{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:45Z","timestamp":1740126825618,"version":"3.37.3"},"reference-count":50,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Z Gastroenterol"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Das menschliche Mikrobiom und im speziellen die gastrointestinale Mikrobiota sind mit Gesundheit und Krankheit assoziiert. Eine St\u00f6rung ihrer Zusammensetzung oder Funktion (Dysbiose) spielen eine Rolle bei der Entstehung von kindergastroenterologischen Krankheitsbildern. Der f\u00e4kale Mikrobiota-Transfer (FMT) ist eine spezielle Intervention, bei der intestinale Mikrobiota eines gesunden Spenders transferiert werden.<\/jats:p><jats:p>In diesem Review beschreiben wir die aktuelle Studienlage bez\u00fcglich FMT bei p\u00e4diatrischen Patient*innen. F\u00fcr rezidivierende C. difficile-Infektionen bestehen eine gute Datenlage und Empfehlungen der entsprechenden Fachgesellschaften. Bei der Behandlung von chronisch-entz\u00fcndlichen Darmerkrankungen (CED) mittels FMT liegen erste Daten vor, die auf eine Reduktion der Krankheitsschwere hindeuten.<\/jats:p><jats:p>Nebenwirkungen traten in Studien h\u00e4ufig auf, zeigten sich aber meist milde und transient. Zu in der P\u00e4diatrie besonders bedeutsamen langfristigen Nebenwirkungen eines FMT existieren kaum Daten.<\/jats:p><jats:p>Bei der praktischen Durchf\u00fchrung besteht gro\u00dfe Unklarheit, welche Modalit\u00e4ten und Applikationsrouten angewendet werden sollten. Rechtlich gilt Spenderstuhl im deutschsprachigen Raum als Arzneimittel, f\u00fcr das keine Zulassung vorliegt.<\/jats:p><jats:p>Insgesamt sind die Erkenntnisse zu den physiologischen Zusammenh\u00e4ngen, Wirkungen und Nebenwirkungen noch unzureichend und rechtliche Rahmenbedingungen erschweren die Durchf\u00fchrung. Weitere klinische Studien auf dem Gebiet sind zwingend notwendig.<\/jats:p>","DOI":"10.1055\/a-1801-0284","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T22:38:17Z","timestamp":1652135897000},"page":"963-969","source":"Crossref","is-referenced-by-count":0,"title":["F\u00e4kaler Mikrobiota Transfer (FMT) bei Kindern und Jugendlichen\n \u2013 Review und Stellungnahme der GPGE AG Mikrobiom"],"prefix":"10.1055","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6724-0015","authenticated-orcid":false,"given":"Alexander","family":"Joachim","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Kinder- und Jugendmedizin, Uniklinik K\u00f6ln, K\u00f6ln, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Schwerd","sequence":"additional","affiliation":[{"name":"Kinderklinik und Kinderpoliklinik im Dr. von Haunerschen Kinderspital, Klinikum der Universtit\u00e4t M\u00fcnchen, LMU M\u00fcnchen, 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