{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T08:38:06Z","timestamp":1718872686632},"reference-count":28,"publisher":"Georg Thieme Verlag KG","issue":"02","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Handchir Mikrochir Plast Chir"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>\n          Background The biological mechanism of Dupuytren\u2019s contracture needs to be further studied in order to minimize postoperative recurrence and provide a pathological basis for the development of new therapeutic targets.<\/jats:p><jats:p>\n          Methods HE staining, immunohistochemistry, PCR and western blotting were performed in pathological palmar aponeurosis specimens and normal palmar aponeurosis tissues for comparative study.<\/jats:p><jats:p>\n          Results (1) TNF-\u03b1 expression was up-regulated: TNF-\u03b1 mRNA was more highly expressed in the pathological tissues of DD patients than in the CT group, P &lt; 0.05, and the difference between the two groups was statistically significant; (2) Dkk-1 expression was down-regulated: Dkk-1 mRNA was lower expressed in the pathological tissues of DD patients than in the CT group, P &lt; 0.05, and the difference between the two groups was statistically significant; (3) TGF-\u03b21 expression was up-regulated: TGF-\u03b21 mRNA was higher expressed in the pathological tissues of DD patients than in the CT group, P &lt; 0.05, and the difference between the two groups was statistically significant; (4) Pearson correlation analysis suggested that TNF-\u03b1 expression was positively correlated with TGF-\u03b21 expression, TNF-\u03b1 expression was negatively correlated with DKK-1 expression, and TGF-\u03b21 expression was negatively correlated with DKK-1 expression.<\/jats:p><jats:p>\n          Conclusion TNF-\u03b1, DKK-1 and TGF-\u03b21 may play a role in the pathogenesis of palmar aponeurosis contracture, and there is a relationship between them. The study of the relationship between the three and their related signaling pathways provides a therapeutic target and a basis for the prevention and early treatment of palmar aponeurotic contracture.<\/jats:p>","DOI":"10.1055\/a-1794-5668","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T03:57:51Z","timestamp":1649908671000},"page":"149-154","source":"Crossref","is-referenced-by-count":1,"title":["Study on the Action Mechanism of Dkk-1, TGF-\u03b21 and TNF-\u03b1 Expression Levels in Dupuytren\u2019s Contracture"],"prefix":"10.1055","volume":"54","author":[{"given":"Kecheng","family":"Niu","sequence":"first","affiliation":[{"name":"The third Affiliated Hospital of Inner Mongolia Medicial University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangming","family":"Dai","sequence":"first","affiliation":[{"name":"The third Affiliated Hospital of Inner Mongolia Medicial University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jiang","sequence":"additional","affiliation":[{"name":"The third Affiliated Hospital of Inner Mongolia Medicial University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian","family":"Zhang","sequence":"additional","affiliation":[{"name":"The third Affiliated Hospital of Inner Mongolia Medicial University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peiguang","family":"Zhang","sequence":"additional","affiliation":[{"name":"The third Affiliated Hospital of Inner Mongolia Medicial University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunyan","family":"Tan","sequence":"additional","affiliation":[{"name":"The third Affiliated Hospital of Inner Mongolia Medicial University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Feng","sequence":"additional","affiliation":[{"name":"The third Affiliated Hospital of Inner Mongolia Medicial University"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,4,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1308\/003588406X83104","article-title":"Management of Dupuytren\u2019s disease - clear advice for an elusive condition","volume":"88","author":"A Bayat","year":"2006","journal-title":"Ann R Coll Surg Engl"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"604","DOI":"10.12968\/hmed.2007.68.11.27683","article-title":"Assessment of clinical severity in Dupuytren\u2019s disease","volume":"68","author":"A Bayat","year":"2007","journal-title":"Br J Hosp Med (Lond)"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1302\/0301-620X.85B4.14215","article-title":"Dupuytren\u2019s disease","volume":"85","author":"A J Thurston","year":"2003","journal-title":"J Bone Joint Surg Br"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/SAP.0000000000001918","article-title":"The Molecular Pathogenesis of Dupuytren Disease: Review of the Literature and Suggested New Approaches to Treatment","volume":"83","author":"L R Sayadi","year":"2019","journal-title":"Ann Plast Surg"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"635","DOI":"10.2106\/00004623-195941040-00008","article-title":"Dupuytren\u2019s contracture; a new concept of the pathogenesis correlated with surgical management","volume":"41","author":"J V Luck","year":"1959","journal-title":"J Bone Joint Surg Am"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1073\/pnas.1301100110","article-title":"Unraveling the signaling pathways promoting fibrosis in Dupuytren\u2019s disease reveals TNF as a therapeutic target","volume":"110","author":"L S Verjee","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s12079-016-0331-0","article-title":"Update on the role of molecular factors and fibroblasts in the pathogenesis of Dupuytren\u2019s disease","volume":"10","author":"M Tripoli","year":"2016","journal-title":"J Cell Commun Signal"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/ncomms1734","article-title":"Activation of canonical Wnt signalling is required for TGF-\u03b2-mediated fibrosis","volume":"3","author":"A Akhmetshina","year":"2012","journal-title":"Nat Commun"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cell.2012.05.012","article-title":"Wnt\/\u03b2-catenin signaling and