{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:18Z","timestamp":1740126798622,"version":"3.37.3"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"11","funder":[{"name":"durch die Else Kr\u00f6ner-Fresenius-Stiftung","award":["22\/08\/\/A 06\/08"],"award-info":[{"award-number":["22\/08\/\/A 06\/08"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychother Psychosom Med Psychol"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die Diagnose des Mayer-Rokitansky-K\u00fcster-Hauser Syndroms (MRKHS), eine\n                    seltene Variante der weiblichen Geschlechtsentwicklung, wird meist in der\n                    Pubert\u00e4t gestellt. Die Verunsicherung im Selbstbild, die\n                    Unm\u00f6glichkeit schwanger zu werden f\u00fchren h\u00e4ufig zu\n                    deutlicher Belastung. Obwohl eine psychosomatische Begleitung in der Literatur\n                    konsistent empfohlen wird gibt es bislang nur wenige Studien zu psychischen\n                    Aspekten von MRKHS. Ziel dieser Studie ist es, die Lebensqualit\u00e4t und\n                    Belastung von Frauen mit MRKHS bei der operativen Anlage einer Neovagina zu\n                    untersuchen und andererseits Effekte einer Intervention zur Vorbereitung und\n                    Unterst\u00fctzung w\u00e4hrend der Behandlung zu evaluieren. Methoden An\n                    einem \u00fcberregionalen Zentrum zur Neovaginaanlage wurde im Rahmen einer\n                    explorativen quasi-experimentellen Pr\u00e4-Post-Untersuchung allen\n                    Patientinnen eine psychosomatische Intervention angeboten (Interventionsgruppe\n                    IG, n=23) und vor Operation (t0) sowie sechs Monate danach (t1) die\n                    sexuelle Funktion (FSFI), psychische Belastung (PHQ-D) und gesundheitsbezogene\n                    Lebensqualit\u00e4t (SF-12) erhoben. Diese wurden mit den Daten einer zuvor\n                    sowie im Anschluss an den Interventionszeitraum erhobenen Stichprobe verglichen\n                    (Vergleichsgruppe VG, n=30). Ergebnisse W\u00e4hrend die\n                    k\u00f6rperliche Lebensqualit\u00e4t (SF-12) beider Gruppen zu beiden\n                    Zeitpunkten unauff\u00e4llig war, zeigte sich eine signifikante\n                    Beeintr\u00e4chtigung in der psychischen Lebensqualit\u00e4t. Beide\n                    Gruppen (IG, VG) verbesserten sich von t0 zu t1 in ihrer sexuellen Funktion\n                    (FSFI) und zeigten niedrigere Depressionswerte (PHQ-D). Die im Rahmen dieser\n                    Studie entwickelte Kurzintervention wurde von den Betroffenen gut akzeptiert und\n                    als hilfreich bewertet. Diese subjektiv empfundene Wirksam-keit der Intervention\n                    zeigte sich jedoch nicht durch eine Verbesserung auf der\n                    Lebensqualit\u00e4tsskala (SF-12) und Depressionsskala (PHQ-D).\n                    Schlussfolgerung Die Betroffenen zeigen eine deutliche, klinisch relevante\n                    Belastung (SF-12), die sich aber nicht in Form psychischer Komorbidit\u00e4t\n                    (PHQ-D) abbildet. Diese scheinbare Diskrepanz weist auf psychisch stabile Frauen\n                    mit akuter Belastung durch die Diagnose der Variante der Geschlechtsentwicklung\n                    hin. F\u00fcr sie scheint ein niederschwelliges Unterst\u00fctzungsangebot\n                    mit supportivem Charakter zur Begleitung w\u00e4hrend der operativen\n                    Behandlung notwendig und hilfreich. Die rekonstruktive Therapie zur Anlage einer\n                    Neovagina scheint die psychische Lebensqualit\u00e4t positiv zu beeinflussen.\n                    Dass eine Schwangerschaft aufgrund des fehlenden Uterus weiterhin nicht\n                    m\u00f6glich ist k\u00f6nnte ein Grund f\u00fcr das Nicht-Erreichen der\n                    Lebensqualit\u00e4t der Durchschnittsbev\u00f6lkerung sein.