{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:43Z","timestamp":1740126823090,"version":"3.37.3"},"reference-count":112,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fortschr Neurol Psychiatr"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Zusammenfassung<\/jats:title><jats:p>Die gr\u00f6\u00dften Speicheldr\u00fcsen sind die paarigen Gl. parotis\n                    und Gl. submandibularis. Der erwachsene Mensch produziert\n                    1\u20131,5\u2009l Speichel am Tag, die er regelm\u00e4\u00dfig\n                    abschluckt. Die h\u00e4u\ufb01gste Ursache eines vermehrten\n                    Speichel\ufb02usses mit einer Ansammlung von Speichel im Mund und\n                    Aus\ufb02uss (Sialorrhoe) ist eine St\u00f6rung der Schluckfunktion.\n                    Seltener kann auch eine vermehrte Speichelsekretion, z.\u2009B.\n                    medikament\u00f6s bedingt, die Ursache sein. Eine Sialorrhoe\n                    beeintr\u00e4chtigt die Lebensqualit\u00e4t erheblich und ist oft auch\n                    sozial stigmatisierend. Die Therapie umfasst konservative Ma\u00dfnahmen wie\n                    die funktionelle Dysphagietherapie, orale oder transdermale Applikation von\n                    Anticholinergika sowie, in ausgew\u00e4hlten F\u00e4llen, invasive\n                    Therapien wie Bestrahlungen und Operationen. Seit 20 Jahren wird auch die lokale\n                    Injektion von Botulinumtoxin in die Speicheldr\u00fcsen erfolgreich\n                    therapeutisch eingesetzt. Durch die Zulassung von IncobotulinumtoxinA\n                    f\u00fcr die Behandlung von Kindern und Erwachsenen darf diese\n                    Ma\u00dfnahme als Therapie der Wahl bei chronischer Sialorrhoe angesehen\n                    werden. Die Ergebnisse der Zulassungsstudien zeigen bei Kindern wie auch\n                    Erwachsenen eine hohe Effektivit\u00e4t und gute Vertr\u00e4glichkeit der\n                    Injektionsbehandlung.<\/jats:p>","DOI":"10.1055\/a-1802-3867","type":"journal-article","created":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T22:52:26Z","timestamp":1650667946000},"page":"222-232","source":"Crossref","is-referenced-by-count":2,"title":["Therapie der Sialorrhoe mit Botulinumtoxin \u2013 ein\n                    Update"],"prefix":"10.1055","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8574-3297","authenticated-orcid":false,"given":"Wolfgang H.","family":"Jost","sequence":"additional","affiliation":[{"name":"Parkinson-Klinik Ortenau, Wolfach, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"B\u00e4umer","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Systemische Motorikforschung, CBBM, Sektion\n                    Zentrum f\u00fcr Seltene Erkrankungen, UKSH, Universit\u00e4t zu\n                    L\u00fcbeck, L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Berweck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Laskawi","sequence":"additional","affiliation":[{"name":"Georg-August-Universitat G\u00f6ttingen HNO-Klinik,\n                    G\u00f6ttingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Spittau","sequence":"additional","affiliation":[{"name":"Anatomie und Zellbiologie, Medizinische Fakult\u00e4t OWL,\n                    Universit\u00e4t Bielefeld, Bielefeld, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armin","family":"Steffen","sequence":"additional","affiliation":[{"name":"Universit\u00e4tsklinikum Schleswig-Holstein Campus L\u00fcbeck\n                    HNO Klinik, L\u00fcbeck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Winterholler","sequence":"additional","affiliation":[{"name":"Krankenhaus Rummelsberg gGmbH, Schwarzenbruck, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,4,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.otc.2015.10.002","article-title":"Facial nerve and parotid gland anatomy. 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