{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:19:50Z","timestamp":1770884390163,"version":"3.50.1"},"reference-count":51,"publisher":"Georg Thieme Verlag KG","issue":"06","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacopsychiatry"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Introduction Long-acting injectable (LAI) antipsychotics are prescribed to\n                    people with severe psychiatric disorders who show poor adherence to oral\n                    medication. The present paper examined factors potentially associated with\n                    medication adherence to LAI treatment.<\/jats:p>\n                  <jats:p>Methods The STAR (Servizi Territoriali Associati per la Ricerca) Network\n                    Depot Study was a multicenter, observational, prospective study that enrolled\n                    461 subjects initiating a LAI from 32 Italian centers. After 6 and 12 months of\n                    treatment, we evaluated differences between participants with high (\u22655\n                    points) and low (&lt;5 points) medication adherence using Kemp\u2019s\n                    7-point scale in sociodemographic, clinical, psychopathological, and\n                    drug-related variables. Factors that differed significantly between the two\n                    groups were entered for multivariate logistic regression.<\/jats:p>\n                  <jats:p>Results Six months after enrollment, participants with high medication\n                    adherence were younger, living with other people, had lower Brief Psychiatric\n                    Rating Scale (BPRS) total scores, lower adverse events, and a more positive\n                    attitude toward medication than participants with low adherence. Multivariate\n                    regression confirmed lower BPRS resistance and activation scores, absence of\n                    adverse events, and positive attitude toward medication as factors significantly\n                    associated with good adherence. After 12 months, all BPRS subscales were\n                    significantly lower in the high adherence group, which also showed a more\n                    positive attitude toward medication. BPRS resistance and attitude toward\n                    medication were confirmed as factors associated with medication adherence.<\/jats:p>\n                  <jats:p>Discussion Our findings suggest that adherence to LAI is principally\n                    related to attitude toward medication and traits of\n                    suspiciousness\/hostility. Quality of patient-clinician relationship and\n                    tailored psychoeducational strategies may positively affect adherence in people\n                    undergoing psychopharmacological treatment, including LAI.<\/jats:p>","DOI":"10.1055\/a-1804-6211","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T19:35:37Z","timestamp":1650915337000},"page":"281-289","source":"Crossref","is-referenced-by-count":7,"title":["Factors Associated with Medication Adherence to Long-Acting\n                    Injectable Antipsychotics: Results from the STAR Network Depot\n                    Study"],"prefix":"10.1055","volume":"55","author":[{"given":"Andrea","family":"Aguglia","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics,\n                    Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa,\n                    Italy"},{"name":"IRCCS Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Fusar-Poli","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Psychiatry Unit,\n                    University of Catania, Via Santa Sofia, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antimo","family":"Natale","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Psychiatry Unit,\n                    University of Catania, Via Santa Sofia, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Amerio","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics,\n                    Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa,\n                    Italy"},{"name":"IRCCS Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Espa","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics,\n                    Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa,\n                    Italy"},{"name":"IRCCS Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Villa","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics,\n                    Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa,\n                    Italy"},{"name":"IRCCS Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Martinotti","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Imaging and Clinical Sciences, \u201cG.\n                    D\u2019Annunzio\u201d University of Chieti, Chieti, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Carr\u00e0","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, via\n                    Cadore, Monza, Italy"},{"name":"Division of Psychiatry, University College London, Tottenham Court Rd,\n                    Bloomsbury, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bartoli","sequence":"additional","affiliation":[{"name":"Department of Medicine and Surgery, University of Milano-Bicocca, via\n                    Cadore, Monza, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"D\u2019Agostino","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of Milan, Ospedale San Paolo,\n                    Blocco A, Via Antonio di Rudin\u00ec, Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Serafini","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics,\n                    Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa,\n                    Italy"},{"name":"IRCCS Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Amore","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics,\n                    Maternal and Child Health (DINOGMI), Section of Psychiatry, University of Genoa,\n                    Italy"},{"name":"IRCCS Ospedale Policlinico San Martino, Genoa, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenio","family":"Aguglia","sequence":"additional","affiliation":[{"name":"Department of Clinical and Experimental Medicine, Psychiatry Unit,\n                    University of Catania, Via Santa Sofia, Catania, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Ostuzzi","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Research and Training in Mental Health and\n                    Service Evaluation; Department of Neuroscience, Biomedicine and Movement\n                    Sciences, Section of Psychiatry, University of Verona, Verona,\n                    Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Corrado","family":"Barbui","sequence":"additional","affiliation":[{"name":"WHO Collaborating Centre for Research and Training in Mental Health and\n                    Service Evaluation; Department of Neuroscience, Biomedicine and Movement\n                    Sciences, Section of Psychiatry, University of Verona, Verona,\n                    Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"ref1","volume-title":"Compliance in health care","author":"R B Haynes","year":"1979"},{"key":"ref2","volume-title":"Adherence to treatment in medical condition","author":"L B Myers","year":"1998"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"30","DOI":"10.5498\/wjp.v4.i2.30","article-title":"What\u2019s in a name? 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