<\/jats:p>","DOI":"10.1055\/a-1778-5194","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T22:54:58Z","timestamp":1651618498000},"page":"473-480","source":"Crossref","is-referenced-by-count":0,"title":["Belastung von Betroffenen mit MRKH-Syndrom: Effekt einer Intervention\n                    zur Unterst\u00fctzung bei Neovagina-Anlage"],"prefix":"10.1055","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6569-921X","authenticated-orcid":false,"given":"Norbert","family":"Sch\u00e4ffeler","sequence":"additional","affiliation":[{"name":"Abteilung Psychosomatische Medizin und Psychotherapie, Medizinische\n                    Universit\u00e4tsklinik, Universit\u00e4tsklinikum T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Abteilung Psychosomatische Medizin und Psychotherapie, Medizinische\n                    Universit\u00e4tsklinik, Universit\u00e4tsklinikum T\u00fcbingen,\n                    T\u00fcbingen, Germany"},{"name":"Institut f\u00fcr transkulturelle Gesundheitsforschung, Duale\n                    Hochschule Baden-W\u00fcrttemberg \u2013 Villingen Schwenningen,\n                    Villingen-Schwenningen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernadette","family":"Schenk","sequence":"additional","affiliation":[{"name":"Universit\u00e4ts-Frauenklinik, Universit\u00e4tsklinikum\n                    T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorit","family":"Sch\u00f6ller","sequence":"additional","affiliation":[{"name":"Universit\u00e4ts-Frauenklinik, Universit\u00e4tsklinikum\n                    T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diethelm","family":"Wallwiener","sequence":"additional","affiliation":[{"name":"Universit\u00e4ts-Frauenklinik, Universit\u00e4tsklinikum\n                    T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8873-0486","authenticated-orcid":false,"given":"Paul","family":"Enck","sequence":"additional","affiliation":[{"name":"Abteilung Psychosomatische Medizin und Psychotherapie, Medizinische\n                    Universit\u00e4tsklinik, Universit\u00e4tsklinikum T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Teufel","sequence":"additional","affiliation":[{"name":"Abteilung Psychosomatische Medizin und Psychotherapie, Medizinische\n                    Universit\u00e4tsklinik, Universit\u00e4tsklinikum T\u00fcbingen,\n                    T\u00fcbingen, Germany"},{"name":"Klinik f\u00fcr Psychosomatische Medizin und Psychotherapie,\n                    LVR-Klinikum Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1659-4440","authenticated-orcid":false,"given":"Stephan","family":"Zipfel","sequence":"additional","affiliation":[{"name":"Abteilung Psychosomatische Medizin und Psychotherapie, Medizinische\n                    Universit\u00e4tsklinik, Universit\u00e4tsklinikum T\u00fcbingen,\n                    T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4546-9438","authenticated-orcid":false,"given":"Katharina","family":"Rall","sequence":"additional","affiliation":[{"name":"Universit\u00e4ts-Frauenklinik, Universit\u00e4tsklinikum\n                    T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Brucker","sequence":"additional","affiliation":[{"name":"Universit\u00e4ts-Frauenklinik, Universit\u00e4tsklinikum\n                    T\u00fcbingen, T\u00fcbingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/S0015-0282(01)01963-X","article-title":"A population-based study of the incidence of M\u00fcllerian aplasia in\n                    Finland","volume":"76","author":"K Aittom\u00e4ki","year":"2001","journal-title":"Fertility and sterility"},{"key":"ref2","first-page":"329","article-title":"Artificial vagina","volume":"37","author":"J Engstad","year":"1917","journal-title":"The Lancet"},{"issue":"10","key":"ref3","doi-asserted-by":"publisher","first-page":"R202","DOI":"10.1055\/s-2005-872941","article-title":"GebFra- Refresher: Vaginale und uterine Fehlbildungen Teil 1","volume":"65","author":"P Oppelt","year":"2005","journal-title":"Geburtshilfe und Frauenheilkunde"},{"issue":"11","key":"ref4","doi-asserted-by":"publisher","first-page":"R221","DOI":"10.1055\/s-2005-873011","article-title":"GebFra- Refresher: Vaginale und uterine Fehlbildungen Teil 2","volume":"65","author":"S Brucker","year":"2005","journal-title":"Geburtshilfe und Frauenheilkunde"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/j.fertnstert.2007.08.070","article-title":"Neovagina