{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T02:12:52Z","timestamp":1780539172073,"version":"3.54.1"},"reference-count":42,"publisher":"Georg Thieme Verlag KG","issue":"08","funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81571480"],"award-info":[{"award-number":["81571480"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Sichuan Science and Technology Department Major Science and Technology Special Project","award":["22ZDYF1470"],"award-info":[{"award-number":["22ZDYF1470"]}]},{"name":"Luzhou Municipal People's Government-Southwest Medical University Science and Technology Strategic Cooperation Project","award":["2020LZXNYDJ03"],"award-info":[{"award-number":["2020LZXNYDJ03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:p>\n            Objectives\u2003Our previous study showed that resveratrol (Res) attenuates apoptosis and mitochondrial dysfunction in alveolar epithelial cell injury induced by hyperoxia by activating the SIRT1\/PGC-1\u03b1 signaling pathway. In the present study, we investigated whether Res protects against hyperoxia-induced lung injury in neonatal rats by activating SIRT1\/PGC-1\u03b1 signaling pathway.<\/jats:p><jats:p>\n            Methods\u2003Naturally delivered neonatal rats were randomly divided into six groups: normoxia\u2009+\u2009normal saline, normoxia\u2009+\u2009dimethyl sulfoxide (DMSO), normoxia\u2009+\u2009Res, hyperoxia\u2009+\u2009normal saline, hyperoxia\u2009+\u2009DMSO, and hyperoxia\u2009+\u2009Res. Lung tissue samples were collected on postnatal days 1, 7, and 14. Hematoxylin and eosin staining was used to evaluate lung development. Dual-immunofluorescence staining, real-time polymerase chain reaction, and western blotting were used to evaluate the levels of silencing information regulator 2-related enzyme 1 (SIRT1), peroxisome proliferator-activated receptor \u03b3 co-activator 1\u03b1 (PGC-1\u03b1), nuclear respiratory factor 1 (Nrf1), Nrf2, transcription factor A (TFAM) and citrate synthase, the number of mitochondrial DNA (mtDNA) and mitochondria, the integrity of mtDNA, and the expression of TFAM in mitochondria.<\/jats:p><jats:p>\n            Results\u2003We found that hyperoxia insulted lung development, whereas Res attenuated the hyperoxia lung injury. Res significantly upregulated the levels of SIRT1, PGC-1\u03b1, Nrf1, Nrf2, TFAM, and citrate synthase; promoted TFAM expression in the mitochondria; and increased the copy number of ND1 and the ratio of ND4\/ND1.<\/jats:p><jats:p>\n            Conclusion\u2003Our data suggest that Res attenuates hyperoxia-induced lung injury in neonatal rats, and this was achieved, in part, by activating the SIRT1\/PGC-1\u03b1 signaling pathway to promote mitochondrial biogenesis.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1787-3396","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T23:59:55Z","timestamp":1646351995000},"page":"1039-1049","source":"Crossref","is-referenced-by-count":9,"title":["Resveratrol Attenuates Hyperoxia Lung Injury in Neonatal Rats by Activating SIRT1\/PGC-1\u03b1 Signaling Pathway"],"prefix":"10.1055","volume":"41","author":[{"given":"Kun","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China"},{"name":"Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China"},{"name":"Sichuan Clinical Research Center for Birth Defects, Luzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0764-1946","authenticated-orcid":false,"given":"Menghan","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China"},{"name":"Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China"},{"name":"Sichuan Clinical Research Center for Birth Defects, Luzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7240-7318","authenticated-orcid":false,"given":"Yunchuan","family":"Shen","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China"},{"name":"Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China"},{"name":"Sichuan Clinical Research Center for Birth Defects, Luzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Kang","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China"},{"name":"Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China"},{"name":"Sichuan Clinical Research Center for Birth Defects, Luzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China"},{"name":"Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China"},{"name":"Sichuan Clinical Research Center for Birth Defects, Luzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenbin","family":"Dong","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China"},{"name":"Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China"},{"name":"Sichuan Clinical Research Center for Birth Defects, Luzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Lei","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China"},{"name":"Department of Perinatology, The Affiliated Hospital of Southwest Medical University, Luzhou, China"},{"name":"Sichuan Clinical Research Center for Birth Defects, Luzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"595634","DOI":"10.3389\/fmed.2021.595634","article-title":"SIRT1-related signaling pathways and their association with bronchopulmonary dysplasia","volume":"8","author":"K Yang","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.gene.2018.08.031","article-title":"Oxidative 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