{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T09:40:18Z","timestamp":1652348418746},"reference-count":14,"publisher":"Georg Thieme Verlag KG","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dtsch Med Wochenschr"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>\n          Anamnese und klinischer Befund\u2002Ein 60-j\u00e4hriger Patient wurde bei einer seit 6 Monaten zunehmenden schmerzlosen Umfangsverminderung der rechten Wade mit leichter Gangst\u00f6rung eingewiesen. Neurologisch fand sich eine atrophische Monoparese des rechten Unterschenkels mit erhaltenen Muskeleigenreflexen ohne sensible St\u00f6rungen.<\/jats:p><jats:p>\n          Untersuchungen\u2002Elektrophysiologisch bzw. neuroradiologisch zeigte nur der rechte M. triceps surae Zeichen einer kombinierten frischen und chronischen Sch\u00e4digung bzw. eine ausgepr\u00e4gte Atrophie mit diffusem Muskel\u00f6dem. Bei erh\u00f6hten Leberwerten war bei bisher nicht bekannter positiver Hepatitis-C-Serologie und hoher Hepatitis-C-Viruslast im\u00a0Serum sogar im Liquor eine Pleozytose mit sehr niedriger Viruslast nachweisbar.<\/jats:p><jats:p>\n          Diagnose\u2002Es wurde die Diagnose einer Hepatitis-C-assoziierten Mononeuropathie des rechten N. ischiadicus mit Schwerpunktbeteiligung des rechten N. tibialis gestellt.<\/jats:p><jats:p>\n          Therapie und Verlauf\u2002Nach Therapie mit Sofosbuvir und Velpatasvir trat im Verlauf keine weitere Progredienz der Monoparese mehr auf.<\/jats:p><jats:p>\n          Folgerung\u2002Eine chronische Hepatitis C kann in seltenen F\u00e4llen mit einer schmerzlosen progredienten Monoparese assoziiert sein. Der Stellenwert von Liquor bez\u00fcglich der Pathogenese erfordert weitere Studien.<\/jats:p>","DOI":"10.1055\/a-1799-1850","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T22:30:37Z","timestamp":1652308237000},"page":"613-616","source":"Crossref","is-referenced-by-count":0,"title":["Klinische Erstmanifestation einer chronischen Hepatitis C bei\u00a0schmerzloser progredienter atrophischer Monoparese des\u00a0rechten Beines"],"prefix":"10.1055","volume":"147","author":[{"given":"Thorleif","family":"Etgen","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Neurologie, Klinikum Traunstein"},{"name":"Klinik und Poliklinik f\u00fcr Psychiatrie und Psychotherapie, Technische Universit\u00e4t M\u00fcnchen"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Winklmaier","sequence":"additional","affiliation":[{"name":"Internistisch-haus\u00e4rztliche Praxisgemeinschaft, Waldkraiburg"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1001\/jamaneurol.2015.2347","article-title":"The Importance of Rare Subtypes in Diagnosis and Treatment of Peripheral Neuropathy: A Review","volume":"72","author":"B C Callaghan","year":"2015","journal-title":"JAMA Neurol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"291","DOI":"10.3389\/fneur.2019.00291","article-title":"Biomarkers in Motor Neuron Disease: A State of the Art Review","volume":"10","author":"N S Verber","year":"2019","journal-title":"Front Neurol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1159\/000008183","article-title":"Benign monomelic amyotrophy of the lower limb--case report and brief review of the literature","volume":"43","author":"A Munchau","year":"2000","journal-title":"Eur Neurol"},{"key":"ref4","first-page":"725","article-title":"Diabetic polyradiculopathy: clinical and electromyographic findings in 105 patients","volume":"56","author":"J A Bastron","year":"1981","journal-title":"Mayo Clin Proc"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S1474-4422(13)70236-9","article-title":"Vasculitic neuropathies","volume":"13","author":"K G Gwathmey","year":"2014","journal-title":"Lancet Neurol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1212\/01.wnl.0000082715.48844.3e","article-title":"Nonsystemic vasculitic neuropathy: insights from a clinical cohort","volume":"61","author":"M P Collins","year":"2003","journal-title":"Neurology"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-020-04998-y","article-title":"Update on therapy of chronic immune-mediated neuropathies","author":"C Briani","year":"2021","journal-title":"Neurol Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"2204","DOI":"10.1002\/1529-0131(199910)42:10<2204::AID-ANR24>3.0.CO;2-D","article-title":"Extrahepatic manifestations of chronic hepatitis C. 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