{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T01:36:29Z","timestamp":1763429789535,"version":"3.37.3"},"reference-count":25,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n            Objective\u2003Safety and efficacy data on controlled hypothermia (CH) for neonates with moderate to severe hypoxic ischemic encephalopathy has been extrapolated to a subgroup of these patients who also require extracorporeal membrane oxygenation for refractory persistent pulmonary hypertension of the newborn (PPHN). However, safety data on the concomitant use of CH and extracorporeal membrane oxygenation (ECMO) are lacking.<\/jats:p><jats:p>\n            Methods\u2003This is a single-center retrospective study of neonates \u226535 weeks' gestation with refractory PPHN who required ECMO between January 2010 and December 2020. Study groups were divided into those receiving CH\/ECMO versus ECMO only. Baseline characteristics, short-term outcomes, and brain magnetic resonance imaging (MRI) data were compared.<\/jats:p><jats:p>\n            Results\u2003A total of 36 neonates who received ECMO for refractory PPHN were included. Of these, 44.4% (n\u2009=\u200916) received CH\/ECMO and 55.6% (n\u2009=\u200920) received ECMO only. Bleeding complications were more common in CH\/ECMO group 50% (n\u2009=\u20098) versus ECMO only 15% (n\u2009=\u20093, p\u2009=\u20090.023). T1 brain MRI severity scores were higher in CH\/ECMO group versus ECMO only group, however, there were no statistical difference in T2 and diffusion-weighted image scores. Functional status and survival to discharge were comparable between groups.<\/jats:p><jats:p>\n            Conclusion\u2003In our cohort, neonates who received CH\/ECMO had higher bleeding complications than ECMO only group with comparable functional status and survival at discharge.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1786-8688","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T23:59:55Z","timestamp":1646351995000},"page":"1062-1068","source":"Crossref","is-referenced-by-count":2,"title":["Bleeding Complications in Neonates Receiving Extracorporeal Membrane Oxygenation and Controlled Hypothermia"],"prefix":"10.1055","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4028-7213","authenticated-orcid":false,"given":"Swosti","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Drexel University College of Medicine Philadelphia, Pennsylvania"},{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania"},{"name":"Division of Extracorporeal Membrane Support, Department of Pediatrics, Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vilmaris Quinones","family":"Cardona","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Drexel University College of Medicine Philadelphia, Pennsylvania"},{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania"},{"name":"Division of Extracorporeal Membrane Support, Department of Pediatrics, Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erica","family":"Poletto","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Drexel University College of Medicine Philadelphia, Pennsylvania"},{"name":"Division of Radiology, Department of Pediatrics, Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ogechukwu","family":"Menkiti","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Drexel University College of Medicine Philadelphia, Pennsylvania"},{"name":"Division of Neonatal-Perinatal Medicine, Department of Pediatrics, Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania"},{"name":"Division of Extracorporeal Membrane Support, Department of Pediatrics, Saint Christopher's Hospital for Children, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,17]]},"reference":[{"issue":"02","key":"ref1","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1586\/eog.10.7","article-title":"Hypothermia for hypoxic-ischemic encephalopathy","volume":"5","author":"C M Cotten","year":"2010","journal-title":"Expert Rev Obstet Gynecol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1542\/peds.110.2.377","article-title":"Whole-body hypothermia for neonatal encephalopathy: animal observations as a basis for a randomized, controlled pilot study in term infants","volume":"110","author":"S Shankaran","year":"2002","journal-title":"Pediatrics"},{"issue":"08","key":"ref3","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1001\/archpediatrics.2011.43","article-title":"Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled 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An analysis of ELSO registry data","volume":"39","author":"A Polito","year":"2013","journal-title":"Intensive Care Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3389\/fped.2019.00366","article-title":"Anticoagulation in neonatal ECMO: an enigma despite a lot of effort!","volume":"7","author":"K Cashen","year":"2019","journal-title":"Front Pediatr"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1786-8688.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T13:44:00Z","timestamp":1730814240000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1786-8688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,3]]},"references-count":25,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2024,5,20]]},"published-print":{"date-parts":[[2024,6]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1786-8688","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"type":"print","value":"0735-1631"},{"type":"electronic","value":"1098-8785"}],"subject":[],"published-other":{"date-parts":[[2022,3,3]]},"published":{"date-parts":[[2022,3,3]]}}}