{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T23:22:10Z","timestamp":1791501730276,"version":"4.3.4"},"reference-count":12,"publisher":"Georg Thieme Verlag KG","issue":"03","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Zentralbl Chir"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Neuroendokrine Neoplasien (NEN) der Appendix stellen mit 80% die h\u00e4ufigste Neoplasie dieser Lokalisation dar. In den meisten F\u00e4llen werden diese Tumoren als Zufallsbefund nach stattgehabter\n          Appendektomie bei V.\u00a0a. Appendizitis diagnostiziert. Hierbei handelt es sich meist um hoch differenzierte neuroendokrine Tumoren. Aufgrund ihrer h\u00e4ufigen Lage im Bereich der Appendixspitze\n          sind die NEN der Appendix meist nicht urs\u00e4chlich f\u00fcr die Appendizitis-typischen Beschwerden.<\/jats:p><jats:p>Die meisten Patienten (80\u201390%) sind durch die bereits durchgef\u00fchrte Appendektomie ausreichend onkologisch therapiert. Sollten sich jedoch Risikofaktoren wie eine Tumorgr\u00f6\u00dfe &gt;\u00a02\u00a0cm,\n          basisnahe Lage, Angioinvasion, Perforation oder Infiltration von Nachbarorganen, Proliferationsindex von &gt;\u00a02% oder eine Infiltration des Mesoappendix von mehr als 3\u00a0mm im endg\u00fcltigen\n          histopathologischen Befund ergeben, so wird eine Nachresektion als onkologische Hemikolektomie rechts empfohlen.<\/jats:p><jats:p>Aufgrund des meist fr\u00fchen Tumorstadiums bei Diagnosestellung ohne nachgewiesene Lymphknotenmetastasierung weisen Patienten mit einer NEN der Appendix exzellente 5-Jahres-\u00dcberlebensraten\n          \u00fcber alle Tumorstadien hinweg von 70\u201385% auf.<\/jats:p>","DOI":"10.1055\/a-1798-0646","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T22:40:32Z","timestamp":1655332832000},"page":"244-248","source":"Crossref","is-referenced-by-count":2,"title":["Zufallsbefund NEN Appendix"],"prefix":"10.1055","volume":"147","author":[{"given":"Michael","family":"Thomas","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Viszeral-, Allgemeine-, Tumor- und Transplantationschirurgie, Universit\u00e4tsklinikum K\u00f6ln, Koln, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Wahba","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Viszeral-, Allgemeine-, Tumor- und Transplantationschirurgie, Universit\u00e4tsklinikum K\u00f6ln, Koln, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costanza","family":"Chiapponi","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Viszeral-, Allgemeine-, Tumor- und Transplantationschirurgie, Universit\u00e4tsklinikum K\u00f6ln, Koln, Deutschland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk L.","family":"Stippel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Viszeral-, Allgemeine-, 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