{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:07:44Z","timestamp":1758816464999,"version":"3.37.3"},"reference-count":27,"publisher":"Georg Thieme Verlag KG","issue":"08","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Metab Res"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Subacute thyroiditis (SAT) is an inflammatory disease of the thyroid that\n                    develops following viral upper respiratory tract infections. SARS-CoV-2 virus,\n                    the cause of COVID-19, binds to the Angiotensin-Converting Enzyme-2 (ACE2)\n                    molecule expressed on the target cell surface. Thyroid gland shows high levels\n                    of ACE2 expression. The cases of SARS-CoV-2-related subacute thyroiditis and\n                    Graves\u2019 disease have been reported. It has recently been noted that\n                    vaccines for SARS-CoV-2 also induce autoimmune and inflammatory reactions. We\n                    present six (4 male, 2 female) cases of SAT that developed after mRNA and\n                    inactivated SARS-CoV-2 vaccines. And we have reviewed the literature. SAT was\n                    seen in 5 patients after mRNA vaccine, in one after inactivated vaccine. Their\n                    clinic and laboratory findings suggested to SAT. They were treated with\n                    nonsteroid anti-inflamatory drugs and\/or methylprednisolone.They\n                    recovered within few weeks. Out patients did not have permanent hypothyroidism\n                    after SAT. The history of SARS-CoV-2 vaccination should be questioned in\n                    patients with subacute thyroiditis in pandemic days.<\/jats:p>","DOI":"10.1055\/a-1804-9561","type":"journal-article","created":{"date-parts":[[2022,3,23]],"date-time":"2022-03-23T00:09:00Z","timestamp":1647994140000},"page":"556-561","source":"Crossref","is-referenced-by-count":4,"title":["Subacute Thyroiditis Following SARS-CoV-2 Vaccines: Six Cases Report\n                    and Review of the Literature"],"prefix":"10.1055","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0356-7603","authenticated-orcid":false,"given":"Neslihan","family":"Kurtulmus","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Acibadem Maslak Hospital,\n                    Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kubra","family":"Kayikci","sequence":"additional","affiliation":[{"name":"Medical School, Bezmialem Vakif University, Istanbul,\n                    Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"194","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.mcna.2012.01.003","article-title":"Subacute, silent, and postpartum thyroiditis","volume":"96","author":"M H Samuels","year":"2012","journal-title":"Med Clin North Am"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1743-422X-6-5","article-title":"Viruses and thyroiditis: an update","volume":"6","author":"R Desailloud","year":"2009","journal-title":"Virol J"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.cell.2020.02.052","article-title":"SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically\n                    proven protease inhibitor","volume":"181","author":"M 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(COVID-19)","volume":"13","author":"S O Oyibo","year":"2021","journal-title":"Cureus"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1080\/21645515.2015.1117716","article-title":"Subacute thyroiditis following seasonal influenza vaccination","volume":"12","author":"F A Altay","year":"2016","journal-title":"Hum Vaccin Immunother"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.jaut.2010.07.003","article-title":"\u2018ASIA\u2019 \u2013 autoimmune\/inflammatory syndrome\n                    induced by adjuvants","volume":"36","author":"Y Shoenfeld","year":"2011","journal-title":"J Autoimmun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"589833","DOI":"10.3389\/fimmu.2020.589833","article-title":"Adjuvants for coronavirus vaccines","volume":"11","author":"Z Liang","year":"2020","journal-title":"Front 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Vojdani","year":"2020","journal-title":"Clinical Immunol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1038\/cmi.2017.151","article-title":"Vaccine-induced autoimmunity: the role of molecular mimicry and immune\n                    crossreaction","volume":"6","author":"Y Segal","year":"2018","journal-title":"Cell Mol Immunol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"108665","DOI":"10.1016\/j.clim.2021.108665","article-title":"Do COVID-19 RNA-based vaccines put at risk of immune-mediated diseases? In reply\n                    to \u201cpotential antigenic cross-reactivity between SARS-CoV- 2 and human\n                    tissue with a possible link to an increase in autoimmune diseases\u201d","volume":"224","author":"R Talotta","year":"2021","journal-title":"Clin Immunol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e246425","DOI":"10.1136\/bcr-2021-246425","article-title":"COVID-19 vaccine-associated subacute thyroiditis: an unusual suspect for de\n                    Quervain\u2019s thyroiditis","volume":"14","author":"M S Jeeyavudeen","year":"2021","journal-title":"BMJ Case Rep"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"106700","DOI":"10.1016\/j.cct.2022.106700","article-title":"COVID-19 vaccines: Considering sex differences in efficacy and safety","volume":"115","author":"A Jensen","year":"2022","journal-title":"Contemp Clin Trials"},{"key":"ref29","first-page":"1","article-title":"Subacute thyroiditis during the COVID-19 pandemic: a prospective study","volume":"13","author":"A B Bahcecioglu","year":"2022","journal-title":"J Endocrinol Invest"}],"container-title":["Hormone and Metabolic Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.thieme-connect.de\/products\/ejournals\/pdf\/10.1055\/a-1804-9561.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T23:41:19Z","timestamp":1661384479000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.thieme-connect.de\/DOI\/DOI?10.1055\/a-1804-9561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,22]]},"references-count":27,"journal-issue":{"issue":"08","published-online":{"date-parts":[[2022,8,9]]},"published-print":{"date-parts":[[2022,8]]}},"URL":"https:\/\/doi.org\/10.1055\/a-1804-9561","archive":["Portico","CLOCKSS"],"relation":{},"ISSN":["0018-5043","1439-4286"],"issn-type":[{"type":"print","value":"0018-5043"},{"type":"electronic","value":"1439-4286"}],"subject":[],"published-other":{"date-parts":[[2022,3,22]]},"published":{"date-parts":[[2022,3,22]]}}}