{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T21:08:41Z","timestamp":1753736921084},"reference-count":38,"publisher":"Georg Thieme Verlag KG","issue":"07\/08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Aufgrund steigender Fallzahlen der Alzheimer-Erkrankung und bislang eher\n                    m\u00e4\u00dfigem Erfolg der verf\u00fcgbaren symptomatischen und\n                    kausalen pharmakologischen Therapien besteht ein erheblicher Bedarf,\n                    nicht-pharmakologische Behandlungsm\u00f6glichkeiten zu erforschen. Im\n                    Bereich der nicht-invasiven Hirnstimulation (non-invasive brain stimulation;\n                    NIBS) wurden verschiedene Verfahren untersucht, insbesondere die transkranielle\n                    Magnetstimulation und die transkranielle elektrische Stimulation.\n                    Zus\u00e4tzlich wird derzeit die Tiefe Hirnstimulation (deep brain\n                    stimulation; DBS) als innovatives Verfahren zur gezielten Neuromodulation\n                    erforscht. Nicht-invasiven und invasiven Ans\u00e4tzen gemein ist der\n                    Versuch, neuronale Aktivit\u00e4t zu modulieren und kognitiv-mnestische\n                    Funktionen zu verbessern. Durch sekund\u00e4re Mechanismen wie die\n                    Langzeit-Potenzierung bei NIBS oder Neurogenese bei DBS k\u00f6nnten auch\n                    l\u00e4ngerfristige positive Effekte erzielt werden. Pr\u00e4klinische und\n                    klinische Studien ergaben bereits vielversprechende Ergebnisse bei Patientinnen\n                    und Patienten in fr\u00fchen Stadien der Alzheimer-Erkrankung. Inkonsistente\n                    Studien- und Stimulationsprotokolle sowie kleine Stichproben erschweren jedoch\n                    die Bewertung der Wirksamkeit. Weitere Forschungsbem\u00fchungen sind\n                    angebracht, um einen zeitnahen Einzug nicht-invasiver oder invasiver\n                    neuromodulatorischer Ans\u00e4tze in die klinische Praxis zu\n                    erm\u00f6glichen.<\/jats:p>","DOI":"10.1055\/a-1787-0335","type":"journal-article","created":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:52:30Z","timestamp":1651193550000},"page":"336-342","source":"Crossref","is-referenced-by-count":1,"title":["Stimulationsverfahren zur Behandlung von Demenzen"],"prefix":"10.1055","volume":"90","author":[{"given":"Ronja V.","family":"Fa\u00dfbender","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"Goedecke","sequence":"first","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Neurologie, Medizinische\n                    Fakult\u00e4t und Uniklinik K\u00f6ln, Universit\u00e4t zu\n                    K\u00f6ln, K\u00f6ln, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veerle","family":"Visser-Vandewalle","sequence":"additional","affiliation":[{"name":"Klinik und Poliklinik f\u00fcr Stereotaxie und Funktionelle\n                    Neurochirurgie, Medizinische Fakult\u00e4t und Uniklinik K\u00f6ln,\n                    Universit\u00e4t zu K\u00f6ln, K\u00f6ln, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gereon R.","family":"Fink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oezguer A.","family":"Onur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,4,28]]},"reference":[{"key":"ref1","volume-title":"Global Health Estimates 2020: Deaths by Cause, Age, Sex, by Country and by\n                    Region, 2000-2019","author":"Organization 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