creation in vaginal agenesis: development of a new laparoscopic\n                    Vecchietti-based procedure and optimized instruments in a prospective\n                    comparative interventional study in 101 patients","volume":"90","author":"S Brucker","year":"2008","journal-title":"Fertility and sterility"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1055\/s-2003-44701","article-title":"Optimierung der laparoskopisch-assistierten Neovagina-Anlage durch neue\n                    Applikationsinstrumente inklusive einem neuen mechanischen Spannapparat","volume":"64","author":"S Brucker","year":"2004","journal-title":"Geburtshilfe und Frauenheilkunde"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.jpag.2014.02.002","article-title":"Laparoscopically assisted neovaginoplasty in vaginal agenesis: a long-term\n                    outcome study in 240 patients","volume":"27","author":"K Rall","year":"2014","journal-title":"Journal of pediatric and adolescent gynecology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.jpag.2008.11.006","article-title":"Mayer-Rokitansky-Kuster-Hauser Syndrome: Sexuality, Psychological Effects, and\n                    Quality of Life","volume":"22","author":"E J Bean","year":"2009","journal-title":"Journal of Pediatric & Adolescent Gynecology"},{"key":"ref9","first-page":"340","article-title":"Psychologic aspects of vaginal agenesis","volume":"30","author":"M L Poland","year":"1985","journal-title":"The Journal of reproductive medicine"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1053\/ob.1996.v175.a74926","article-title":"Long-term results after operatiove correction of vaginal aplasia","volume":"175","author":"V J M\u00f6bus","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/01443610500443170","article-title":"Congenital abnormalities of the genital tract: management or mismanagement?","volume":"26","author":"D K Edmonds","year":"2006","journal-title":"Journal of Obstetrics and Gynaecology"},{"key":"ref12","first-page":"125","article-title":"Women after surgically corrected vaginal aplasia: a follow-up of psychosexual\n                    rehabilitation","volume":"53","author":"V M\u00f6bus","year":"1993","journal-title":"Geburtsh Frauenheilk"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1093\/humrep\/dez130","article-title":"Sexual functioning, sexual esteem, genital self-image and psychological and\n                    relational functioning in women with Mayer-Rokitansky-Kuster-Hauser syndrome: a\n                    case-control study","volume":"34","author":"PT M Weijenborg","year":"2019","journal-title":"Human reproduction (Oxford, England)"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/s10508-006-9054-2","article-title":"Assesment of Sexual Functioning, Mental Health, and Life Goals in Women with\n                    Vaginal Agenesis","volume":"35","author":"E Morgan","year":"2006","journal-title":"Archives of Sexual Behaviour"},{"key":"ref15","first-page":"10","article-title":"Long Term Findings Concerning the Mental and Physical Condition, Quality of Life\n                    and Sexuality after Laparoscopically Assisted Creation of a Neovagina (Modified\n                    Vecchietti Technique) in Young MRKHS\n                    (Mayer-Rokitansky-K\u00fcster-Hauser-Syndrome) Patients","author":"K Rall","year":"2021","journal-title":"Journal of clinical medicine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/S0002-9378(03)00938-4","article-title":"McIndoe procedure for vaginal agenesis: long-term outcome and effect on quality\n                    of life","volume":"189","author":"C J Klingele","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/0002-9378(93)90283-O","article-title":"Long-term psychosexual and psychological performance of patients with a sigmoid\n                    neovagina","volume":"169","author":"I Freundt","year":"1993","journal-title":"American journal of obstetrics and gynecology"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei152","article-title":"Sexuality after laparoscopic Davydov in patients affected by congenital complete\n                    vaginal agenesis associated with uterine agenesis or hypoplasia","author":"A