disease","volume":"149","author":"H Clevers","year":"2012","journal-title":"Cell"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/nrg1427","article-title":"WNT and beta-catenin signalling: diseases and therapies","volume":"5","author":"R T Moon","year":"2004","journal-title":"Nat Rev Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1073\/pnas.1301100110","article-title":"Unraveling the signaling pathways promoting fibrosis in Dupuytren\u2019s disease reveals TNF as a therapeutic target","volume":"110","author":"L S Verjee","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1055\/s-0037-1608749","article-title":"Efficacy of collagenase Clostridium histolyticum for Dupuytren disease: a systematic review","volume":"45","author":"R Sanjuan-Cerver\u00f3","year":"2017","journal-title":"Rev Iberoam Cir Mano"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/nrneph.2014.246","article-title":"Diverse origins of the myofibroblast \u2013 implications for kidney fibrosis","volume":"11","author":"L L Falke","year":"2015","journal-title":"Nat Rev Nephrol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1016\/j.biochi.2013.09.003","article-title":"Wnt signaling in liver fibrosis: progress, challenges and potential directions","volume":"95","author":"C G Miao","year":"2013","journal-title":"Biochimie"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"e84916","DOI":"10.1172\/jci.insight.84916","article-title":"Tubular Dickkopf-3 promotes the development of renal atrophy and fibrosis","volume":"1","author":"G Federico","year":"2016","journal-title":"JCI Insight"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.3892\/ijmm.2014.1672","article-title":"Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells, contributing to pulmonary fibrosis","volume":"33","author":"Z R Sun","year":"2014","journal-title":"Int J Mol Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.4103\/0366-6999.181974","article-title":"Dickkopf-1 has an Inhibitory Effect on Mesenchymal Stem Cells to Fibroblast Differentiation","volume":"129","author":"Y Li","year":"2016","journal-title":"Chin Med J"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1002\/jcp.26112","article-title":"TNF-\u03b1-induced NF-\u03baB activation promotes myofibroblast differentiation of LR-MSCs and exacerbates bleomycin-induced pulmonary fibrosis","volume":"233","author":"J W Hou","year":"2018","journal-title":"J Cell Physiol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jss.2016.04.034","article-title":"TNF-\u03b1 stimulates colonic myofibroblast migration via COX-2 and Hsp27","volume":"204","author":"S Saini","year":"2016","journal-title":"J Surg Res"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5390","DOI":"10.1111\/jcmm.14420","article-title":"Bortezomib attenuates renal interstitial fibrosis in kidney transplantation via regulating the EMT induced by TNF-\u03b1-Smurf1-Akt-mTOR-P70S6K pathway","volume":"23","author":"J J Zhou","year":"2019","journal-title":"J Cell Mol Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1007\/s43032-020-00139-0","article-title":"The Effects of Anti-TGF-\u03b21 on Epithelial-Mesenchymal Transition in the Pathogenesis of Adenomyosis","volume":"27","author":"N Kay","year":"2020","journal-title":"Reprod Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.matbio.2019.12.001","article-title":"Loss of LRP1 promotes acquisition of contractile-myofibroblast phenotype and release of active TGF-\u03b21 from ECM stores","volume":"88","author":"J Schnieder","year":"2020","journal-title":"Matrix Biol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s00441-019-03110-x","article-title":"Wnt4 negatively regulates the TGF-\u03b21-induced human dermal fibroblast-to-myofibroblast transition via targeting Smad3 and ERK","volume":"379","author":"J Q Liu","year":"2020","journal-title":"Cell Tissue Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"90579","DOI":"10.18632\/oncotarget.21234","article-title":"Interactions between TGF-\u03b21, canonical WNT\/\u03b2-catenin pathway and PPAR \u03b3 in radiation-induced fibrosis","volume":"8","author":"A Vall\u00e9e","year":"2017","journal-title":"Oncotarget"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.ejphar.2016.06.006","article-title":"Pharmacological activation of cannabinoid 2 receptor attenuates inflammation, fibrogenesis, and promotes re-epithelialization during skin wound healing","volume":"786","author":"L L Wang","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.intimp.2018.12.050","article-title":"Inhibition of tumor necrosis factor-alpha (TNF-alpha) in patients with early rheumatoid arthritis results in acute changes of bone modulators","volume":"67","author":"A Fassio","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s10067-018-4284-y","article-title":"Correlation between magnetic resonance imaging (MRI) findings and the new bone formation factor Dkk-1 in patients with spondyloarthritis","volume":"38","author":"Z Zhao","year":"2019","journal-title":"Clin Rheumatol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"41612","DOI":"10.1038\/srep41612","article-title":"LPS-induced inflammatory response is suppressed by Wnt inhibitors, Dickkopf-1 and LGK974","volume":"7","author":"J Jang","year":"2017","journal-title":"Sci Rep"}],"container-title":["Handchirurgie \u00b7 Mikrochirurgie \u00b7 Plastische Chirurgie"],"original-title":[],"language":"de","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1794-5668.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T23:02:49Z","timestamp":1654729369000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1794-5668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":28,"journal-issue":{"issue":"02","published-online":{"date-parts":[[2022,4,13]]},"published-print":{"date-parts":[[2022,4]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1794-5668","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0722-1819","1439-3980"],"issn-type":[{"value":"0722-1819","type":"print"},{"value":"1439-3980","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4]]}}}