{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T03:01:31Z","timestamp":1774926091200,"version":"3.50.1"},"reference-count":44,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Geburtshilfe Frauenheilkd"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Introduction Awareness of SARS-CoV-2 infection in pregnant women and the potential risk for infection of their neonates is increasing. The aim of this study was to examine the immune\n\t\t\t\t\tstatus of affected women and evaluate the dynamics of placental antibody transfer.<\/jats:p><jats:p>\n          Materials and Methods The study included 176 women with SARS-CoV-2 infection during pregnancy who delivered between April 2020 and December 2021 at eight obstetric maternity sites.\n\t\t\t\t\tDemographic data, maternal and neonatal characteristics were summarized. Antibody testing for IgA and IgG in maternal blood sera and umbilical cord samples was evaluated and IgG transfer\n\t\t\t\t\tratios were calculated. Values were related to the time of infection during pregnancy and birth.<\/jats:p><jats:p>\n          Results The percentage of IgG positive women increased from 29.0% (95% CI 23.8\u200a\u2013\u200a37.8) at presentation with a positive PCR test result to 75.7% (95% CI 71.6\u200a\u2013\u200a79.8), the percentage\n\t\t\t\t\tof IgG positive umbilical cord blood samples increased from 17.1% (95% CI 13.0\u200a\u2013\u200a21.3) to 76.4% (95% CI 72.2\u200a\u2013\u200a80.7) at more than six weeks after infection. Regression lines differed\n\t\t\t\t\tsignificantly between maternal and fetal IgG responses (p\u2009&lt;\u20090.0001). Newborns react with a latency of about one week; umbilical cord blood antibody concentrations are highly correlated\n\t\t\t\t\twith maternal concentration levels (\u03c1\u2009=\u20090.8042; p\u2009&lt;\u20090.0001). IgG transplacental transfer ratios were dependent on infection-to-birth interval. Two of the umbilical cord blood samples\n\t\t\t\t\ttested positive for IgA.<\/jats:p><jats:p>\n          Conclusions These findings confirm vertical SARS-CoV-2 transmission is rare; however, antibodies are transferred to the fetus soon after infection during pregnancy. Since\n\t\t\t\t\ttransplacental antibody transfer might have a protective value for neonatal immunization this information may be helpful when counseling affected women.<\/jats:p>","DOI":"10.1055\/a-1768-0415","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T22:48:04Z","timestamp":1651877284000},"page":"501-509","source":"Crossref","is-referenced-by-count":14,"title":["Antibody Response and Maternofetal Antibody Transfer in SARS-CoV-2-Positive Pregnant Women: A Multicenter Observational Study"],"prefix":"10.1055","volume":"82","author":[{"given":"Sabine","family":"Enengl","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics, and Gynecological Endocrinology, Kepler University Hospital, Johannes Kepler University Linz, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Pecks","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Schleswig-Holstein University Hospital, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Oppelt","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics, and Gynecological Endocrinology, Kepler University Hospital, Johannes Kepler University Linz, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrick","family":"Stelzl","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics, and Gynecological Endocrinology, Kepler University Hospital, Johannes Kepler University Linz, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip Sebastian","family":"Trautner","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics, and Gynecological Endocrinology, Kepler University Hospital, Johannes Kepler University Linz, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Shebl","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics, and Gynecological Endocrinology, Kepler University Hospital, Johannes Kepler University Linz, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernd","family":"Lamprecht","sequence":"additional","affiliation":[{"name":"Department of Pulmonology, Kepler University Hospital, Johannes Kepler University Linz, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann Carolin","family":"Longardt","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Schleswig-Holstein University Hospital, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christel","family":"Eckmann-Scholz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Schleswig-Holstein University Hospital, Kiel, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corinna","family":"Keil","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Philipps University of Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadine","family":"Mand","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Philipps University of Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Constantin Sylvius","family":"von Kaisenberg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Hannover Medical School, Hannover, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Jegen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Hospital, LMU, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Doppler","sequence":"additional","affiliation":[{"name":"Department of Pathology, Kepler University Hospital, Johannes Kepler University Linz, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Lastinger","sequence":"additional","affiliation":[{"name":"Department of Gynecology, Obstetrics, and Gynecological Endocrinology, Kepler University Hospital, Johannes Kepler University Linz, Linz, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e13339","DOI":"10.1111\/aji.13339","article-title":"COVID-19-related disease severity in pregnancy","volume":"84","author":"J L Thompson","year":"2020","journal-title":"Am J Reprod 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