{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T20:55:39Z","timestamp":1740171339062,"version":"3.37.3"},"reference-count":24,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Orthop Unfall"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Das Ziel der vorliegenden Arbeit ist es, die Versorgungssituation in Deutschland in Hinblick auf den Nutzen prophylaktischer und empirischer Antibiotikatherapie zu erheben. Unterschieden\n          wird zwischen prim\u00e4rer Endoprothetik und der Versorgung periprothetischer Gelenkinfektionen (PJI). Zu diesem Zweck wurde eine Umfrage in deutschen Universit\u00e4tskliniken und BG-Kliniken\n          (Fachbereiche Orthop\u00e4die und\/oder Unfallchirurgie) mittels Fragebogen durchgef\u00fchrt. Die daraus resultierenden Umfragedaten wurden anschlie\u00dfend mit zuvor ver\u00f6ffentlichten Daten zur\n          antimikrobiellen Behandlung von n=81 PJI-Patienten, die zwischen 2017 und 2020 in unserer Abteilung behandelt wurden, verglichen.<\/jats:p><jats:p>Hinsichtlich der prophylaktischen Antibiotikagabe im Kontext der Prim\u00e4rendoprothetik ergab sich ein homogenes Bild. In 93,2 % (elektiv) und 88,6 % (Frakturbehandlung) der Kliniken wurden\n          Cephalosporine der 1. und 2. Generation perioperativ zur Infektionsprophylaxe bei der prim\u00e4ren H\u00fcftendoprothetik verabreicht.<\/jats:p><jats:p>Die empirische Verabreichung von Antibiotika bei PJI zeigte ein deutlich inhomogeneres therapeutisches Bild. Am h\u00e4ufigsten wird eine Monotherapie mit einem\n          Aminopenicillin\/Betalaktamase-Inhibitor verordnet (38,7%); Cephalosporine der 1. und 2. Generation werden am zweith\u00e4ufigsten im Rahmen einer Monotherapie eingesetzt (18,2%).<\/jats:p><jats:p>Angesichts des globalen Problems der zunehmenden Antibiotikamultiresistenz muss der klinische Einsatz von Antibiotika sinnvoll und wirksam sein. Die vorliegenden Ergebnisse unterstreichen\n          die Notwendigkeit, das Bewusstsein hierf\u00fcr zu sch\u00e4rfen und bestehende Leitlinien zur Verabreichung empirischer Antibiotikatherapie bei PJI zu beachten.<\/jats:p>","DOI":"10.1055\/a-1773-1382","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T23:34:43Z","timestamp":1650929683000},"page":"654-659","source":"Crossref","is-referenced-by-count":0,"title":["Antibiotikaprophylaxe und empirische Antibiotikatherapie bei Prim\u00e4rendoprothetik und periprothetischen Gelenkinfektionen: Aktuelle Praxis und Bedarf an\n          Therapieoptimierung"],"prefix":"10.1055","volume":"161","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7221-3783","authenticated-orcid":false,"given":"Markus","family":"Rupp","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Unfallchirurgie, Universit\u00e4tsklinikum Regensburg, Regensburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0654-2076","authenticated-orcid":false,"given":"Nike","family":"Walter","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Unfallchirurgie, Universit\u00e4tsklinikum Regensburg, Regensburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5326-7273","authenticated-orcid":false,"given":"Susanne","family":"Baertl","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Unfallchirurgie, Universit\u00e4tsklinikum Regensburg, Regensburg, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0459-9092","authenticated-orcid":false,"given":"Siegmund","family":"Lang","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Unfallchirurgie, Universit\u00e4tsklinikum Regensburg, Regensburg, 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