{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:35:32Z","timestamp":1789472132218,"version":"build-2803163510"},"reference-count":36,"publisher":"Georg Thieme Verlag KG","issue":"04","funder":[{"name":"Sao Paulo Research Foundation","award":["2018\/10789\u20134"],"award-info":[{"award-number":["2018\/10789\u20134"]}]},{"name":"Sao Paulo Research Foundation","award":["2014\/03989\u20136"],"award-info":[{"award-number":["2014\/03989\u20136"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The aim of the study was to clarify the relationship and the time of aldosterone\n                    and renin recoveries at immediate and long-term follow-up in\n                    aldosterone-producing adenoma (APA) patients who underwent adrenalectomy.\n                    Prospective and longitudinal protocol in a cohort of APA patients was followed\n                    in a single center. Among 43 patients with primary aldosteronism (PA), thirteen\n                    APA patients were enrolled in this study. Blood was collected for aldosterone,\n                    renin, potassium, creatinine, cortisol, and ACTH before and 1, 3, 5, 7, 15, 30,\n                    60, 90, 120, 180, 270, 360 days after adrenalectomy. At diagnosis, most patients\n                    (84%) had hypokalemia and high median aldosterone levels (54.8;\n                    24.0\u2013103\u2009ng\/dl) that decreased to undetectable\n                    (&lt;2.2) or very low (&lt;3.0) levels between fifth to seventh days\n                    after surgery; then, between 3\u201312 months, its levels gradually increased\n                    to the lower normal range. The suppressed renin (2.3;\n                    2.3\u20132.3\u2009mU\/l) became detectable between the fifteen and\n                    thirty days after surgery, remaining normal throughout the study. The\n                    aldosterone took longer than renin to recover (60 vs.15 days; p&lt;0.002)\n                    and patients with higher aldosterone had later recovery (p=0.03). The\n                    cortisol\/ACTH levels remained normal despite the presence of a\n                    post-operative hypoaldosteronism. Blood pressure and antihypertensive\n                    requirement decreased after adrenalectomy. In conclusion, our prospective study\n                    shows the borderline persistent post-operative hypoaldosteronism in the presence\n                    of early renin recovery indicating incapability of the zona glomerulosa of the\n                    remaining adrenal gland to produce aldosterone. These findings contribute to the\n                    comprehension of differences in renin and aldosterone regulation in APA\n                    patients, although both are part of the same interconnected system.<\/jats:p>","DOI":"10.1055\/a-1778-4002","type":"journal-article","created":{"date-parts":[[2022,4,12]],"date-time":"2022-04-12T22:48:01Z","timestamp":1649803681000},"page":"224-231","source":"Crossref","is-referenced-by-count":7,"title":["Early Renin Recovery After Adrenalectomy in Aldosterone-Producing\n                    Adenomas: A Prospective Study"],"prefix":"10.1055","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6744-9441","authenticated-orcid":false,"given":"Livia M.","family":"Mermejo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Sao Paulo, Ribeirao\n                    Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula C.L.","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Sao Paulo, Ribeirao\n                    Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos A.F.","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anatomy, University of Sao Paulo, Ribeirao\n                    Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio","family":"Tucci","sequence":"additional","affiliation":[{"name":"Department of Surgery and Anatomy, University of Sao Paulo, Ribeirao\n                    Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdair F.","family":"Muglia","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Hematology and Oncology, University of\n                    Sao Paulo, Ribeirao Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Elias","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Hematology and Oncology, University of\n                    Sao Paulo, Ribeirao Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonir R.","family":"Antonini","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Sao Paulo, Ribeirao Preto, SP,\n                    Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"de Castro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Sao Paulo, Ribeirao\n                    Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8096-6803","authenticated-orcid":false,"given":"Ayrton C.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Sao Paulo, Ribeirao\n                    Preto, SP, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,4,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/joim.12831","article-title":"Diagnosis and treatment of primary aldosteronism: practical clinical\n                    perspectives","volume":"285","author":"W F Young","year":"2019","journal-title":"J Intern Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"10","DOI":"10.7326\/M20-0065","article-title":"The unrecognized prevalence of primary aldosteronism: a cross-sectional\n                    study","volume":"173","author":"J M Brown","year":"2020","journal-title":"Ann Intern Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2826","DOI":"10.1210\/jc.2016-1472","article-title":"Study heterogeneity and estimation of prevalence of primary aldosteronism: a\n                    systematic review and meta-regression analysis","volume":"101","author":"S C K\u00e4yser","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref4","first-page":"3","article-title":"Presidential address. 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