{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T23:12:54Z","timestamp":1659741174057},"reference-count":16,"publisher":"Georg Thieme Verlag KG","issue":"04","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nuklearmedizin"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Hintergrund Die Skelettszintigrafie ist eine sensitive Methode f\u00fcr die Darstellung von Knochenmetastasen. Trotz der festen Etablierung in die klinische Routine gibt es kaum Daten aus gr\u00f6\u00dferen homogenen Kollektiven zur Wertigkeit der Skelettszintigrafie im Rahmen des Stagings.<\/jats:p><jats:p>\n          Ziel Ziel unserer Arbeit war die Evaluierung der Real-Life-Performance der Skelettszintigrafie als Staginguntersuchung bei Patientinnen mit der Erstdiagnose eines Mammakarzinoms.<\/jats:p><jats:p>\n          Patienten und Methoden Wir werteten retrospektiv die Daten der im Jahr 2015 in unserer Klinik mittels Skelettszintigrafie untersuchten Patientinnen aus. Zus\u00e4tzlich wurde \u00fcber einen Zeitraum von 30 Monaten evaluiert, ob sich im Verlauf diese Ergebnisse best\u00e4tigten; hierzu wurden anschlie\u00dfende Untersuchungen ausgewertet.<\/jats:p><jats:p>\n          Ergebnisse 207\/258 Patientinnen zeigten in der initialen Skelettszintigrafie keine verd\u00e4chtigen Befunde, bei 48 zeigte sich ein unklarer Befund, weshalb bei 42 Patientinnen weitere Diagnostik angeschlossen wurde. Im Follow-up wurden bei 4 Patientinnen neue Skelettmetastasen gefunden, diese hatten alle in der Prim\u00e4rdiagnostik Szintigrafiebefunde, die als \u201eunklar\u201c gewertet wurden. Es ergab sich je nach Wertung des Ereignisses (metastasenverd\u00e4chtig\/metastasenverd\u00e4chtig und unklar) eine Sensitivit\u00e4t von 37,5%\/100%, eine Spezifit\u00e4t von 100%\/80%, ein positiv pr\u00e4diktiver Wert von 100%\/15,7% und ein negativ pr\u00e4diktiver Wert von 98%\/100%.<\/jats:p><jats:p>\n          Schlussfolgerung Mittels der Skelettszintigrafie und weiterer Abkl\u00e4rung konnte in 99,2% der vollst\u00e4ndig untersuchten Patientinnen ein klinisch aussagekr\u00e4ftiger Befund erhoben werden, welcher sich im Follow-up best\u00e4tigte. Dieses Ergebnis zeigt die gute Real-Life-Performance der Skelettszintigrafie als Staginguntersuchung bei Patientinnen mit erstdiagnostiziertem Mammakarzinom.<\/jats:p>","DOI":"10.1055\/a-1780-8378","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:14:18Z","timestamp":1649290458000},"page":"308-313","source":"Crossref","is-referenced-by-count":0,"title":["Hohe klinische Wertigkeit der Skelettszintigrafie beim Staging des Mammakarzinoms"],"prefix":"10.1055","volume":"61","author":[{"given":"Friederike","family":"Eilsberger","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, University Hospital of Giessen and Marburg Campus Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Girmond","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, University Hospital of Giessen and Marburg Campus Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jelena","family":"Boekhoff","sequence":"additional","affiliation":[{"name":"Gynecology, University Hospital of Giessen and Marburg Campus Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damiano","family":"Librizzi","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, University Hospital of Giessen and Marburg Campus Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Luster","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, University Hospital of Giessen and Marburg Campus Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Pfestroff","sequence":"additional","affiliation":[{"name":"Nuclear Medicine, University Hospital of Giessen and Marburg Campus Marburg, Marburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,4,6]]},"reference":[{"key":"ref2","volume-title":"Knochenmetastasen bei gyn\u00e4kologsichen Malignomen. in: Stenzel A, Fehm T, Hofbauer L, Jabok F (eds) Knochenmetastasen","author":"T Fehm","year":"2014"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2967\/jnumed.115.157867","article-title":"ImagingBone Metastases in Breast Cancer: Staging and Response Assessment","volume":"57","author":"GJR Cook","year":"2016","journal-title":"J Nucl Med"},{"issue":"08","key":"ref5","first-page":"1356","article-title":"Imaging of Malignant Bone Involvement by Morphologic, Scintigraphic, and Hybrid Modalities","volume":"46","author":"E Even-Sapir","year":"2005","journal-title":"J Nucl Med"},{"issue":"01","key":"ref6","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1111\/cbdd.13327","article-title":"Management of skeletal metastases; 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