{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T22:07:11Z","timestamp":1773094031936,"version":"3.50.1"},"reference-count":49,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["RE3146\/1-1"],"award-info":[{"award-number":["RE3146\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["GE2254\/1-1"],"award-info":[{"award-number":["GE2254\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Thromb Haemost"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and Aims\u2003The study aimed to assess the potential of proteoglycans (PGs) and collagens as serological biomarkers in the abdominal aortic aneurysm (AAA). Furthermore, we investigated the underlying mechano-biological interactions and signaling pathways.<\/jats:p><jats:p>\n          Methods\u2003Tissue and serum samples from patients with ruptured AAA (rAAA; n\u2009=\u200929), elective AAA (eAAA; n\u2009=\u200978), and healthy individuals (n\u2009=\u20098) were evaluated by histology, immunohistochemistry, and enzyme-linked immunosorbent assay, and mechanical properties were assessed by tensile tests. Regulatory pathways were determined by membrane-based sandwich immunoassay.<\/jats:p><jats:p>\n          Results\u2003In AAA samples, collagen type I and III (Col1 and Col3), chondroitin sulfate, and dermatan sulfate (DS) were significantly increased compared with controls (3.0-, 3.2-, 1.3-, and 53-fold; p\u2009&lt;\u20090.01). Col1 and endocan were also elevated in the serum of AAA patients (3.6- and 6.0-fold; p\u2009&lt;\u20090.01), while DS was significantly decreased (2.5-fold; p\u2009&lt;\u20090.01). Histological scoring showed increased total PGs and focal accumulation in rAAA compared with eAAA. Tissue \u03b2-stiffness was higher in rAAA compared with eAAA (2.0-fold, p\u2009=\u20090.02). Serum Col1 correlated with maximum tensile force and failure tension (r\u2009=\u20090.448 and 0.333; p\u2009&lt;\u20090.01, and r\u2009=\u20090.02), tissue endocan correlated with \u03b1-stiffness (r\u2009=\u20090.340; p\u2009&lt;\u20090.01). Signaling pathways in AAA were associated with extracellular matrix synthesis and vascular smooth muscle cell proliferation. In particular, Src family kinases and platelet-derived growth factor- and epidermal growth factor-related proteins seem to be involved.<\/jats:p><jats:p>\n          Conclusion\u2003Our findings reveal a structural association between collagen and PGs and their response to changes in mechanical loads in AAA. Particularly Col1 and endocan reflect the mechano-biological conditions of the aortic wall also in the patient's serum and might serve for AAA risk stratification.<\/jats:p>","DOI":"10.1055\/a-1772-0574","type":"journal-article","created":{"date-parts":[[2022,2,16]],"date-time":"2022-02-16T01:33:31Z","timestamp":1644975211000},"page":"1513-1523","source":"Crossref","is-referenced-by-count":3,"title":["Changes in Endocan and Dermatan Sulfate Are Associated with Biomechanical Properties of Abdominal Aortic Wall during Aneurysm Expansion and Rupture"],"prefix":"10.1055","volume":"122","author":[{"given":"Susanne","family":"Metschl","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lukas","family":"Bruder","sequence":"additional","affiliation":[{"name":"Mechanics and High Performance Computing Group, Technical University of Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5778-8981","authenticated-orcid":false,"given":"Valentina","family":"Paloschi","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Jakob","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benedikt","family":"Reutersberg","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"},{"name":"Department of Vascular Surgery, University Hospital Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Reeps","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic, and Vascular Surgery, Medizinische Fakult\u00e4t an der TU-Dresden, Dresden, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Maegdefessel","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Gee","sequence":"additional","affiliation":[{"name":"Mechanics and High Performance Computing Group, Technical University of Munich, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans-Henning","family":"Eckstein","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"},{"name":"German Center for Cardiovascular Research (DZHK), Partner Site Munich Heart Alliance, Munich, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8951-132X","authenticated-orcid":false,"given":"Jaroslav","family":"Pelisek","sequence":"additional","affiliation":[{"name":"Department of Vascular and Endovascular Surgery, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany"},{"name":"German Center for 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