{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T18:56:56Z","timestamp":1774637816964,"version":"3.50.1"},"reference-count":20,"publisher":"Georg Thieme Verlag KG","issue":"05","license":[{"start":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T00:00:00Z","timestamp":1652400000000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"J-CASE Research Grant 2019"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Endosc Int Open"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background and study aims\u2002Closure after endoscopic full-thickness resection (EFTR) is challenging. We previously developed a simple endoscopic closure method: line-assisted complete closure (LACC). We performed a pilot study using porcine models to evaluate the feasibility of modified LACC after gastric EFTR.<\/jats:p><jats:p>\n          Patients and methods\u2002Six live pigs were included. EFTR (greater curvature of the gastric antrum [n\u200a=\u200a3] and anterior wall of the gastric body [n\u200a=\u200a3]) was performed under general anesthesia and the defect after EFTR was closed by modified LACC. The pigs were observed until postoperative day 4 (Day 4). The closure site was endoscopically evaluated and the presence or absence of peritonitis and fluid leakage was evaluated. The outcomes were the success rate of modified LACC on the day of the procedure, maintenance of defect closure, presence of peritonitis or leakage, and clinical course.<\/jats:p><jats:p>\n          Results\u2002Once complete closure was successfully achieved in all cases, maintenance of closure on Day 4 was not achieved. However, there was neither peritonitis nor fluid leakage. The defect was completely covered by surrounding tissues on Day 4 and the clinical course was good in all cases.<\/jats:p><jats:p>\n          Conclusions\u2002The feasibility of modified LACC after gastric EFTR was demonstrated in porcine models. Further improvement is needed to maintain defect closure.<\/jats:p>","DOI":"10.1055\/a-1785-8589","type":"journal-article","created":{"date-parts":[[2022,5,13]],"date-time":"2022-05-13T22:30:15Z","timestamp":1652481015000},"page":"E609-E615","source":"Crossref","is-referenced-by-count":1,"title":["Modified line-assisted complete closure of the defect after gastric endoscopic full-thickness resection: a pilot study in porcine models"],"prefix":"10.1055","volume":"10","author":[{"given":"Yasushi","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Okayama University Hospital, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayasu","family":"Ohmori","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Okayama University Hospital, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junki","family":"Toyosawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Okayama University Hospital, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soichiro","family":"Ako","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Okayama University Hospital, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Okayama University Hospital, Okayama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2926","DOI":"10.1007\/s00464-011-1644-y","article-title":"Endoscopic full-thickness resection without laparoscopic assistance for gastric submucosal tumors 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Shi","year":"2013","journal-title":"Endoscopy"},{"key":"ref8","first-page":"4356","article-title":"Therapeutic application of purse-string sutures with nylon loops and metal clips under single-channel endoscopy for repair of gastrointestinal wall defects","volume":"15","author":"Z Qiao","year":"2018","journal-title":"Exp Ther Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1055\/s-0043-110668","article-title":"Endoscopic hand-suturing for defect closure after gastric endoscopic submucosal dissection: a pilot study in animals and in humans","volume":"49","author":"O Goto","year":"2017","journal-title":"Endoscopy"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.gie.2019.12.046","article-title":"Endoscopic hand-suturing is feasible, safe, and may reduce bleeding risk after gastric endoscopic submucosal dissection: a multicenter pilot study (with video)","volume":"91","author":"O Goto","year":"2020","journal-title":"Gastrointest Endosc"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.gie.2019.12.032","article-title":"Endoscopic suturing promotes healing of mucosal defects after gastric endoscopic submucosal dissection: endoscopic and histologic analyses in in vivo porcine models (with video)","volume":"91","author":"T Akimoto","year":"2020","journal-title":"Gastrointest Endosc"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"E51","DOI":"10.1055\/a-1287-7482","article-title":"Traction-assisted endoscopic full-thickness resection followed by O-ring and over-the-scope clip closure in the stomach: an animal experimental study","volume":"9","author":"H Kobara","year":"2021","journal-title":"Endosc Int Open"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"E207","DOI":"10.1055\/a-0881-2702","article-title":"Underwater full-thickness resection of a duodenal bulb gastrointestinal stromal tumor with OverStitch 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