{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T23:11:48Z","timestamp":1651014708591},"reference-count":13,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Purpose To describe cases diagnosed with pituitary macroadenoma during the follow-up of their primary ocular pathologies.<\/jats:p><jats:p>\n          Methods Charts of patients followed in the Centre for Ophthalmic Specialized Care for diverse pathologies and who had subsequently developed a pituitary macroadenoma were retrieved.\n\t\t\t\t\tThe primary pathologies were noted. The delay of the diagnosis after sufficiently compatible perimetric signs became available was calculated and the evolution after the neurosurgical\n\t\t\t\t\tintervention was reported.<\/jats:p><jats:p>\n          Results In total, from 2003 to 2020, 16\/14\u200a966 (0.1%) pituitary macroadenoma patients were recorded. In 10 patients, the disease was noted in their history. In 6 patients (2 females,\n\t\t\t\t\t4 males; 0.04%), macroadenoma occurred during the follow-up for their primary ocular pathologies. Mean age at first presentation was 65.16\u2009\u00b1\u20098.52 years. Primary pathologies included\n\t\t\t\t\tamblyopia (1), glaucoma (2), cataract (4), and uveitis (2). Mean duration of symptoms was 18.17\u2009\u00b1\u200913.11 months. Mean delay from first suspicious visual field signs to diagnosis was\n\t\t\t\t\t125\u2009\u00b1\u2009207.93 days. All patients underwent one surgical treatment with or without radiotherapy except one where a second intervention was required. All patients have seen their visual field\n\t\t\t\t\timprove after surgical intervention. Mean preoperative Mean defect (MD) was 13.43\u2009\u00b1\u20098.68\u2009dB OD and 13.4\u2009\u00b1\u20095.07\u2009dB OS. Mean postoperative MD was 8.2\u2009\u00b1\u200910.27\u2009dB OD and 5.42\u2009\u00b1\u20094.12\u2009dB OS.<\/jats:p><jats:p>\n          Conclusion Pituitary macroadenomas are prone to be missed or diagnosed with delay when ophthalmic patients are already followed for another pathology that prevents the clinician from\n\t\t\t\t\tdiligently evoking the diagnosis. Despite profound visual field loss, visual recovery was almost complete in 4\/6 patients, indicating that even diagnostic delay did not preclude recovery in\n\t\t\t\t\tour series.<\/jats:p>","DOI":"10.1055\/a-1778-3249","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T22:36:36Z","timestamp":1651012596000},"page":"468-475","source":"Crossref","is-referenced-by-count":0,"title":["Pituitary Macroadenoma: Fooling the Ophthalmologist before Giving Him the Role of the Whistle-Blower"],"prefix":"10.1055","volume":"239","author":[{"given":"Lara","family":"Tran","sequence":"additional","affiliation":[{"name":"Inflammatory and Retinal Eye Diseases, Centre for Ophthalmic Specialized Care, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Papasavvas","sequence":"additional","affiliation":[{"name":"Inflammatory and Retinal Eye Diseases, Centre for Ophthalmic Specialized Care, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Carl P.","family":"Herbort","sequence":"additional","affiliation":[{"name":"Inflammatory and Retinal Eye Diseases, Centre for Ophthalmic Specialized Care, Lausanne, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,4,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s11102-018-0869-3","article-title":"Epidemiology, clinical presentation and diagnosis of non-functioning pituitary adenomas","volume":"21","author":"G Ntali","year":"2018","journal-title":"Pituitary"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s11060-010-0302-x","article-title":"A prospective study of nonfunctioning pituitary adenomas: presentation, management, and clinical outcome","volume":"102","author":"L Chen","year":"2011","journal-title":"J Neurooncol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/j.endinu.2017.05.009","article-title":"Clinically non-functioning pituitary adenomas: Pathogenic, diagnostic and therapeutic aspects","volume":"64","author":"M Mercado","year":"2017","journal-title":"Endocrinol Diabetes Nutr"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1210\/jcem.85.1.6309","article-title":"Pituitary tumor registry: a\u00a0novel clinical resource","volume":"85","author":"M R Drange","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"823","DOI":"10.1530\/eje.1.02298","article-title":"Non-functioning pituitary adenoma database: a useful resource to improve the clinical management of pituitary tumors","volume":"155","author":"E Ferrante","year":"2006","journal-title":"Eur J Endocrinol"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1016\/j.jocn.2014.01.005","article-title":"Visual acuity and pattern of visual field loss at presentation in pituitary adenoma","volume":"21","author":"S Ogra","year":"2014","journal-title":"J Clin Neurosci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"W512","DOI":"10.2214\/AJR.15.14527","article-title":"Visual Defects in Patients With Pituitary Adenomas: The\u00a0Myth of Bitemporal Hemianopsia","volume":"205","author":"I H Lee","year":"2015","journal-title":"AJR Am J Roentgenol"},{"key":"ref9","first-page":"66","article-title":"Visual field testing for glaucoma \u2013 a practical guide","volume":"25","author":"D C Broadway","year":"2012","journal-title":"Community Eye Health"},{"key":"ref10","first-page":"13","article-title":"[Influence of cataract on automated perimetry]","volume":"29","author":"K Yao","year":"1993","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"480","DOI":"10.1016\/0002-9394(88)90887-2","article-title":"Quantifying visual field damage caused by cataract","volume":"106","author":"U Guthauser","year":"1988","journal-title":"Am J Ophthalmol"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1097\/OPX.0000000000000842","article-title":"Effect of Cataract Opacity Type and Glaucoma Severity on Visual Field Index","volume":"93","author":"H J Chung","year":"2016","journal-title":"Optom Vis Sci"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"283","DOI":"10.3171\/2011.6.JNS101663","article-title":"Factors associated with delay to pituitary adenoma diagnosis in patients with visual loss","volume":"116","author":"A Jahangiri","year":"2012","journal-title":"J Neurosurg"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"100765","DOI":"10.1016\/j.preteyeres.2019.06.001","article-title":"Visual loss and recovery in chiasmal compression","volume":"73","author":"H V Danesh-Meyer","year":"2019","journal-title":"Prog Retin Eye Res"}],"container-title":["Klinische Monatsbl\u00e4tter f\u00fcr Augenheilkunde"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1778-3249.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T22:38:44Z","timestamp":1651012724000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1778-3249"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":13,"journal-issue":{"issue":"04","published-online":{"date-parts":[[2022,4,26]]},"published-print":{"date-parts":[[2022,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1778-3249","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0023-2165","1439-3999"],"issn-type":[{"value":"0023-2165","type":"print"},{"value":"1439-3999","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}