{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T20:08:29Z","timestamp":1768680509663,"version":"3.49.0"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Priority Academic\n                        Program Development of Jiangsu Higher Education Institutions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Zinc-\u03b12-glycoprotein (ZAG) is an adipokine involved in body metabolism,\n                    and now it has been shown to be present in the brain and play a role in some\n                    neurological diseases such as epilepsy and Alzheimer\u2019s disease. In the\n                    present study, we employed ZAG knockout (KO) mice to investigate the effects of\n                    ZAG on behaviors after fasting and in vitro used overexpression (OV) ZAG in\n                    HT-22 cells to further clarify the possibly underlying mechanism. The results\n                    showed that ZAG exists widely in the brain tissues of mice and significantly\n                    increased during fasting. In ZAG KO group the depression-like behaviors were\n                    significantly increased after fasting for 24\u2009hours, meanwhile the\n                    hippocampal reactive oxygen species (ROS) content was significantly increased.\n                    In vitro, serum deprivation led to the increasing of neuronal death and ROS, the\n                    reduced mitochondrial membrane potential and ATP levels, while ZAG\n                    overexpression alleviated these negative effects. The \u03b23 adrenoreceptor\n                    (\u03b23AR)\/protein kinase A (PKA)\/cAMP response\n                    element-binding (CREB) pathway possibly mediated the effects of ZAG on\n                    antioxidation. These results proposed a possible target for novel therapeutic\n                    approaches to the treatment of depression and provide potential link between\n                    adipose tissue and psychiatric disease.<\/jats:p>","DOI":"10.1055\/a-1759-3554","type":"journal-article","created":{"date-parts":[[2022,3,8]],"date-time":"2022-03-08T00:13:23Z","timestamp":1646698403000},"page":"259-267","source":"Crossref","is-referenced-by-count":4,"title":["Adipokine ZAG Alters Depression-Like Behavior by Regulating Oxidative\n                    Stress in Hippocampus"],"prefix":"10.1055","volume":"54","author":[{"given":"Huangbing","family":"Sun","sequence":"additional","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food\n                    Safety, Nanjing Agricultural University, Nanjing, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuli","family":"Ma","sequence":"additional","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food\n                    Safety, Nanjing Agricultural University, Nanjing, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Chen","sequence":"additional","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food\n                    Safety, Nanjing Agricultural University, Nanjing, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaojing","family":"Yang","sequence":"additional","affiliation":[{"name":"MOE Joint International Research Laboratory of Animal Health and Food\n                    Safety, Nanjing Agricultural University, Nanjing, P. R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"ref1","first-page":"13","article-title":"Secret talk between adipose tissue and central nervous system via secreted\n                    factors \u2013 an emerging frontier in the neurodegenerative research","author":"A Parimisetty","year":"2016","journal-title":"J Neuroinflam"},{"key":"ref2","first-page":"20","article-title":"The novel perspectives of adipokines on brain health","author":"T H Lee","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref3","first-page":"748048","article-title":"The role of adipokines in understanding the associations between obesity and\n                    depression","author":"V H Taylor","year":"2010","journal-title":"J Obes"},{"key":"ref4","first-page":"123","article-title":"Adipokine zinc-\u03b12-glycoprotein\n                    alleviates lipopolysaccharide-induced inflammatory responses through the\n 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