{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T07:51:45Z","timestamp":1767340305659,"version":"3.37.3"},"reference-count":23,"publisher":"Georg Thieme Verlag KG","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Klin Monbl Augenheilkd"],"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Fragestellung Ziel dieser Studie war es, den Unterschied im Behandlungserfolg nach phototherapeutischer Keratektomie (PTK) bei Salzmann\u02bcscher nodul\u00e4rer Degeneration (SND) mittels\n          zweier Excimerlaser mit unterschiedlichen Spezifikationen zu untersuchen.<\/jats:p><jats:p>\n          Patienten und Methoden Im Zeitraum von 2007 bis 2017 wurden 272 PTKs, die an 246 Augen mit SND von 181 Patienten durchgef\u00fchrt wurden, retrospektiv untersucht. Bis 2014 wurde f\u00fcr die\n          PTK nach manueller Pannektomie der Excimerlaser MEL70 (Carl Zeiss Meditec Vertriebsgesellschaft mbH, Oberkochen, Deutschland) verwendet, danach der Amaris 750S (Schwind eye-tech-solutions\n          GmbH, Kleinostheim, Deutschland). Der Therapieerfolg wurde anhand folgender Parameter beurteilt: Visus, Refraktion und Astigmatismus sowie die Pachymetrie und die Endothelzellmessung zu den\n          Zeitpunkten T1\u2009=\u2009pr\u00e4operativ, T2\u2009=\u20096-Wochen-Kontrolle, T3\u2009=\u20096-Monats-Kontrolle. Zum Vergleich der Daten wurden der Wilcoxon-Mann-Whitney-U-Test und der Chi-Quadrat-Test mit einem\n          Signifikanzniveau von 5% genutzt.<\/jats:p><jats:p>\n          Ergebnisse Nach 6 Monaten stieg der Visus nur in der Schwind-Gruppe signifikant um 0,17\u2009\u00b1\u20090,33 (logMAR p\u2009&lt;\u20090,013). In der Zeiss-Gruppe stieg der Visus nur um 0,11\u2009\u00b1\u20090,36 (logMAR\n          p\u2009&lt;\u20090,057). Auch f\u00fcr die Refraktion konnte nach 6 Monaten nur f\u00fcr die Schwind-Gruppe eine signifikante \u00c4nderung um 3,35\u2009\u00b1\u20092,76\u2009dpt sph\u00e4risches \u00c4quivalent (SEQ) (p\u2009&lt;\u20090,001) gezeigt\n          werden. In der Zeiss-Gruppe ver\u00e4nderte sich das SEQ nicht signifikant (p\u2009&lt;\u20090,676). Der topografische Astigmatismus verbesserte sich nach 6 Monaten in beiden Studiengruppen signifikant um\n          1,73\u2009\u00b1\u20091,99\u2009dpt in der Schwind-Gruppe (p\u2009&lt;\u20090,001) und um 1,99\u2009\u00b1\u20092,21\u2009dpt in der Zeiss-Gruppe (p\u2009&lt;\u20090,0001). Haze musste in der Schwind-Gruppe in 12,7% der F\u00e4lle behandelt werden und in\n          der Zeiss-Gruppe in 16,2% der F\u00e4lle. Eine Endothelzellsch\u00e4digung zeigte sich in keiner der beiden Gruppen.<\/jats:p><jats:p>\n          Schlussfolgerung In beiden Studiengruppen profitierten die Patienten von einer PTK bei SND. F\u00fcr die Schwind-Gruppe konnte jedoch eine signifikant gr\u00f6\u00dfere Verbesserung von Visus und\n          Refraktion festgestellt werden als f\u00fcr die Zeiss-Gruppe. Im Gegensatz zum \u00fcblichen hyperopisierenden Effekt der PTK bei anderen Diagnosen zeigte sich bei SND ein sog. \u201emyopic shift\u201c, der\n          sich aus den oft mittelperipher liegenden SND-Knoten und dem damit verbundenen asymmetrischen Tr\u00e4nenfilmpooling pr\u00e4operativ erkl\u00e4ren l\u00e4sst.<\/jats:p>","DOI":"10.1055\/a-1788-3819","type":"journal-article","created":{"date-parts":[[2022,5,18]],"date-time":"2022-05-18T23:08:45Z","timestamp":1652915325000},"page":"1262-1268","source":"Crossref","is-referenced-by-count":3,"title":["Phototherapeutische Keratektomie bei Salzmann\u02bcscher nodul\u00e4rer Degeneration. Welche Auswirkung hat die Wahl des Excimerlasers auf den Erfolg der\n          Behandlung?"],"prefix":"10.1055","volume":"240","author":[{"given":"Susanne Barbara Claudia","family":"Mahler","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum des Saarlandes UKS, Homburg\/Saar, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Adams","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum des Saarlandes UKS, Homburg\/Saar, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loay","family":"Daas","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Augenheilkunde, Universit\u00e4tsklinikum des Saarlandes UKS, Homburg\/Saar, Deutschland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achim","family":"Langenbucher","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr 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