{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:36:27Z","timestamp":1776904587839,"version":"3.51.2"},"reference-count":65,"publisher":"Georg Thieme Verlag KG","issue":"05","funder":[{"DOI":"10.13039\/501100012155","name":"National Institute for Medical Research Development","doi-asserted-by":"crossref","award":["987766"],"award-info":[{"award-number":["987766"]}],"id":[{"id":"10.13039\/501100012155","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Drug Res (Stuttg)"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acetaminophen (APAP)-induced acute liver injury (ALI) is the principal cause of acute liver failure (ALF) in some countries including the United States and with few available treatments. Isorhamnetin is a bioflavonoid that is found in medicinal plants like Hippophae rhamnoides L. and Ginkgo biloba L. with promising potential to regulate inflammatory responses. In this study, we evaluated the possible effect of isorhamnetin in prevention of APAP-induced ALI and analyzed further the involvement of oxidative stress and inflammation-associated factors. Male C57BL\/6 mice were given isorhamnetin (25 or 100\u2009mg\/kg b.w., p.o.) three times at 48, 24, and 1\u2009h before APAP administration (300\u2009mg\/kg b.w., i.p.). Functional indicators of liver injury were measured as well as analysis of oxidative stress- and inflammation-associated indices and liver histopathology was also conducted. Isorhamnetin at the higher dose of 100\u2009mg\/kg significantly lowered serum levels of ALT, ALP, and AST in addition to reduction of ROS, TBARS, IL-6, TNF\u03b1, NF-kB, NLRP3, caspase 1, and MPO and significantly prevented reduction of GSH, SOD activity, sirtuin 1, and Nrf2. Additionally, isorhamnetin alleviated pathological changes of the liver tissue and suitably reversed NF-kB and Nrf2 immunoreactivity. These findings show protective effect of isorhamnetin against acetaminophen-induced liver injury through reducing oxidative stress, inflammation, and pyroptosis which is attributed to its regulation of NF-kB, Nrf2, NLRP3, and sirtuin 1.<\/jats:p>","DOI":"10.1055\/a-1792-2678","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T23:03:10Z","timestamp":1648767790000},"page":"245-254","source":"Crossref","is-referenced-by-count":35,"title":["Therapeutic Potential of Isorhamnetin following Acetaminophen-Induced Hepatotoxicity through Targeting NLRP3\/NF-\u03baB\/Nrf2"],"prefix":"10.1055","volume":"72","author":[{"given":"Ali-Mohammad","family":"Rousta","sequence":"additional","affiliation":[{"name":"School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed-Mohamad-Sadegh","family":"Mirahmadi","sequence":"additional","affiliation":[{"name":"School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alireza","family":"Shahmohammadi","sequence":"additional","affiliation":[{"name":"School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhila","family":"Mehrabi","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soudabeh","family":"Fallah","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tourandokht","family":"Baluchnejadmojarad","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehrdad","family":"Roghani","sequence":"additional","affiliation":[{"name":"Neurophysiology Research Center, Shahed University, Tehran, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0140-6736(19)31894-X","article-title":"Acute liver failure","volume":"394","author":"R T Stravitz","year":"2019","journal-title":"The Lancet"},{"key":"ref2","first-page":"131","article-title":"Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update","volume":"4","author":"E Yoon","year":"2016","journal-title":"Journal of clinical and translational hepatology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1124\/dmd.31.12.1499","article-title":"Acetaminophen-induced hepatotoxicity","volume":"31","author":"L P 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