{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:13Z","timestamp":1740126793624,"version":"3.37.3"},"reference-count":9,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Zusammenfassung\u2002Physiologische Erh\u00f6hungen der Kreatinin-Kinase nach k\u00f6rperlicher Bet\u00e4tigung sind h\u00e4ufig und ein sinnvoller Cut-off-Wert besteht dabei nicht. Die Stufendiagnostik bei einer seltenen Ursache hierf\u00fcr und nach Auftreten einer Rhabdomyolyse wird in dieser Arbeit dargestellt.<\/jats:p><jats:p>\n          Anamnese\u2002Ein 36-j\u00e4hriger Soldat entwickelte nach starker k\u00f6rperlicher Belastung ein akutes Nierenversagen aufgrund einer Rhabdomyolyse.<\/jats:p><jats:p>\n          Untersuchung und Diagnostik\u2002Sportlicher Habitus, CK-Elevation bei hochnormalen Retentionswerten. Nach Stufenbelastung auf dem Fahrradergometer massiver CK-Anstieg. Anschlie\u00dfend Sportkarenz und Einleitung einer Stufendiagnostik.<\/jats:p><jats:p>\n          Therapie und Verlauf\u2002Die humangenetische Diagnostik konnte eine erbliche Myopathie des Fettstoffwechsels (VLCAD-Mangel) nachweisen. Eine individualisierte Leistungsdiagnostik ist zur Ermittlung der sicheren Belastungsgrenze herangezogen worden. In der sportlichen Erprobung dieser Leistungsgrenzen konnte keine \u00fcberm\u00e4\u00dfige CK-Aktivierung festgestellt werden.<\/jats:p><jats:p>\n          Folgerung\u2002Die hier bestehende sp\u00e4t auftretende Variante des VLCAD-Mangels ist durch rezidivierende Rhabdomyolysen gekennzeichnet, welche nach starker k\u00f6rperlicher Belastung, Fastenperioden oder Dehydratation auftreten k\u00f6nnen. Die k\u00f6rperliche Belastung kann nach Bestimmung der individuellen Toleranz fortgesetzt werden.<\/jats:p>","DOI":"10.1055\/a-1769-9073","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T22:30:26Z","timestamp":1649716226000},"page":"481-484","source":"Crossref","is-referenced-by-count":0,"title":["Sportmedizinische Beratung nach akuter Rhabdomyolyse bei erblicher Myopathie \u2013 eine herausfordernde Leistungsdiagnostik"],"prefix":"10.1055","volume":"147","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-0283","authenticated-orcid":false,"given":"Philipp Georg","family":"Schnadthorst","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Sportmedizin der Bundeswehr, Warendorf"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Schulze","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Sportmedizin der Bundeswehr, Warendorf"},{"name":"Orthop\u00e4dische Klinik und Poliklinik, Universit\u00e4tsmedizin Rostock"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Grunwald","sequence":"additional","affiliation":[{"name":"Zentrum f\u00fcr Sportmedizin der Bundeswehr, Warendorf"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,4,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"e000151","DOI":"10.1136\/bmjsem-2016-000151","article-title":"Exertional rhabdomyolysis: physiological response or manifestation of an underlying myopathy?","volume":"2","author":"R S Scalco","year":"2016","journal-title":"BMJ Open Sport Exerc Med"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1922\/ai2020.302","article-title":"Rhabdomyolyse. 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