{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:57:23Z","timestamp":1762642643895,"version":"3.37.3"},"reference-count":29,"publisher":"Georg Thieme Verlag KG","issue":"09","funder":[{"name":"Christopher Hess Research Fund"},{"name":"Prematurity Research Fund"},{"name":"Charles B. and Ann L. Johnson Research Fund"},{"name":"Providence Foundation Research Fund"},{"name":"March of Dimes Prematurity Research Center at Stanford University"},{"DOI":"10.13039\/100015521","name":"Stanford Maternal and Child Health Research Institute","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015521","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Roberts Foundation Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Perinatol"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Understanding the role of stress in pregnancy and its consequences is important, particularly given documented associations between maternal stress and preterm birth and other pathological outcomes. Physical and psychological stressors can elicit the same biological responses, known as biological strain. Chronic stressors, like poverty and racism (race-based discriminatory treatment), may create a legacy or trajectory of biological strain that no amount of coping can relieve in the absence of larger-scale socio-behavioral or societal changes. An integrative approach that takes into consideration simultaneously social and biological determinants of stress may provide the best insights into the risk of preterm birth. The most successful computational approaches and the most predictive machine-learning models are likely to be those that combine information about the stressors and the biological strain (for example, as measured by different omics) experienced during pregnancy.<\/jats:p>","DOI":"10.1055\/a-1798-1602","type":"journal-article","created":{"date-parts":[[2022,3,16]],"date-time":"2022-03-16T00:11:12Z","timestamp":1647389472000},"page":"1282-1284","source":"Crossref","is-referenced-by-count":1,"title":["Stress and Its Consequences\u2014Biological Strain"],"prefix":"10.1055","volume":"41","author":[{"given":"David K.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian H.","family":"Gotlib","sequence":"additional","affiliation":[{"name":"Department of Psychology, Stanford 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