{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:33:31Z","timestamp":1740126811850,"version":"3.37.3"},"reference-count":11,"publisher":"Georg Thieme Verlag KG","issue":"05","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study explores the core genes involved in the pathogenesis of\n                    ACTH-independent macronodular adrenal hyperplasia (AIMAH), so as to provide\n                    robust biomarkers for the clinical diagnosis and treatment of this disease. Gene\n                    Expression Omnibus (GEO) database was used to obtain GSE25031 microarray\n                    dataset. R package \u201climma\u201d was applied to identify\n                    differentially expressed genes (DEGs) between AIMAH and normal samples. The\n                    Database for Annotation, Visualization and Integrated Discovery (DAVID) was\n                    employed to perform Gene Ontology (GO) annotation for the DEGs, and Kyoto\n                    Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis was\n                    conducted. A protein-protein interaction network (PPI) was constructed using the\n                    STRING online website and visualized using the Cytoscape software. The key\n                    modules and hub genes were then identified. Finally, Gene Set Enrichment\n                    Analysis (GSEA) enrichment analysis was carried out to find the signaling\n                    pathways of significant clinical value in AIMAH. A total of 295 DEGs between\n                    AIMAH and healthy samples were screened out, including 164 upregulated genes and\n                    131 downregulated genes. Combining enrichment analysis and PPI network\n                    construction, there were 5 signifiant pathways and 10 hub genes, among which 3\n                    genes (FOS, FOSB, and DUSP1) were identified as potential core genes of clinical\n                    significance in AIMAH. In conclusion, the 3 core genes, FOS, FOSB, and DUSP1,\n                    identified here might be potential biomarkers for AIMAH, and the current study\n                    is of guiding significance for clinical diagnosis and treatment of this\n                    disease.<\/jats:p>","DOI":"10.1055\/a-1804-6047","type":"journal-article","created":{"date-parts":[[2022,5,9]],"date-time":"2022-05-09T22:33:13Z","timestamp":1652135593000},"page":"288-293","source":"Crossref","is-referenced-by-count":0,"title":["Exploration of Core Genes in ACTH-Independent Macronodular Adrenal\n                    Hyperplasia"],"prefix":"10.1055","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3005-4398","authenticated-orcid":false,"given":"Junwu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Affiliated Hospital of Chongqing\n                    Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunhui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Presbyatric, The Second Affiliated Hospital of Chongqing\n                    Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinke","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Affiliated Hospital of Chongqing\n                    Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronggui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Urology, The Second Affiliated Hospital of Chongqing\n                    Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,9]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2930","DOI":"10.1210\/jc.2009-0516","article-title":"Clinical and genetic heterogeneity, overlap with other tumor syndromes, and\n                    atypical glucocorticoid hormone secretion in adrenocorticotropin-independent\n                    macronodular adrenal hyperplasia compared with other adrenocortical tumors","volume":"94","author":"H P Hsiao","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"E728","DOI":"10.1210\/jc.2010-2420","article-title":"Integrated genomic analysis of nodular tissue in macronodular adrenocortical\n                    hyperplasia: progression of tumorigenesis in a disorder associated with multiple\n                    benign lesions","volume":"96","author":"M Q Almeida","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1507\/endocrj.50.739","article-title":"A case of ACTH-producing pheochromocytoma associated with pregnancy","volume":"50","author":"H Oh","year":"2003","journal-title":"Endocr J"},{"key":"ref4","first-page":"84","article-title":"Adrenal cortex-medulla mixed lesions","volume":"6","author":"W L Hu","year":"2012","journal-title":"Chin J Laparoscop Urol (Electronic Edition)"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1530\/eje.1.02324","article-title":"Familial adrenocorticotropin-independent macronodular adrenal hyperplasia with\n                    aberrant serotonin and vasopressin adrenal receptors","volume":"156","author":"D Vezzosi","year":"2007","journal-title":"Eur J Endocrinol"},{"key":"ref6","first-page":"203","article-title":"Adrenocortical nodules in post-mortem series. 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