"46","author":"C Verna","year":"2014","journal-title":"Dig Liver Dis"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.rgmx.2017.08.005","article-title":"Efficacy of narrow-band imaging for detecting intestinal metaplasia in adult patients with symptoms of dyspepsia","volume":"83","author":"S Sobrino-Coss\u00edo","year":"2018","journal-title":"Rev Gastroenterol M\u00e9x"},{"key":"ref12","first-page":"1161","article-title":"Classification and grading of gastritis. 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