{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:26:27Z","timestamp":1787502387243,"version":"build-2736575974"},"reference-count":18,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T00:00:00Z","timestamp":1645660800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background and study aims\u2002Acute esophageal perforation is a potentially life-threating condition that demands a multidisciplinary approach. Based on recently published data indicating that EVT may be effective in managing esophageal perforation, we report our institution\u2019s experience with EVT in this clinical setting.<\/jats:p>\n                  <jats:p>Patients and methods\u2002We retrospectively analyzed all 10 patients with acute esophageal perforation from May 2018 to January 2021, using descriptive statistics. The primary outcome was successful closure of the perforation. Secondary outcomes included the length of treatment, number of endoscopic procedures required, and complication rate.<\/jats:p>\n                  <jats:p>Results\u2002All patients (site of perforation: 4 upper, 2 middle, 4 lower esophagus; etiology: 8 iatrogenic, 2 foreign body ingestion) were treated with EVT successfully. In eight cases, EVT was started immediately after the perforation, in the other two cases 1 and 2 days later. The median (interquartile range) number of endoscopic procedures was 2.5 (range, 2\u20133) and the median duration of treatment was 7.5 days (range, 7\u201311.5). The sponge was placed in eight cases intraluminally, in the other two cases initially intracavitary. No complication occurred.<\/jats:p>\n                  <jats:p>Conclusions\u2002EVT is highly effective for managing acute esophageal perforation within 1 to 3 weeks. Immediate start of EVT to prevent abscess formation and induce defect closure is crucial.<\/jats:p>","DOI":"10.1055\/a-1781-0827","type":"journal-article","created":{"date-parts":[[2022,2,24]],"date-time":"2022-02-24T20:22:37Z","timestamp":1645734157000},"page":"E686-E693","source":"Crossref","is-referenced-by-count":18,"title":["Endoscopic vacuum therapy (EVT) for acute esophageal perforation: Could it replace surgery?"],"prefix":"10.1055","volume":"10","author":[{"given":"Petros","family":"Stathopoulos","sequence":"additional","affiliation":[{"name":"Division of Interdisciplinary Endoscopy, Department of Gastroenterology, University Hospital Marburg, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte","family":"Zumblick","sequence":"additional","affiliation":[{"name":"Division of Interdisciplinary Endoscopy, Department of Gastroenterology, University Hospital Marburg, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"W\u00e4chter","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery, University Hospital Marburg, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif","family":"Schiffmann","sequence":"additional","affiliation":[{"name":"Department of General, Visceral and Thoracic Surgery, Helios Hospital Aue, Aue, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas M.","family":"Gress","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, University Hospital Marburg, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Detlef","family":"Bartsch","sequence":"additional","affiliation":[{"name":"Department of Visceral, Thoracic and Vascular Surgery, University Hospital Marburg, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guido","family":"Seitz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, University Hospital Marburg, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike W.","family":"Denzer","sequence":"additional","affiliation":[{"name":"Division of Interdisciplinary Endoscopy, Department of Gastroenterology, University Hospital Marburg, Marburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/dote\/dox013","article-title":"Epidemiology, diagnosis, and management of esophageal perforations: systematic review","volume":"30","author":"E IK Sdralis","year":"2017","journal-title":"Dis 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Jung","year":"2021","journal-title":"Digestion"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s11605-018-04082-z","article-title":"Endoluminal vacuum therapy: How I do it","volume":"23","author":"S G Leeds","year":"2019","journal-title":"J Gastrointest Surg"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.athoracsur.2003.08.037","article-title":"Evolving options in the management of esophageal perforation","volume":"77","author":"C J Brinster","year":"2004","journal-title":"Ann Thorac Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/dote\/dox108","article-title":"Outcomes following the main treatment options in patients with a leaking esophagus: a systematic literature review","volume":"30","author":"S Persson","year":"2017","journal-title":"Dis Esophagus"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.5946\/ce.2017.027","article-title":"Efficacy of the over-the-scope clip system for treatment of gastrointestinal fistulas, leaks, and perforations: a Korean multi-center study","volume":"51","author":"H L Lee","year":"2018","journal-title":"Clin Endosc"},{"key":"ref9","first-page":"1","article-title":"Endoscopic vacuum therapy (EVT) in the management of oesophageal perforations and post-operative leaks","volume":"10","author":"S Mastoridis","year":"2020","journal-title":"Minim Invasive Ther Allied Technol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2507","DOI":"10.1007\/s00268-018-4463-7","article-title":"Endoluminal vacuum therapy (E-Vac): a treatment option in oesophagogastric surgery","volume":"42","author":"D J Pournaras","year":"2018","journal-title":"World J Surg"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"E257","DOI":"10.1111\/ans.13837","article-title":"Indications and efficacy of endoscopic vacuum-assisted closure therapy for upper gastrointestinal perforations","volume":"88","author":"G Ooi","year":"2018","journal-title":"ANZ J Surg"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"2687","DOI":"10.1007\/s00464-016-5265-3","article-title":"Successful closure of defects in the upper gastrointestinal tract by endoscopic vacuum therapy (EVT): a prospective cohort study","volume":"31","author":"M G Laukoetter","year":"2017","journal-title":"Surg Endosc"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s11605-015-3044-4","article-title":"Surgical endoscopic vacuum therapy for defects of the upper gastrointestinal tract","volume":"20","author":"F Kuehn","year":"2016","journal-title":"J Gastrointest Surg"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"E554","DOI":"10.1055\/s-0034-1392568","article-title":"Endoscopic vacuum therapy for esophageal perforations and leakages","volume":"3","author":"O M\u00f6schler","year":"2015","journal-title":"Endosc Int 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