{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:39:32Z","timestamp":1784126372462,"version":"3.55.0"},"reference-count":8,"publisher":"Georg Thieme Verlag KG","issue":"06","funder":[{"name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","award":["HD19897,HD21410,HD21414,HD27860,HD27861,HD27869  , , , , ,, , , , , , 1, 2, , H, , ,  H,HD27905,HD27915,HD27917,HD34116,HD34122,HD34136,HD34208,HD34210,HD36801,HD40485,HD40500,HD40512,HD40544,HD40545,HD40560,HD53907,MO1-RR-000080"],"award-info":[{"award-number":["HD19897,HD21410,HD21414,HD27860,HD27861,HD27869  , , , , ,, , , , , , 1, 2, , H, , ,  H,HD27905,HD27915,HD27917,HD34116,HD34122,HD34136,HD34208,HD34210,HD36801,HD40485,HD40500,HD40512,HD40544,HD40545,HD40560,HD53907,MO1-RR-000080"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:p>\n            Objective\u2003To assess whether neonatal morbidities evident by the time of hospital discharge are associated with subsequent cerebral palsy (CP) or death.<\/jats:p><jats:p>\n            Study Design\u2003This is a secondary analysis of data from a multicenter placebo-controlled trial of magnesium sulfate for the prevention of CP. The association between prespecified intermediate neonatal outcomes (n\u2009=\u200911) and demographic and clinical factors (n\u2009=\u200910) evident by the time of discharge among surviving infants (n\u2009=\u20091889) and the primary outcome of death or moderate\/severe CP at age 2 (n\u2009=\u200973) was estimated, and a prediction model was created.<\/jats:p><jats:p>\n            Results\u2003Gestational age in weeks at delivery (odds ratio [OR]: 0.74, 95% confidence interval [CI]: 0.67\u20130.83), grade III or IV intraventricular hemorrhage (IVH) (OR: 5.3, CI: 2.1\u201313.1), periventricular leukomalacia (PVL) (OR: 46.4, CI: 20.6\u2013104.6), and male gender (OR: 2.5, CI: 1.4\u20134.5) were associated with death or moderate\/severe CP by age 2. Outcomes not significantly associated with the primary outcome included respiratory distress syndrome, bronchopulmonary dysplasia, seizure, necrotizing enterocolitis, neonatal hypotension, 5-minute Apgar score, sepsis, and retinopathy of prematurity. Using all patients, the receiver operating characteristic curve for the final prediction model had an area under the curve of 0.84 (CI: 0.78\u20130.89). Using these data, the risk of death or developing CP by age 2 can be calculated for individual surviving infants.<\/jats:p><jats:p>\n            Conclusion\u2003IVH and PVL were the only neonatal complications evident at discharge that contributed to an individual infant's risk of the long-term outcomes of death or CP by age 2. A model that includes these morbidities, gestational age at delivery, and gender is predictive of subsequent neurologic sequelae.<\/jats:p><jats:p>\n            Key Points\n          <\/jats:p>","DOI":"10.1055\/a-1788-6281","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T07:18:57Z","timestamp":1646637537000},"page":"783-789","source":"Crossref","is-referenced-by-count":6,"title":["Prediction of Cerebral Palsy or Death among Preterm Infants Who Survive the Neonatal Period"],"prefix":"10.1055","volume":"41","clinical-trial-number":[{"clinical-trial-number":"nct00014989","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Alan M.","family":"Peaceman","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Northwestern University, Chicago, Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Mele","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, The George Washington University, Washington, District of Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dwight J.","family":"Rouse","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth J.","family":"Leveno","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Mercer","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Case Western Reserve University-MetroHealth Medical Center, Cleveland, Ohio"},{"name":"Department of Obstetrics and Gynecology, University of Tennessee, Memphis, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9455-3973","authenticated-orcid":false,"given":"Michael W.","family":"Varner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Utah, Salt Lake City, Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma M.","family":"Reddy","sequence":"additional","affiliation":[{"name":"Pregnancy and Perinatology Branch, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"Wapner","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, Pennsylvania"},{"name":"Department of Obstetrics and Gynecology, Drexel University, Philadelphia, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoram","family":"Sorokin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Thorp","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Ramin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas Health Science Center at Houston-Children's Memorial Hermann Hospital, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fergal D.","family":"Malone","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Columbia University, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary J.","family":"O'Sullivan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Miami, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald J.","family":"Dudley","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Texas at San Antonio, San Antonio, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve N.","family":"Caritis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Pittsburgh, Pittsburgh, Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Eunice Kennedy Shriver National Institute of Child Health Human Development Maternal-Fetal Medicine Units Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"194","published-online":{"date-parts":[[2022,5,12]]},"reference":[{"issue":"16","key":"ref1","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1056\/NEJMoa073059","article-title":"Intensive care for extreme prematurity\u2013moving beyond gestational age","volume":"358","author":"J E Tyson","year":"2008","journal-title":"N Engl J Med"},{"issue":"02","key":"ref2","doi-asserted-by":"crossref","first-page":"F134","DOI":"10.1136\/adc.2004.052407","article-title":"The EPICure study: associations and antecedents of neurological and developmental disability at 30 months of age following extremely preterm birth","volume":"90","author":"N S Wood","year":"2005","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"issue":"03","key":"ref3","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1542\/peds.2004-2247","article-title":"Neurodevelopmental outcomes of extremely low birth weight infants <32 weeks' gestation between 1993 and 1998","volume":"116","author":"B R Vohr","year":"2005","journal-title":"Pediatrics"},{"issue":"09","key":"ref4","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1056\/NEJMoa0801187","article-title":"A randomized, controlled trial of magnesium sulfate for the prevention of cerebral palsy","volume":"359","author":"D J Rouse","year":"2008","journal-title":"N Engl J Med"},{"issue":"03","key":"ref5","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1067\/mob.2000.104207","article-title":"Fetal exposure to an intra-amniotic inflammation and the development of cerebral palsy at the age of three years","volume":"182","author":"B H Yoon","year":"2000","journal-title":"Am J Obstet Gynecol"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1001\/jama.284.11.1417","article-title":"Chorioamnionitis as a risk factor for cerebral palsy: a meta-analysis","volume":"284","author":"Y W Wu","year":"2000","journal-title":"JAMA"},{"issue":"04","key":"ref7","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0002-9378(97)70271-0","article-title":"Experimentally induced intrauterine infection causes fetal brain white matter lesions in rabbits","volume":"177","author":"B H Yoon","year":"1997","journal-title":"Am J Obstet Gynecol"},{"issue":"04","key":"ref8","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.ajog.2004.03.016","article-title":"Development of a guinea pig model of chorioamnionitis and fetal brain injury","volume":"191","author":"L A Patrick","year":"2004","journal-title":"Am J Obstet Gynecol"}],"container-title":["American Journal of Perinatology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1788-6281.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T10:18:26Z","timestamp":1730801906000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1788-6281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,4]]},"references-count":8,"journal-issue":{"issue":"06","published-online":{"date-parts":[[2024,4,10]]},"published-print":{"date-parts":[[2024,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1788-6281","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0735-1631","1098-8785"],"issn-type":[{"value":"0735-1631","type":"print"},{"value":"1098-8785","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,3,4]]},"published":{"date-parts":[[2022,3,4]]}}}