{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:45:54Z","timestamp":1757706354361},"reference-count":26,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose To evaluate the 2-year surgical treatment outcome in glaucoma patients.<\/jats:p><jats:p>\n          Methods A retrospective, single-center, interventional study was performed on 160 eyes of 125 patients suffering glaucoma, including POAG (82 eyes), pseudoexfoliation (PEX)\n\t\t\t\t\t(59\u00a0eyes), pigment dispersion (8 eyes), and secondary glaucoma (2 eyes). Eyes with uncontrolled intraocular pressure (IOP) or signs of glaucoma progression despite medical treatment were\n\t\t\t\t\tincluded to undergo either trabeculectomy (TE), XEN implantation, combined TE with phacoemulsification (TE + IOL), or XEN implantation with phacoemulsification surgery (XEN + IOL). Primary\n\t\t\t\t\tefficacy outcome was the mean IOP reduction. Secondary outcome was the mean reduction in the number of medications. The data were compared at baseline vs.1 day, 1 week, and 1, 3, 6, 12, and\n\t\t\t\t\t24 months following surgery. For statistical evaluation, ANOVA-based linear mixed-effects models were performed with SPSS.<\/jats:p><jats:p>\n          Results The mean IOP reduction in a 2-year follow-up was 30.31% (22.17 vs. 15.45\u2009mmHg, p\u2009&lt;\u20090.001). The mean number of antiglaucoma medications was reduced from 2.87 to 0.58\n\t\t\t\t\t(p\u2009=\u20090.001), where TE alone or combined surgeries seemed to be more effective than isolated XEN surgery. Transient IOP hypotony on the first postoperative day occurred in PEX patients\n\t\t\t\t\tfollowing TE surgery (p\u2009=\u20090.024). At 6 months, PEX patients with isolated XEN surgery showed a transient IOP increase, whereas those after combined TE + IOL surgery showed the lowest IOP\n\t\t\t\t\twithin the PEX group compared to other glaucoma patients (p\u2009&lt;\u20090.026).<\/jats:p><jats:p>\n          Conclusions After 2 years, all performed glaucoma surgeries achieved a significant reduction in IOP and the number of antiglaucoma medications.<\/jats:p>","DOI":"10.1055\/a-1766-7320","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T23:56:03Z","timestamp":1648079763000},"page":"435-442","source":"Crossref","is-referenced-by-count":3,"title":["Two-Year Outcome of Surgery in Glaucoma Patients"],"prefix":"10.1055","volume":"239","author":[{"given":"Roger","family":"H\u00fcppi","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cantonal Hospital St.\u00a0Gallen, St.\u00a0Gallen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Wagels","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cantonal Hospital St.\u00a0Gallen, St.\u00a0Gallen, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita","family":"Todorova","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, Cantonal Hospital St.\u00a0Gallen, St.\u00a0Gallen, Switzerland"},{"name":"Department of Ophthalmology, University of Basel, Basel, Switzerland"},{"name":"University of Z\u00fcrich, Z\u00fcrich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,3,23]]},"reference":[{"key":"ref1","first-page":"61","article-title":"Global data on visual impairment in the year 2002","volume":"17","author":"S Resnikoff","year":"2004","journal-title":"Community Eye Health"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Y C Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1016\/S0161-6420(01)00873-9","article-title":"CIGTS Study Group Interim clinical outcomes in the Collaborative Initial Glaucoma Treatment Study comparing initial treatment randomized to medications or surgery","volume":"108","author":"P R Lichter","year":"2001","journal-title":"Ophthalmology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"06","DOI":"10.1097\/00055735-200304000-00010","article-title":"Collaborative Initial Glaucoma Treatment Study. Collaborative Initial Glaucoma Treatment Study: A summary of results to date","volume":"14","author":"L Feiner","year":"2003","journal-title":"Curr Opin Ophthalmol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s00417-019-04251-z","article-title":"Two-year results of a multicenter study of the ab interno gelatin implant in medically uncontrolled primary open-angle glaucoma","volume":"257","author":"H Reitsamer","year":"2019","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"4789","DOI":"10.1167\/iovs.15-16625","article-title":"Fluid Dynamics of a Novel Micro-Fistula Implant for the Surgical Treatment of Glaucoma","volume":"56","author":"A Sheybani","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/ICU.0b013e3283360b68","article-title":"Tube Versus Trabeculectomy Study Group: Review of results from the Tube Versus Trabeculectomy Study","volume":"21","author":"S J Gedde","year":"2010","journal-title":"Curr Opin Ophthalmol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1080\/08820538.2021.1903513","article-title":"Microinvasive Glaucoma Surgery: An Evidence-Based Review","volume":"36","author":"F A Birnbaum","year":"2021","journal-title":"Semin Ophthalmol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s40662-019-0162-1","article-title":"Ab externo implantation of the MicroShunt, a poly (styrene-block-isobutylene-block-styrene) surgical device for the treatment of primary open-angle glaucoma: a review","volume":"6","author":"O Sadruddin","year":"2019","journal-title":"Eye Vis (Lond)"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s40123-016-0054-6","article-title":"The New Era of Glaucoma Micro-stent Surgery","volume":"5","author":"D T Manasses","year":"2016","journal-title":"Ophthalmol Ther"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/APO.0000000000000260","article-title":"Which Patients Would Most Likely to Benefit: MIGS or MEGS, Which One Is It?","volume":"8","author":"H Sheheitli","year":"2019","journal-title":"Asia Pac J Ophthalmol (Phila)"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ajo.2017.07.023","article-title":"Performance and safety of a new ab interno gelatin stent in refractory glaucoma at 12 months","volume":"183","author":"D S Grover","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e0256362","DOI":"10.1371\/journal.pone.0256362","article-title":"24-month outcomes of XEN45 gel implant versus trabeculectomy in primary glaucoma","volume":"16","author":"B Wanichwecharungruang","year":"2021","journal-title":"PLoS One"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ogla.2021.05.009","article-title":"Surgeon Experience as a Risk Factor for Short-Term Failure for Ab Interno Gelatin Microstent: A Canadian Multicenter Propensity-Matched Study","volume":"5","author":"M B Schlenker","year":"2022","journal-title":"Ophthalmol Glaucoma"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/ceo.13463","article-title":"Four-year results of a minimally invasive transscleral glaucoma gel stent implantation in a prospective multi-centre study","volume":"47","author":"M Lenzhofer","year":"2019","journal-title":"Clin Exp Ophthalmol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1177\/1120672120952033","article-title":"XEN 63 gel stent device in glaucoma surgery: A 5-years follow-up prospective study","volume":"31","author":"C Lavin-Dapena","year":"2021","journal-title":"Eur J Ophthalmol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/aos.14627","article-title":"Two-year outcomes of minimally invasive XEN Gel Stent implantation in primary open-angle and pseudoexfoliation glaucoma","volume":"99","author":"T Rauchegger","year":"2021","journal-title":"Acta Ophthalmol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1186\/s12886-020-01764-8","article-title":"Outcome of a single XEN microstent implant for glaucoma patients with different types of glaucoma","volume":"20","author":"M Schargus","year":"2020","journal-title":"BMC Ophthalmol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ajo.2011.01.032","article-title":"Risk factors for primary open-angle glaucoma and pseudoexfoliative glaucoma in the Thessaloniki eye study","volume":"152","author":"F Topouzis","year":"2011","journal-title":"Am J Ophthalmol"},{"key":"ref20","first-page":"944","article-title":"[New pathogenetic insights into pseudoexfoliation syndrome\/glaucoma. Therapeutically relevant?]","volume":"109","author":"U Schl\u00f6tzer-Schrehardt","year":"2012","journal-title":"Ophthalmologe"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1902","DOI":"10.1016\/S0161-6420(02)01267-8","article-title":"Surgical strategies for coexisting glaucoma and cataract: an evidence-based update","volume":"109","author":"D S Friedman","year":"2002","journal-title":"Ophthalmology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"6682534","DOI":"10.1155\/2021\/6682534","article-title":"Comparative Efficacy of Phacotrabeculectomy versus Trabeculectomy with or without Later Phacoemulsification: A Systematic Review with Meta-Analyses","volume":"2021","author":"A Ahmadzadeh","year":"2021","journal-title":"J Ophthalmol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1097\/IJG.0000000000000803","article-title":"Ab interno gel implant for the treatment of glaucoma patients with or without prior glaucoma surgery: 1-year results","volume":"26","author":"F H Hengerer","year":"2017","journal-title":"J Glaucoma"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1038\/eye.2017.162","article-title":"One-year result of XEN45 implant for glaucoma: efficacy, safety, and postoperative management","volume":"32","author":"S Z Tan","year":"2018","journal-title":"Eye (Lond)"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1177\/1120672118795063","article-title":"One-year follow-up of the XEN\u00ae implant with mitomycin-C in pseudoexfoliative glaucoma patients","volume":"29","author":"A Ib\u00e1\u00f1ez-Mu\u00f1oz","year":"2019","journal-title":"Eur J Ophthalmol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/j.ophtha.2017.05.004","article-title":"Efficacy, Safety, and Risk Factors for Failure of Standalone Ab Interno Gelatin Microstent Implantation versus Standalone Trabeculectomy","volume":"124","author":"M B Schlenker","year":"2017","journal-title":"Ophthalmology"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1766-7320.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T22:55:27Z","timestamp":1651013727000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1766-7320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,23]]},"references-count":26,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2022,4,26]]},"published-print":{"date-parts":[[2022,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1766-7320","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"value":"0023-2165","type":"print"},{"value":"1439-3999","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,23]]}}}