Giannesi","year":"2005","journal-title":"Human Reproduction"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1093\/humrep\/dem074","article-title":"Normalization of the vagina by dilator treatment alone in Complete Androgen\n                    Insensitivity Syndrome and Mayer-Rokitansky-Kuster-Hauser Syndrome","volume":"22","author":"I S Ismail-Pratt","year":"2007","journal-title":"Human Reproduction"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2296","DOI":"10.1093\/humrep\/dem167","article-title":"A randomized controlled trial of a cognitive-behavioural group intervention\n                    versus waiting-list control for women with uterovaginal agenesis\n                    (Mayer-Rokitansky-K\u00fcster-Hauser syndrome: MRKH)","volume":"22","author":"J G Heller-Boersma","year":"2007","journal-title":"Human Reproduction"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1471-0528.2000.tb13232.x","article-title":"The effect of a group programme on women with the\n                    Mayer-Rokitansky-K\u00fcster-Hauser-Syndrome","volume":"107","author":"PT M Weijenborg","year":"2000","journal-title":"BJOG: An International Journal of Obstetrics &\n                    Gynaecology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1080\/1354850021000059232","article-title":"Living with an incomplete vagina and womb: An interpretative phenomenological\n                    analysis of the experience of vaginal agenesis","volume":"8","author":"R E Holt","year":"2003","journal-title":"Psychology, Health & Medicine"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1016\/j.juro.2010.03.078","article-title":"Sexuality and psychosocial functioning in young women after\n                    colovaginoplasty","volume":"184","author":"C Gatti","year":"2010","journal-title":"The Journal of urology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1055\/s-2002-36371","article-title":"Die Bedeutung einer stabilen Mutter-Tochter-Beziehung bei Patientinnen mit\n                    Mayer-Rokitansky-K\u00fcster-Syndrom und Neovagina","volume":"62","author":"E Loeser","year":"2002","journal-title":"Geburtshilfe und Frauenheilkunde"},{"volume-title":"Gesundheitsfragebogen f\u00fcr Patienten (PHQ-D). Manual und\n                    Testunterlagen","year":"2002","author":"B L\u00f6we","key":"ref26"},{"volume-title":"SF-36. Fragebogen zum Gesundheitszustand","year":"1998","author":"M Bullinger","key":"ref27"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1055\/s-2004-815815","article-title":"\u00dcberpr\u00fcfung der G\u00fcltigkeit und Zuverl\u00e4ssigkeit\n                    des deutschen Female Sexual Function Index (FSFI-d)","volume":"64","author":"M M Berner","year":"2004","journal-title":"Geburtshilfe und Frauenheilkunde"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/00926230590475206","article-title":"The female sexual function index (FSFI): cross-validation and development of\n                    clinical cutoff scores","volume":"31","author":"M Wiegel","year":"2005","journal-title":"Journal of sex & marital therapy"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1111\/j.1743-6109.2010.01742.x","article-title":"Prevalence of Sexual Dysfunction and Impact of Contraception in Female German\n                    Medical Students","volume":"7","author":"C W Wallwiener","year":"2010","journal-title":"Journal of Sexual Medicine"}],"container-title":["PPmP - Psychotherapie \u00b7 Psychosomatik \u00b7 Medizinische Psychologie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1778-5194.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,17]],"date-time":"2022-11-17T01:24:21Z","timestamp":1668648261000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1778-5194"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,3]]},"references-count":29,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2022,11,16]]},"published-print":{"date-parts":[[2022,11]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1778-5194","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0937-2032","1439-1058"],"issn-type":[{"type":"print","value":"0937-2032"},{"type":"electronic","value":"1439-1058"}],"subject":[],"published":{"date-parts":[[2022,5,3]]}}}